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Volume 22
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10.21775/cimb.022.065
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Far from the Madding Crowd: The Molecular Basis for Immunological Escape of Plasmodium falciparum

by
Manuel E. Patarroyo
1,2,*,
Jorge Aza-Conde
,
Armando Moreno-Vranich
1,
Laura Pabón
1,
Yahson Varela
1 and
Manuel A. Patarroyo
1,3
1
Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia
2
Universidad Nacional de Colombia, Bogotá, Colombia
3
Universidad del Rosario, Bogotá, Colombia
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2017, 22(1), 65-78; https://doi.org/10.21775/cimb.022.065
Submission received: 2 August 2016 / Revised: 6 September 2016 / Accepted: 8 September 2016 / Published: 5 October 2016

Abstract

Like Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite’s most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induce.

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MDPI and ACS Style

Patarroyo, M.E.; Aza-Conde, J.; Moreno-Vranich, A.; Pabón, L.; Varela, Y.; Patarroyo, M.A. Far from the Madding Crowd: The Molecular Basis for Immunological Escape of Plasmodium falciparum. Curr. Issues Mol. Biol. 2017, 22, 65-78. https://doi.org/10.21775/cimb.022.065

AMA Style

Patarroyo ME, Aza-Conde J, Moreno-Vranich A, Pabón L, Varela Y, Patarroyo MA. Far from the Madding Crowd: The Molecular Basis for Immunological Escape of Plasmodium falciparum. Current Issues in Molecular Biology. 2017; 22(1):65-78. https://doi.org/10.21775/cimb.022.065

Chicago/Turabian Style

Patarroyo, Manuel E., Jorge Aza-Conde, Armando Moreno-Vranich, Laura Pabón, Yahson Varela, and Manuel A. Patarroyo. 2017. "Far from the Madding Crowd: The Molecular Basis for Immunological Escape of Plasmodium falciparum" Current Issues in Molecular Biology 22, no. 1: 65-78. https://doi.org/10.21775/cimb.022.065

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