Effect of Quinolones Versus Cefixime on International Normalized Ratio Levels After Valve Replacement Surgery with Warfarin Therapy
Abstract
:1. Introduction
2. Material and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Bleeding Definition | Sternal Closure Delayed | Postoperative Chest Tube Blood Loss within 12 h (mL) | PRBC (units) | FFP (units) | PLT (units) | Cryoprecipitate | PCCs | rFVIIa | Reexploration/Tamponade |
---|---|---|---|---|---|---|---|---|---|
Class 0 (insignificant) | No | <600 | 0 * | 0 | 0 | No | No | No | No |
Class 1 (mild) | No | 601–800 | 1 | 0 | 0 | No | No | No | No |
Class 2 (moderate) | No | 801–1000 | 2–4 | 2–4 | Yes | Yes | Yes | No | No |
Class 3 (severe) | Yes | 1001–2000 | 5–10 | 5–10 | N/A | N/A | N/A | No | Yes |
Class 4 (massive) | N/A | >2000 | >10 | >10 | N/A | N/A | N/A | Yes | N/A |
Gender | Frequency | Percentages |
---|---|---|
Male | 46 | 61.3% |
Female | 29 | 38.7% |
Procedures | Percentages |
---|---|
Aortic valve replacement | 54% |
Mitral valve replacement | 39% |
Double valve replacement | 7% |
Valvular Disease Type | Frequency |
---|---|
Aortic stenosis | 45.3% |
Mitral stenosis | 29.3% |
Mitral regurgitation | 6.7% |
Aortic regurgitation | 5.3% |
Aortic stenosis, mitral stenosis | 5.3% |
Mitral stenosis, mitral regurgitation | 2.7% |
Aortic stenosis, mitral regurgitation, aortic regurgitation | 1.3% |
Aortic stenosis, mitral regurgitation | 1.3% |
Aortic stenosis, aortic regurgitation | 1.3% |
Patient Groups Reference Values | Serum Creatinine (0.5–1.2 mg/dL) | Alanine Transferase (7–55 U/L) | Albumin (35–55 g/L) |
---|---|---|---|
moxifloxacin + warfarin | 0.7268 ± 0.1577 | 32.72 ± 10.10 | 43.28 ± 5.828 |
levofloxacin + warfarin | 0.8644 ± 0.1735 | 27.52 ± 10.85 | 44.28 ± 6.755 |
cefixime + warfarin | 0.7560 ± 0.1751 | 34.64 ± 15.45 | 44.52 ± 6.801 |
INR Without/With Antibiotic Therapy | Mean ± S.D. | |
---|---|---|
INR before moxifloxacin addition | p < 0.001 | |
INR within 7 days of moxifloxacin addition | ||
INR before levofloxacin addition | p < 0.001 | |
INR within 7 days of levofloxacin addition | ||
INR before cefixime addition | p > 0.05 | |
INR within 7 days of cefixime addition |
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Liaqat, A.; Khan, A.-u.; Asad, M.; Khalil, H. Effect of Quinolones Versus Cefixime on International Normalized Ratio Levels After Valve Replacement Surgery with Warfarin Therapy. Medicina 2019, 55, 644. https://doi.org/10.3390/medicina55100644
Liaqat A, Khan A-u, Asad M, Khalil H. Effect of Quinolones Versus Cefixime on International Normalized Ratio Levels After Valve Replacement Surgery with Warfarin Therapy. Medicina. 2019; 55(10):644. https://doi.org/10.3390/medicina55100644
Chicago/Turabian StyleLiaqat, Anam, Arif-ullah Khan, Muhammad Asad, and Hafsa Khalil. 2019. "Effect of Quinolones Versus Cefixime on International Normalized Ratio Levels After Valve Replacement Surgery with Warfarin Therapy" Medicina 55, no. 10: 644. https://doi.org/10.3390/medicina55100644