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Medicina, Volume 57, Issue 6

2021 June - 128 articles

Cover Story: Conventional treatment for permanent mature teeth diagnosed with symptomatic irreversible pulpitis is nonsurgical root canal treatment (NSRCT). Contemporary studies on vital pulp therapy (VPT) have suggested it as a less invasive treatment option in such teeth. According to this systematic review, one- to five-year success rates after VPT encompassing full or partial pulpotomy, performed with hydraulic calcium silicate-based cements, range from 78% to 90%. Two reports suggest comparable outcomes of pulpotomy and NSRCT. Universal case selection and outcome criteria need to be established for VPT when considered as an alternative to NSRCT. View this paper
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Articles (128)

  • Article
  • Open Access
15 Citations
3,965 Views
13 Pages

A Bibliometric Analysis of Fragility Fractures: Top 50

  • Nicolas Vuillemin,
  • Hans-Christoph Pape,
  • Pol Maria Rommens,
  • Kurt Lippuner,
  • Klaus-Arno Siebenrock,
  • Marius Johann Keel and
  • Johannes Dominik Bastian

21 June 2021

Background and Objectives: The population is aging and fragility fractures are a research topic of steadily growing importance. Therefore, a systematic bibliometric review was performed to identify the 50 most cited articles in the field of fragility...

  • Review
  • Open Access
19 Citations
6,327 Views
12 Pages

Obstructive Sleep Apnea and Periodontal Disease: A Systematic Review

  • Daniela Lembo,
  • Francesco Caroccia,
  • Chiara Lopes,
  • Francesco Moscagiuri,
  • Bruna Sinjari and
  • Michele D’Attilio

21 June 2021

Background and Objectives: The objective of this study was to evaluate the association between periodontal disease and obstructive sleep apnea syndrome (OSAS). Materials and Methods: Electronic search using PubMed, Scopus, LILACS, and Cochrane librar...

  • Review
  • Open Access
17 Citations
6,945 Views
10 Pages

Neutropenic Enterocolitis and Sepsis: Towards the Definition of a Pathologic Profile

  • Giuseppe Bertozzi,
  • Aniello Maiese,
  • Giovanna Passaro,
  • Alberto Tosoni,
  • Antonio Mirijello,
  • Stefania De Simone,
  • Benedetta Baldari,
  • Luigi Cipolloni and
  • Raffaele La Russa

20 June 2021

Background: Neutropenic enterocolitis (NE), which in the past was also known as typhlitis or ileocecal syndrome for the segment of the gastrointestinal tract most affected, is a nosological entity that is difficult to diagnose and whose pathogenesis...

  • Article
  • Open Access
4,691 Views
12 Pages

19 June 2021

Background and Objectives: Ultrasound (US)-guided cervical selective nerve root block (SNRB) is a widely used treatment for upper limb radicular pain. The long thoracic nerve (LTN) passes through the middle scalene muscle (MSM) at the C7 level. The n...

  • Review
  • Open Access
16 Citations
5,112 Views
16 Pages

19 June 2021

Tumor chemosensitivity assays (TCAs), also known as drug response assays or individualized tumor response tests, have been gaining attention over the past few decades. Although there have been strong positive correlations between the results of these...

  • Article
  • Open Access
2 Citations
9,739 Views
8 Pages

Mild Fetal Tricuspid Regurgitation in the First Trimester as a Predictor of Perinatal Outcomes

  • Ji-Eun Park,
  • Hyen-Chul Jo,
  • Seon-Mi Lee,
  • Jong-Chul Baek,
  • In-Ae Cho and
  • Soon-Ae Lee

19 June 2021

Background and Objectives: This study aimed to investigate whether mild fetal tricuspid regurgitation (TR) at 11+ 0 to 13+ 6 weeks of gestation affects perinatal outcomes. Since fetal right ventricular load is associated with placental resistance, we...

  • Article
  • Open Access
6 Citations
3,047 Views
7 Pages

Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis

  • Kenta Torigoe,
  • Kumiko Muta,
  • Kiyokazu Tsuji,
  • Ayuko Yamashita,
  • Miki Torigoe,
  • Shinichi Abe,
  • Yuki Ota,
  • Hiroshi Mukae and
  • Tomoya Nishino

18 June 2021

Background and Objectives: Urinary levels of dickkopf-3 (DKK-3) are associated with poor renal survival in patients with non-dialytic chronic kidney disease. However, it remains unknown whether urinary DKK-3 levels can predict residual renal function...

