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Article

Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction

by
Imane Boukhers
1,
Sylvie Morel
2,
Joelle Kongolo
1,
Romain Domingo
1,
Adrien Servent
1,
Lea Ollier
1,
Hippolyte Kodja
1,
Thomas Petit
3 and
Patrick Poucheret
1,*
1
Qualisud, Univ Montpellier, Avignon Université, CIRAD, Institut Agro, IRD, Université de La Réunion, 97400 Montpellier, France
2
Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS-Université de Montpellier-Université Paul-Valéry Montpellier-EPHE-IRD, 34093 Montpellier, France
3
Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion, 34093 Sainte-Clotilde, France
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2023, 45(9), 6967-6985; https://doi.org/10.3390/cimb45090440
Submission received: 4 August 2023 / Revised: 18 August 2023 / Accepted: 21 August 2023 / Published: 22 August 2023
(This article belongs to the Special Issue The Role of Bioactives in Inflammation)
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Abstract

Sweet potato (SP), Ipomoea batatas Lam, belongs to the Convolvulaceae family. It produces edible storage roots. Currently, orange varieties contribute to improving food systems and managing vitamin A deficiency. Processing of this food crop into flour allows better conservation. However, nutrition health data regarding SP flour obtained by green extraction remains scarce. In this study, we therefore explored its phytochemistry and its associated bioactivity potential for human health. We analyzed the nutritional composition of orange flesh sweet potato (OFSP) flour and assessed the antioxidant (free radical scavenging) and immunomodulatory (on inflammatory murine macrophages) properties of the extract. More specifically, we measured the impact of OFSP flour extract on mediators such as Nitric Oxide (NO) and the production of pro-inflammatory cytokines such as Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-alpha), Monocyte Chemoattractant Protein-1 (MCP-1), and Prostaglandin-E2 (PGE-2). Our results indicated significant fiber, mineral, beta-carotene, and polyphenols content in the extracts, and antioxidant and immunomodulatory bioactivities were also demonstrated with a concentration-dependent inhibition of cytokine production. Taken together, our results suggest that Ipomoea batatas flour could, in addition to being a good source of energy and beta-carotene provitamin A, constitute a food of interest for the prophylaxis of metabolic diseases associated with an underlying low-grade inflammatory state.
Keywords: orange flesh sweet potato flour; phenolic compounds; beta-carotene; antioxidant activity; anti-inflammatory activity; chronic metabolic diseases orange flesh sweet potato flour; phenolic compounds; beta-carotene; antioxidant activity; anti-inflammatory activity; chronic metabolic diseases
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MDPI and ACS Style

Boukhers, I.; Morel, S.; Kongolo, J.; Domingo, R.; Servent, A.; Ollier, L.; Kodja, H.; Petit, T.; Poucheret, P. Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction. Curr. Issues Mol. Biol. 2023, 45, 6967-6985. https://doi.org/10.3390/cimb45090440

AMA Style

Boukhers I, Morel S, Kongolo J, Domingo R, Servent A, Ollier L, Kodja H, Petit T, Poucheret P. Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction. Current Issues in Molecular Biology. 2023; 45(9):6967-6985. https://doi.org/10.3390/cimb45090440

Chicago/Turabian Style

Boukhers, Imane, Sylvie Morel, Joelle Kongolo, Romain Domingo, Adrien Servent, Lea Ollier, Hippolyte Kodja, Thomas Petit, and Patrick Poucheret. 2023. "Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction" Current Issues in Molecular Biology 45, no. 9: 6967-6985. https://doi.org/10.3390/cimb45090440

APA Style

Boukhers, I., Morel, S., Kongolo, J., Domingo, R., Servent, A., Ollier, L., Kodja, H., Petit, T., & Poucheret, P. (2023). Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction. Current Issues in Molecular Biology, 45(9), 6967-6985. https://doi.org/10.3390/cimb45090440

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