Diagnostic and Prognostic Role of Circulating microRNAs in Patients with Coronary Artery Disease—Impact on Left Ventricle and Arterial Function
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Sample Collection and RNA Extraction
2.3. Echocardiography
2.4. Arterial Function
2.5. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Echocardiographic and Arterial Stiffness Parameters
3.3. Circulating MicroRNAs and MMPs
3.4. Correlations
4. Discussion
4.1. Limitations
4.2. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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General Characteristics | STEMI (n = 60) | SIHD (n = 30) | p-Value |
---|---|---|---|
Age (years) | 57.3 ± 13.4 | 61.1 ± 10.6 | 0.19 |
Male/female (n/n) | 43/17 | 18/12 | 0.26 |
BMI (kg/m2) | 28.0 ± 4.1 | 28.5 ± 3.5 | 0.54 |
SBP (mmHg) | 129.8 ± 22.9 | 134.3 ± 16.9 | 0.35 |
DBP (mmHg) | 76.6 ± 9.4 | 80.2 ± 9.8 | 0.09 |
Heart rate (beats/min) | 75.9 ± 12.1 | 67.4 ± 11.5 | 0.02 |
Cardiovascular risk factors | |||
Current smoker (%) | 50.0 | 10.0 | 0.001 |
Hypertension (%) | 73.3 | 96.7 | 0.008 |
Type 2 diabetes (%) | 50.0 | 26.7 | 0.035 |
Dyslipidaemia (%) | 88.3 | 100 | 0.05 |
Parameter | STEMI (n = 60) | SIHD (n = 30) | p-Value |
---|---|---|---|
2D LVEDV (mL) | 124.4 ± 34.5 | 120.4 ± 34.1 | 0.60 |
2D LVESV (mL) | 71.9 ± 27.6 | 61.5 ± 23.8 | 0.08 |
2D LVEF (%) | 42.0 ± 8.9 | 49.6 ± 7.6 | 0.0001 |
MAPSE (mm) | 12.5 ± 6 | 13.6 ± 2.1 | 0.32 |
TDI Smi_m (cm/s) | 6.8 ± 1.5 | 6.7 ± 1.2 | 0.88 |
TDI Smi_l (cm/s) | 7.4 ± 2.3 | 7.9 ± 2.0 | 0.28 |
2D RS (%) | 16.1 ± 8.4 | 21.3 ± 9.0 | 0.011 |
2D CS (%) | 12.7 ± 3.7 | 14.3 ± 3.8 | 0.06 |
2D LS (%) | 10.0 ± 3.8 | 14.1 ± 3.1 | 0.0001 |
3D LVEDV (mL) | 111.3 ± 27.7 | 103.7 ± 28.6 | 0.25 |
3D LVESV (mL) | 62.9 ± 21.5 | 52.2 ± 20.0 | 0.31 |
3D LVEF (%) | 44.3 ± 7.4 | 50.6 ± 7.2 | 0.0001 |
3D RS (%) | 16.6 ± 8.9 | 18.4 ± 8.7 | 0.37 |
3D CS (%) | 7.4 ± 3.3 | 8.4 ± 3.6 | 0.21 |
3D LS (%) | 6.5 ± 3.4 | 6.8 ± 3.3 | 0.72 |
IMT (mm) | 0.8 ± 0.2 | 0.8 ± 0.2 | 0.52 |
Ep (kPa) | 131.7 ± 56.4 | 142.7 ± 61.2 | 0.42 |
β index | 10.0 ± 3.9 | 11.3 ± 4.8 | 0.20 |
AC (mm2/kPa) | 0.7 ± 0.3 | 0.7 ± 0.4 | 0.99 |
AIX (%) | 4.4 ± 24.3 | 12.3 ± 14.3 | 0.12 |
RCAVI | 9.3 ± 1.9 | 8.9 ± 1.7 | 0.36 |
LCAVI | 9.3 ± 1.9 | 8.9 ± 1.5 | 0.32 |
RABI | 0.9 ± 0.17 | 0.9 ± 0.1 | 0.92 |
LABI | 1.0 ± 0.1 | 1.0 ± 0.2 | 0.98 |
Parameter | miR126 | miR146 | miR21 | MMP1 | MMP9 | |