  • Article
  • Open Access
8 Citations
3,544 Views
10 Pages

The Riga East University Hospital Stroke Registry—An Analysis of 4915 Consecutive Patients with Acute Stroke

  • Guntis Karelis,
  • Madara Micule,
  • Evija Klavina,
  • Iveta Haritoncenko,
  • Ilga Kikule,
  • Biruta Tilgale and
  • Inese Polaka

18 June 2021

Background and Objectives: A hospital-based stroke registry is a useful tool for systematic analyses of the epidemiology, clinical characteristics, and natural course of stroke. Analyses of stroke registry data can provide information that can be use...

  • Case Report
  • Open Access
7 Citations
3,933 Views
8 Pages

18 June 2021

Background: The association of coronavirus disease 2019 (COVID-19) with hypertension has been one of the frequently discussed topics in current studies since hypertension was identified as a risk factor for coronavirus disease. However, no studies se...

  • Case Report
  • Open Access
5 Citations
5,892 Views
9 Pages

Lithium Medication in Pregnancy and Breastfeeding—A Case Series

  • Andrea Gehrmann,
  • Katrin Fiedler,
  • Anna Linda Leutritz,
  • Carolin Koreny and
  • Sarah Kittel-Schneider

18 June 2021

Lithium salts are the first-line prophylaxis treatment for bipolar disorder in most guidelines. The majority of bipolar women are treated with mood stabilizers at the time they wish to get pregnant. One reason for this is the rising average age at fi...

  • Article
  • Open Access
9 Citations
2,985 Views
12 Pages

17 June 2021

Background and Objectives: The aim of this study was to investigate parameters that can be used to predict mortality in patients diagnosed with COVID-19 in the emergency department (ED). Materials and Methods: Patients diagnosed with COVID-19 in the...

  • Article
  • Open Access
12 Citations
4,326 Views
10 Pages

17 June 2021

Background and Objectives: The aim of this study was to assess the effects of physiotherapy with aerobic exercise together with temporomandibular joint range of motion exercises (supervised) and physiotherapy with aerobic exercise only (unsupervised)...

  • Article
  • Open Access
4 Citations
3,405 Views
10 Pages

On the Track of New Endoscopic Alternatives for the Treatment of Selected Gastric GISTs—A Pilot Study

  • Artur Raiter,
  • Katarzyna M. Pawlak,
  • Katarzyna Kozłowska-Petriczko,
  • Jan Petriczko,
  • Joanna Szełemej and
  • Anna Wiechowska-Kozłowska

16 June 2021

Background and Objectives: GISTs (Gastrointestinal stromal tumors) are the most common mesenchymal gastrointestinal tract tumours and are mainly located in the stomach. Their malignant potential depends on size, location, and type. Endoscopic techniq...

  • Case Report
  • Open Access
20 Citations
7,731 Views
9 Pages

16 June 2021

Oro-antral communication (OAC) acts as a pathway for bacteria between the maxillary sinus and oral cavity, and is a common complication after the removal of a dental implant or extraction of a tooth from the maxillary posterior area. In the case of a...

  • Article
  • Open Access
5 Citations
3,142 Views
15 Pages

The Relationship between Affect Integration and Psychopathology in Patients with Personality Disorder: A Cross-Sectional Study

  • Christina Frederiksen,
  • Ole André Solbakken,
  • Rasmus Wentzer Licht,
  • Carsten René Jørgensen,
  • Maria Rodrigo-Domingo and
  • Gry Kjaersdam Telléus

16 June 2021

Background and Objectives: Emotional dysfunction is considered a key component in personality disorders; however, only few studies have examined the relationship between the two. In this study, emotional dysfunction was operationalized through the Af...

