In the original publication [1], there was a mistake in Figure 8F as published. The Western blotting bands for ASC and Caspase-1 exhibit unintended duplication. The corrected Figure 8 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Figure 8.
Knockdown of S100A4 inhibited the NF-κB signaling pathway and reduced the expression of NLRP3 inflammasome and pyroptosis-related proteins. (A,B) si-S100A4 downregulated the expression of p-NF-κB. The protein expression levels of p-NF-κB and NF-κB were analyzed using Western blot in the THP-1 macrophages pre-treated with si-S100A4 for 24 h and infected with BCG for 24 h subsequently. (C–E) The protein expression levels of p-NF-κB and NF-κB in the THP-1 macrophages, which were pre-treated with Triptolide (TPL) 5 nM for 2 h and infected with BCG for 24 h, were quantitatively analyzed using Western blot. (F,G) Inhibition of NF-κB decreased the expression of inflammatory-related proteins (NLRP3, Caspase-1 p48, ASC) and a pyroptosis-related protein (GSDMD-N). Data are from mean ± SD of three independent experiments, ns p > 0.05, * p < 0.05, *** p < 0.001.
Reference
- Li, M.; Liu, Y.; Nie, X.; Ma, B.; Ma, Y.; Hou, Y.; Yang, Y.; Xu, J.; Wang, Y. S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling Pathway. Int. J. Mol. Sci. 2023, 24, 12709. [Google Scholar] [CrossRef] [PubMed]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).