---|---|---|---|---|---|---|
Pearson correlation (R) and p-value | STEMI | |||||
2D LVEDV (mL) | R = −0.03, p = 0.81 | R = 0.05, p = 0.71 | R = 0.13, p = 0.36 | R = 0.03, p = 0.82 | R = 0.08, p = 0.53 | |
2D LVESV (mL) | R = 0.01, p = 0.94 | R = −0.02, p = 0.86 | R = 0.09, p = 0.51 | R = 0.11, p = 0.38 | R = 0.11, p = 0.40 | |
2D LVEF (%) | R = −0.33, p = 0.01 | R = 0.15, p = 0.26 | R = −0.07, p = 0.63 | R = −0.27, p = 0.04 | R = −0.40, p = 0.001 | |
MAPSE (mm) | R = 0.35, p = 0.009 | R = −0.02, p = 0.86 | R = 0.10, p = 0.49 | R = 0.09, p = 0.46 | R = 0.33, p = 0.009 | |
TDI Smi_m (cm/s) | R = −0.23, p = 0.08 | R = 0.17, p = 0.23 | R = −0.02, p = 0.86 | R = −0.23, p = 0.08 | R = −0.14, p = 0.29 | |
TDI Smi_l (cm/s) | R = 0.04, p = 0.74 | R = 0.25, p = 0.06 | R = 0.26, p = 0.08 | R = −0.18, p = 0.16 | R = −0.03, p = 0.79 | |
2D RS (%) | R = −0.20, p = 0.13 | R = 0.07, p = 0.59 | R = 0.02, p = 0.89 | R = −0.18, p = 0.18 | R = −0.26, p = 0.05 | |
2D CS (%) | R = −0.04, p = 0.73 | R = 0.03, p = 0.79 | R = 0.04, p = 0.76 | R = −0.02, p = 0.83 | R = −0.09, p = 0.47 | |
2D LS (%) | R = −0.13, p = 0.33 | R = 0.02, p = 0.85 | R = −0.08, p = 0.56 | R = −0.27, p = 0.03 | R = −0.26, p = 0.04 | |
3D LVEDV (mL) | R = −0.02, p = 0.83 | R = 0.00, p = 0.99 | R = 0.02, p = 0.86 | R = 0.04, p = 0.79 | R = 0.08, p = 0.58 | |
3D LVESV (mL) | R = 0.03, p = 0.80 | R = 0.00, p = 0.97 | R = 0.07, p = 0.63 | R = 0.05, p = 0.71 | R = 0.09, p = 0.52 | |
3D LVEF (%) | R = −0.11, p = 0.43 | R = −0.02, p = 0.86 | R = −0.18, p = 0.26 | R = −0.07, p = 0.60 | R = −0.14, p = 0.33 | |
3D RS (%) | R = −0.25, p = 0.08 | R = −0.10, p = 0.49 | R = −0.28, p = 0.08 | R = −0.21, p = 0.16 | R = −0.30, p = 0.03 | |
3D CS (%) | R = −0.31, p = 0.03 | R = −0.04, p = 0.77 | R = −0.25, p = 0.11 | R = −0.19, p = 0.19 | R = −0.31, p = 0.03 | |
3D LS (%) | R = −0.16, p = 0.27 | R = −0.18, p = 0.23 | R = −0.32, p = 0.04 | R = −0.19, p = 0.20 | R = −0.22, p = 0.12 | |
IMT (mm) | R = 0.21, p = 0.13 | R = 0.02, p = 0.85 | R = −0.17, p = 0.29 | R = 0.22, p = 0.12 | R = 0.17, p = 0.24 | |
Ep (kPa) | R = 0.05, p = 0.72 | R = 0.09, p = 0.53 | R = 0.15, p = 0.32 | R = 0.10, p = 0.47 | R = 0.11, p = 0.40 | |
β index | R = 0.03, p = 0.78 | R = 0.02, p = 0.84 | R = −0.33, p = 0.01 | R = 0.06, p = 0.65 | R = 0.12, p = 0.36 | |
AC (mm2/kPa) | R = −0.09, p = 0.52 | R = −0.07, p = 0.63 | R = 0.13, p = 0.40 | R = −0.06, p = 0.66 | R = 0.00, p = 0.94 | |
