Is Aberrant DNA Methylation a Key Factor in Molar Incisor Hypomineralization?

Round 1

Reviewer 1 Report

This paper addresses an interesting clinical problem. Regarding the material and the methods section, it is not clear what the inclusion and exclusion criteria were for both the control and the sample. As the authors have mentioned the sample is relatively small.  Moreover, the sample and controls should have been matched more appropriately. Also, it has not been clarified if the clinical examination has been performed by the same clinician or not.

 

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

Block citation should be avoided – maximum 3 together is enough

Some English expression should be revised for example line 29 31 is weak ; the same “Despite many years of research, it is still the subject of many studies”   . therefore I suggest please revise the entire manuscript for poor English

The introduction should be more structured and clearly indicate the authors contribution and scientific novelty

From figure 2 and 3 it is difficult to make actually a proper correlation as there is very much dispersion !

From discussion it was found difficult to understand which is the authors finding from this work. As there was not a clear indication to be considered rather only a statement that this work is  novel approach to the MIH etiology. It is expected that the authors clearly prove their findings and assumptions.

The conclusion are very superficial and not linked to the results

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

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This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.