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Molbank
Volume 2023
Issue 3
10.3390/M1700
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Short Note

4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine

by
Natalia V. Obruchnikova
and
Oleg A. Rakitin
*
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Molbank 2023, 2023(3), M1700; https://doi.org/10.3390/M1700
Submission received: 31 May 2023 / Revised: 10 July 2023 / Accepted: 17 July 2023 / Published: 20 July 2023
(This article belongs to the Collection Heterocycle Reactions)
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Abstract

1,2,5-Oxadiazol-3-amines with a heterocyclic substituent in the 4-position are being intensively investigated as compounds with valuable pharmacological activity. In this communication, the reaction of 1,2,5-oxadiazole-3,4-diamine with 2,5-hexanedione was shown to selectively give 4-(2,5-dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine as a product of the Paal–Knorr reaction. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, 1H and 13C NMR, and IR spectroscopy.
Keywords: 1,2,5-oxadiazoles; 1,2,5-oxadiazole-3,4-diamine; Paal–Knorr reaction; 2,5-hexanedione 1,2,5-oxadiazoles; 1,2,5-oxadiazole-3,4-diamine; Paal–Knorr reaction; 2,5-hexanedione

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MDPI and ACS Style

Obruchnikova, N.V.; Rakitin, O.A. 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine. Molbank 2023, 2023, M1700. https://doi.org/10.3390/M1700

AMA Style

Obruchnikova NV, Rakitin OA. 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine. Molbank. 2023; 2023(3):M1700. https://doi.org/10.3390/M1700

Chicago/Turabian Style

Obruchnikova, Natalia V., and Oleg A. Rakitin. 2023. "4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine" Molbank 2023, no. 3: M1700. https://doi.org/10.3390/M1700

APA Style

Obruchnikova, N. V., & Rakitin, O. A. (2023). 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine. Molbank, 2023(3), M1700. https://doi.org/10.3390/M1700

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