AIX (%) | R = 0.07, p = 0.71 | R = 0.01, p = 0.94 | R = −0.21, p = 0.17 | R = 0.05, p = 0.72 | R = −0.01, p = 0.92 | |
RCAVI | R = 0.32, p = 0.01 | R = 0.07, p = 0.58 | R = 0.07, p = 0.62 | R = 0.16, p = 0.22 | R = 0.18, p = 0.15 | |
LCAVI | R = 0.32, p = 0.01 | R = 0.08, p = 0.53 | R = 0.15, p = 0.29 | R = 0.11, p = 0.40 | R = 0.14, p = 0.27 | |
RABI | R = −0.02, p = 0.84 | R = 0.17, p = 0.23 | R = 0.14, p = 0.32 | R = −0.07, p = 0.57 | R = 0.01, p = 0.93 | |
LABI | R = −0.02, p = 0.83 | R = 0.13, p = 0.38 | R = 0.09, p = 0.52 | R = −0.11, p = 0.41 | R = −14, p = 0.27 | |
Pearson correlation (R) and p-value | SIHD | |||||
2D LVEDV (mL) | R = 0.07, p = 0.78 | R = 0.06, p = 0.75 | R = −0.15, p = 0.41 | R = −10, p = 0.60 | R = 0.15, p = 0.41 | |
2D LVESV (mL) | R = −0.04, p = 0.98 | R = −0.01, p = 0.93 | R = −0.11, p = 0.55 | R = 0.05, p = 0.80 | R = 0.19, p = 0.32 | |
2D LVEF (%) | R = 0.06, p = 0.73 | R = 0.07, p = 0.70 | R = 0.04, p = 0.98 | R = −0.29, p = 0.15 | R = −0.08, p = 0.68 | |
MAPSE (mm) | R = 0.41, p = 0.02 | R = 0.23, p = 0.24 | R = −0.37, p = 0.04 | R = −0.29, p = 0.14 | R = −0.04, p = 0.82 | |
TDI Smi_m (cm/s) | R = 0.08, p = 0.64 | R = 0.24, p = 0.22 | R = 0.06, p = 0.73 | R = −0.25, p = 0.20 | R = 0.03, p = 0.87 | |
TDI Smi_l (cm/s) | R = 0.00, p = 0.99 | R = 0.00, p = 0.98 | R = 0.−29, p = 0.11 | R = −0.09, p = 0.65 | R = 0.08, p = 0.68 | |
2D RS (%) | R = −0.14, p = 0.47 | R = 0.11, p = 0.56 | R = −0.01, p = 0.94 | R = −0.18, p = 0.37 | R = −0.21, p = 0.29 | |
2D CS (%) | R = −0.004, p = 0.98 | R = 0.05, p = 0.77 | R = −0.13, p = 0.47 | R = −0.26, p = 0.20 | R = 0.14, p = 0.48 | |
2D LS (%) | R = 0.23, p = 0.21 | R = 0.27, p = 0.16 | R = −0.19, p = 0.30 | R = −0.11, p = 0.56 | R = −0.02, p = 0.88 | |
3D LVEDV (mL) | R = −0.03, p = 0.86 | R = −0.07, p = 0.73 | R = −0.30, p = 0.10 | R = −0.14, p = 0.48 | R = 0.17, p = 0.37 | |
3D LVESV (mL) | R = −0.07, p = 0.71 | R = −0.14, p = 0.47 | R = −0.26, p = 0.16 | R = 0.02, p = 0.91 | R = 0.23, p = 0.23 | |
3D LVEF (%) | R = 0.07, p = 0.71 | R = 0.18, p = 0.35 | R = 0.13, p = 0.48 | R = −0.28, p = 0.16 | R = −0.25, p = 0.19 | |
3D RS (%) | R = −0.13, p = 0.47 | R = 0.24, p = 0.21 | R = 0.50, p = 0.005 | R = 0.02, p = 0.91 | R = −0.06, p = 0.76 | |
3D CS (%) | R = −0.16, p = 0.40 | R = 0.26, p = 0.18 | R = 0.46, p = 0.009 | R = 0.02, p = 0.91 | R = −0.05, p = 0.77 | |