  • Systematic Review
  • Open Access
19 Citations
4,045 Views
9 Pages

Central Serous Chorioretinopathy and Personality Characteristics: A Systematic Review of Scientific Evidence over the Last 10 Years (2010 to 2020)

  • Giovanni Genovese,
  • Alessandro Meduri,
  • Maria Rosaria Anna Muscatello,
  • Sebastiano Gangemi,
  • Clemente Cedro,
  • Antonio Bruno,
  • Pasquale Aragona and
  • Gianluca Pandolfo

16 June 2021

Background and Objectives: to investigate the current state of art in the study of personality disorders in central serous chorioretinopathy (CSC), also taking into account the dimensional approach. Materials and Methods: this systematic review was c...

  • Article
  • Open Access
15 Citations
2,907 Views
10 Pages

Neutrophil-to-Lymphocyte Ratio as an Independent Predictor of In-Hospital Mortality in Patients with Acute Intracerebral Hemorrhage

  • Răzvan Alexandru Radu,
  • Elena Oana Terecoasă,
  • Cristina Tiu,
  • Cristina Ghiță,
  • Alina Ioana Nicula,
  • Andreea Nicoleta Marinescu and
  • Bogdan Ovidiu Popescu

15 June 2021

Background and Objectives: Neutrophil-to-lymphocyte ratio (NLR), a very low cost, widely available marker of systemic inflammation, has been proposed as a potential predictor of short-term outcome in patients with intracerebral hemorrhage (ICH). Meth...

  • Article
  • Open Access
3 Citations
3,230 Views
7 Pages

The Dilemma of Falls in Older Persons: Never Forget to Investigate the Syncope

  • Francesca Perego,
  • Beatrice De Maria,
  • Laura Bagnara,
  • Valeria De Grazia,
  • Mauro Monelli,
  • Matteo Cesari and
  • Laura Adelaide Dalla Vecchia

15 June 2021

Background and objectives: Falls represent a major cause of morbidity, hospitalizations, and mortality in older persons. The identification of risk conditions for falling is crucial. This study investigated the presence of syncope as a possible cause...

  • Feature Paper
  • Article
  • Open Access
8 Citations
8,502 Views
17 Pages

15 June 2021

Background and Objectives: Unstable mixed episodes or rapid switching between opposite affective poles within the scope of short cycles was first characterized in 1967 by S. Mentzos as complex polymorphous states with chaotic overlap of manic and dep...

  • Article
  • Open Access
16 Citations
4,473 Views
8 Pages

Meibomian Gland Dysfunction: Intense Pulsed Light Therapy in Combination with Low-Level Light Therapy as Rescue Treatment

  • Leonidas Solomos,
  • Walid Bouthour,
  • Ariane Malclès,
  • Gabriele Thumann and
  • Horace Massa

14 June 2021

Background and Objectives: Evaporative dry eye disease is frequently associated with meibomian gland dysfunction. Patients are often unhappy because of daily drops, care burden, and suboptimal conventional treatments. In this study, we assessed the e...

  • Case Report
  • Open Access
5 Citations
3,803 Views
7 Pages

Management of a Mycotic Aneurysm in a Patient with COVID-19: A Case Report

  • Muzammil H. Syed,
  • Mark Wheatcroft,
  • Danny Marcuzzi,
  • Hooman Hennessey and
  • Mohammad Qadura

14 June 2021

The aim of this paper is to share our experience in managing a patient with Klebsiella pneumoniae mycotic abdominal aortic aneurysm who was also infected with COVID-19. A 69-year-old male was transferred to our hospital for the management of an infra...

  • Review
  • Open Access
16 Citations
4,241 Views
14 Pages

TGF-β Physiology as a Novel Therapeutic Target Regarding Autoimmune Thyroid Diseases: Where Do We Stand and What to Expect

  • Efstratios Kardalas,
  • Spyridoula Maraka,
  • Maria Papagianni,
  • George Paltoglou,
  • Charalampos Siristatidis and
  • George Mastorakos

14 June 2021

Transforming growth factor beta (TGF-β), as a master regulator of immune response, is deeply implicated in the complex pathophysiology and development of autoimmune thyroid diseases. Based on the close interplay between thyroid autoimmunity and TGF-β...

