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Volume 51
Issue 5
10.1016/j.medici.2015.08.002
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Article

Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking

by
Jurgita Jackutė
1,*,
Marius Žemaitis
1,
Darius Pranys
2,
Brigita Šitkauskienė
1,
Skaidrius Miliauskas
1,
Vytis Bajoriūnas
3 and
Raimundas Sakalauskas
1
1
Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2
Department of Pathology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3
Department of Cardiac, Thoracic and Vascular Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2015, 51(5), 263-271; https://doi.org/10.1016/j.medici.2015.08.002
Submission received: 21 May 2015 / Accepted: 31 August 2015 / Published: 21 September 2015
Versions Notes

Abstract

Background and objective: The immune system plays an important role in non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the infiltration patterns of CD4+ and CD8+ T cells in NSCLC and to analyze their relation to COPD, smoking status and other clinicopathologic variables.
Materials and methods: Lung tissue specimens from 50 patients who underwent surgery for NSCLC (stages I–III) and 10 control group subjects were analyzed immunohistochemically.
Results: NSCLC patients had a greater number of CD4+ and CD8+ T cells infiltrating the lung tissue than the control group (P = 0.001) with predominant infiltration in the tumor stroma. We found a significant association between the number of total and tumor stroma-infiltrating CD4+ and CD8+ T cells, and smoking status (P < 0.05). There were more CD8+ T cells in the tumor stroma and fewer in the tumor islets in NSCLC patients with COPD as compared to NSCLC patients without COPD (P < 0.05). However, there was no such association between CD4+ T cells and COPD status. A high level of CD8+ T cell infiltration in the tumor stroma was independently associated with the coexistence of COPD in multivariate analysis (P < 0.05).
Conclusions: According to our data, COPD but not smoking seems to be associated with higher infiltration of CD8+ T cells in the tumor stroma of patients with NSCLC. It allows us to hypothesize that NSCLC patients with coexisting COPD may have a more favorable outcome due to anticancer properties of stromal CD8+ T cells.
Keywords: Non-small cell lung cancer; Chronic obstructive pulmonary disease; CD4+ T cells; CD8+ T cells; Smoking Non-small cell lung cancer; Chronic obstructive pulmonary disease; CD4+ T cells; CD8+ T cells; Smoking

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MDPI and ACS Style

Jackutė, J.; Žemaitis, M.; Pranys, D.; Šitkauskienė, B.; Miliauskas, S.; Bajoriūnas, V.; Sakalauskas, R. Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking. Medicina 2015, 51, 263-271. https://doi.org/10.1016/j.medici.2015.08.002

AMA Style

Jackutė J, Žemaitis M, Pranys D, Šitkauskienė B, Miliauskas S, Bajoriūnas V, Sakalauskas R. Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking. Medicina. 2015; 51(5):263-271. https://doi.org/10.1016/j.medici.2015.08.002

Chicago/Turabian Style

Jackutė, Jurgita, Marius Žemaitis, Darius Pranys, Brigita Šitkauskienė, Skaidrius Miliauskas, Vytis Bajoriūnas, and Raimundas Sakalauskas. 2015. "Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking" Medicina 51, no. 5: 263-271. https://doi.org/10.1016/j.medici.2015.08.002

APA Style

Jackutė, J., Žemaitis, M., Pranys, D., Šitkauskienė, B., Miliauskas, S., Bajoriūnas, V., & Sakalauskas, R. (2015). Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking. Medicina, 51(5), 263-271. https://doi.org/10.1016/j.medici.2015.08.002

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