Lithium Medication in Pregnancy and Breastfeeding—A Case Series
Abstract
:1. Introduction
2. Cases
2.1. Case 1
2.2. Case 2
2.3. Case 3
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gestational Weeks | Lithiumcarbonat LA Daily Dose | Lithium Serum Levels [mmol/L] | Creatinine [mg/dL] | Renal Function, cGFR (MDRD) [mL/min/1.73 m2] |
---|---|---|---|---|
Before pregnancy | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.77 | 0.92 | 74 |
11th | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.47 | N/A | N/A |
13th | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.46 | 0.62 | 116 |
18th | 1200 mg (1 ½ -0-0-1 ½ 400 mg-tablets) | 0.52 | N/A | N/A |
20th | 1400 mg (1 ½ -0-0-2 400 mg-tablets) | 0.58 | N/A | N/A |
24th | 1400 mg (1 ½ -0-0-2 400 mg-tablets ) | 0.56 | 0.70 | 101 |
28th | 1400 mg 1 ½ -0-0-2 400 mg-tablets ) | 0.68 | 0.67 | 101 |
32nd | 1400 mg (1 ½ -0-0-2 400 mg-tablets ) | 0.63 | 0.71 | 99 |
37th | 1400 mg (1 ½ -0-0-2 400 mg-tablets ) | 0.76 | 0.72 | 97 |
Childbirth (38th gestational week) | ||||
1 day pp | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.67 | N/A | N/A |
2 days pp | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.64 | N/A | N/A |
4 days pp | 1000 mg 1-0-0-1½ 400 mg-tablets) | 0.54 | N/A | N/A |
5 days pp | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.66 | N/A | N/A |
7 days pp | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.60 | 0.82 | 84 |
1 month pp | 1000 mg 1-0-0-1½ 400 mg-tablets) | 0.72 mother 0.09 infant Ratio infant maternal serum lithium: 12.5% | ||
2 months pp | 1000 mg (1-0-0-1½ 400 mg-tablets) | 0.89 mother 0.12 infant Ratio infant maternal serum lithium: 13.5% |
Gestational Weeks | Lithium Carbonate LA Daily Dose | Lithium Serum Levels [mmol/L] | Creatinine [mg/dL] | Renal Function, eGFR (MDRD) [mL/min/1.73 m2] |
---|---|---|---|---|
10th | 450 mg (½-0-0-½ 450 mg-tablets) | 0.29 | N/A | N/A |
18th | 450 mg (½-0-0-½ 450 mg-tablets) | 0.17 | 0.49 | >120.0 |
21st | 450 mg (½-0-0-½ 450 mg-tablets) | 0.08 | 0.43 | >120.0 |
32nd | 450 mg (½-0-0-½ 450 mg-tablets) | 0.55 | 0.55 | >120.0 |
36th | 450 mg (½-0-0-½ 450 mg-tablets) | 0.16 | 0.43 | >120.0 |
Childbirth (42nd gestational weeks) | ||||
4 days pp | 450 mg (½-0-0-½ 450 mg-tablets) | 0.2 | N/A | N/A |
11 days pp | 450 mg (½-0-0-½ 450 mg-tablets) | 0.15 | 0.63 | 108.8 |
2 months pp | 450 mg (0-0-0-1 450 mg-tablet) | 0.42 mother <0.01 infant Infant was breastfed in combination with formula approximately 50:50 | 0.71 | 94.8 |
4 months pp | 450 mg (0-0-0-1 450 mg-tablet) | 0.21 | 0.61 | 113 |
Gestational Weeks | Lithium Carbonate LA Daily Dose | Lithium Serum Levels [mmol/L] | Creatinine [mg/dL] | Renal Function, eGFR (MDRD) [mL/min/1.73 m2] |
---|---|---|---|---|
Before pregnancy | 675 mg (0-0-0-1 ½ 450 mg-tablets) | N/A | N/A | N/A |
13th | 675 mg (0-0-0-1 ½ 450 mg-tablets) | 0.71 | N/A | N/A |
16th | 450 mg (0-0-0-1 450 mg-tablet) | 0.65 | 0.81 | 81.9 |
20th | 450 mg (0-0-0-1 450 mg-tablet) | 0.34 | 0.62 | 111.6 |
24th | 450 mg (0-0-0-1 450 mg-tablet) | 0.24 | 0.65 | 105.0 |
28th | 450 mg/day alternating with 675 mg/day every other day (0-0-0-1/1½ 450 mg-tablets) | 0.42 | 0.72 | 93.3 |
31st | 450 mg/day alternating with 675 mg/day every other day (0-0-0-1/1½ 450 mg-tablets) | 0.65 | 0.82 | 80.3 |
39th | 450 mg (0-0-0-1 450 mg-tablet) | 0.93 | 1.2 | N/A |
Childbirth (39th gestational week) | ||||
5 days pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.4 | N/A | N/A |
11 days pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.26 Mother 0.11 Infant Ratio infant maternal serum lithium: 42.3% | N/A | N/A |
3 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.23 Mother <0.5 infant, exact value not available | 0.83 | N/A |
6 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.26 | 0.86 | N/A |
7 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.25 | 0.8 | N/A |
8 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.25 | 0.83 | N/A |
9 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.14 | 0.81 | N/A |
10 month pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.27 | 0.86 | N/A |
16 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.25 | 0.80 | N/A |
19 months pp | 225 mg (0-0-0-1/2 450 mg-tablet) | 0.14 | 0.80 | N/A |
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Gehrmann, A.; Fiedler, K.; Leutritz, A.L.; Koreny, C.; Kittel-Schneider, S. Lithium Medication in Pregnancy and Breastfeeding—A Case Series. Medicina 2021, 57, 634. https://doi.org/10.3390/medicina57060634
Gehrmann A, Fiedler K, Leutritz AL, Koreny C, Kittel-Schneider S. Lithium Medication in Pregnancy and Breastfeeding—A Case Series. Medicina. 2021; 57(6):634. https://doi.org/10.3390/medicina57060634
Chicago/Turabian StyleGehrmann, Andrea, Katrin Fiedler, Anna Linda Leutritz, Carolin Koreny, and Sarah Kittel-Schneider. 2021. "Lithium Medication in Pregnancy and Breastfeeding—A Case Series" Medicina 57, no. 6: 634. https://doi.org/10.3390/medicina57060634