3D LS (%) | R = −0.05, p = 0.78 | R = −25, p = 0.19 | R = 0.40, p = 0.02 | R = −0.003, p = 0.99 | R = −0.37, p = 0.85 | |
IMT (mm) | R = 0.24, p = 0.23 | R = 0.15, p = 0.48 | R = −0.02, p = 0.88 | R = 0.18, p = 0.40 | R = −0.08, p = 0.70 | |
Ep (kPa) | R = −0.21, p = 0.29 | R = −0.13, p = 0.52 | R = −0.09, p = 0.63 | R = 0.17, p = 0.42 | R = −0.02, p = 0.89 | |
β index | R = −0.18, p = 0.37 | R = −0.04, p = 0.85 | R = −0.13, p = 0.51 | R = 0.08, p = 0.69 | R = −0.08, p = 0.70 | |
AC (mm2/kPa) | R = 0.27, p = 0.16 | R = 0.18, p = 0.37 | R = 0.09, p = 0.63 | R = −0.17, p = 0.43 | R = −0.13, p = 0.51 | |
AIX (%) | R = −0.001, p = 0.99 | R = −0.07, p = 0.73 | R = −0.04, p = 0.84 | R = −0.26, p = 0.21 | R = −0.16, p = 0.42 | |
RCAVI | R = −0.25, p = 0.18 | R = −0.34, p = 0.07 | R = −0.11, p = 0.55 | R = 0.16, p = 0.41 | R = 0.32, p = 0.04 | |
LCAVI | R = −0.27, p = 0.15 | R = −0.28, p = 0.15 | R = −0.05, p = 0.76 | R = 0.09, p = 0.63 | R = 0.40, p = 0.03 | |
RABI | R = −0.40, p = 0.03 | R = 0.16, p = 0.41 | R = 0.07, p = 0.70 | R = 0.08, p = 0.66 | R = −0.14, p = 0.45 | |
LABI | R = −0.39, p = 0.03 | R = 0.17, p = 0.37 | R = 0.16, p = 0.38 | R = 0.19, p = 0.35 | R = −0.06, p = 0.76 |
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Iacobescu, L.; Ciobanu, A.O.; Macarie, R.; Vadana, M.; Ciortan, L.; Tucureanu, M.M.; Butoi, E.; Simionescu, M.; Vinereanu, D. Diagnostic and Prognostic Role of Circulating microRNAs in Patients with Coronary Artery Disease—Impact on Left Ventricle and Arterial Function. Curr. Issues Mol. Biol. 2024, 46, 8499-8511. https://doi.org/10.3390/cimb46080500
Iacobescu L, Ciobanu AO, Macarie R, Vadana M, Ciortan L, Tucureanu MM, Butoi E, Simionescu M, Vinereanu D. Diagnostic and Prognostic Role of Circulating microRNAs in Patients with Coronary Artery Disease—Impact on Left Ventricle and Arterial Function. Current Issues in Molecular Biology. 2024; 46(8):8499-8511. https://doi.org/10.3390/cimb46080500
Chicago/Turabian StyleIacobescu, Loredana, Andrea Olivia Ciobanu, Razvan Macarie, Mihaela Vadana, Letitia Ciortan, Monica Madalina Tucureanu, Elena Butoi, Maya Simionescu, and Dragos Vinereanu. 2024. "Diagnostic and Prognostic Role of Circulating microRNAs in Patients with Coronary Artery Disease—Impact on Left Ventricle and Arterial Function" Current Issues in Molecular Biology 46, no. 8: 8499-8511. https://doi.org/10.3390/cimb46080500