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Review

Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications

by
Hyein Song
,
Jiyong Lee
,
Yeeun Lee
,
Seungju Kim
and
Shinwoo Kang
*
Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, 31, Soonchunhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Chungcheongnam-do, Republic of Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(7), 3272; https://doi.org/10.3390/ijms26073272
Submission received: 13 February 2025 / Revised: 29 March 2025 / Accepted: 31 March 2025 / Published: 1 April 2025
(This article belongs to the Special Issue Latest Review Papers in Molecular Neurobiology 2025)
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Abstract

Chronic alcohol consumption leads to excessive production of reactive oxygen species (ROS), driving oxidative stress that contributes to both alcohol use disorder (AUD) and Alzheimer’s disease (AD). This review explores how ROS-mediated mitochondrial dysfunction and neuroinflammation serve as shared pathological mechanisms linking these conditions. We highlight the role of alcohol-induced oxidative damage in exacerbating neurodegeneration and compare ROS-related pathways in AUD and AD. Finally, we discuss emerging therapeutic strategies, including mitochondrial antioxidants and inflammasome inhibitors, that target oxidative stress to mitigate neurodegeneration. Understanding these overlapping mechanisms may provide new insights for preventing and treating ROS-driven neurodegenerative disorders.
Keywords: reactive oxygen species (ROS); alcohol use disorder (AUD); Alzheimer’s disease (AD) reactive oxygen species (ROS); alcohol use disorder (AUD); Alzheimer’s disease (AD)

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MDPI and ACS Style

Song, H.; Lee, J.; Lee, Y.; Kim, S.; Kang, S. Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications. Int. J. Mol. Sci. 2025, 26, 3272. https://doi.org/10.3390/ijms26073272

AMA Style

Song H, Lee J, Lee Y, Kim S, Kang S. Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications. International Journal of Molecular Sciences. 2025; 26(7):3272. https://doi.org/10.3390/ijms26073272

Chicago/Turabian Style

Song, Hyein, Jiyong Lee, Yeeun Lee, Seungju Kim, and Shinwoo Kang. 2025. "Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications" International Journal of Molecular Sciences 26, no. 7: 3272. https://doi.org/10.3390/ijms26073272

APA Style

Song, H., Lee, J., Lee, Y., Kim, S., & Kang, S. (2025). Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications. International Journal of Molecular Sciences, 26(7), 3272. https://doi.org/10.3390/ijms26073272

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