  • Article
  • Open Access
12 Citations
4,844 Views
14 Pages

13 June 2021

Background and Objectives: The efficacy of hydroxy methyl glutaryl-coenzyme A reductase inhibitors (statins) in reducing the incidence of cardiovascular events pushed the target LDL-cholesterol (LDL-C) levels lower and lower in successive guidelines...

  • Article
  • Open Access
28 Citations
6,593 Views
17 Pages

Relationships between Fitness Status and Match Running Performance in Adult Women Soccer Players: A Cohort Study

  • Lillian Gonçalves,
  • Filipe Manuel Clemente,
  • Joel Ignacio Barrera,
  • Hugo Sarmento,
  • Francisco Tomás González-Fernández,
  • Luiz H. Palucci Vieira,
  • António José Figueiredo,
  • Cain C. T. Clark and
  • J. M. Cancela Carral

13 June 2021

Background and Objectives: The aim of this study was twofold: (i) to analyze the relationships between fitness status (repeated-sprint ability (RSA), aerobic performance, vertical height jump, and hip adductor and abductor strength) and match running...

  • Article
  • Open Access
7 Citations
3,729 Views
10 Pages

The Impact of Personal Thoracic Impedance on Electrical Cardioversion in Patients with Atrial Arrhythmias

  • Seung-Young Roh,
  • Jinhee Ahn,
  • Kwang-No Lee,
  • Yong-Soo Baek,
  • Dong-Hyeok Kim,
  • Dae-In Lee,
  • Jaemin Shim,
  • Jong-Il Choi and
  • Young-Hoon Kim

13 June 2021

Background and Objectives: Direct current cardioversion (DCCV) is a safe and useful treatment for atrial tachyarrhythmias. In the past, the energy delivered in DCCV was decided upon empirically, based only on the type of tachyarrhythmia. This convent...

  • Article
  • Open Access
5 Citations
3,176 Views
8 Pages

Recognition in Emergency Department of Septic Patients at Higher Risk of Death: Beware of Patients without Fever

  • Emanuela Sozio,
  • Alessio Bertini,
  • Giacomo Bertolino,
  • Francesco Sbrana,
  • Andrea Ripoli,
  • Fabio Carfagna,
  • Alessandro Giacinta,
  • Bruno Viaggi,
  • Simone Meini and
  • Carlo Tascini
  • + 1 author

12 June 2021

Background and Objectives: Chances of surviving sepsis increase markedly upon prompt diagnosis and treatment. As most sepsis cases initially show-up in the Emergency Department (ED), early recognition of a septic patient has a pivotal role in sepsis...

  • Article
  • Open Access
20 Citations
4,373 Views
12 Pages

Acceptability of Healthcare Professionals to Get Vaccinated against COVID-19 Two Weeks before Initiation of National Vaccination

  • Athanasia Pataka,
  • Seraphim Kotoulas,
  • Emilia Stefanidou,
  • Ioanna Grigoriou,
  • Asterios Tzinas,
  • Ioanna Tsiouprou,
  • Paul Zarogoulidis,
  • Nikolaos Courcoutsakis and
  • Paraskevi Argyropoulou

12 June 2021

Background and Objectives The greatest challenge vaccines face is that of acceptance from the general population. Healthcare professionals’ (HCPs) recommendations have significant influence on general public vaccination behavior. The aim of this stud...

  • Case Report
  • Open Access
16 Citations
6,042 Views
9 Pages

Management Strategies for Brain Tumors Diagnosed during Pregnancy: A Case Report and Literature Review

  • Reona Shiro,
  • Kosuke Murakami,
  • Masaharu Miyauchi,
  • Yasuhiro Sanada and
  • Noriomi Matsumura

12 June 2021

Background and Objectives: Maternal brain tumors diagnosed during pregnancy are very rare, and their clinical course remains incompletely understood. We recently experienced a case of a brain tumor diagnosed at 30 weeks of gestation, and the treatmen...

  • Review
  • Open Access
17 Citations
7,686 Views
23 Pages

Adolescence, Adulthood and Self-Perceived Halitosis: A Role of Psychological Factors

  • Carmela Mento,
  • Clara Lombardo,
  • Mariacristina Milazzo,
  • Nicholas Ian Whithorn,
  • Montserrat Boronat-Catalá,
  • Pedro J. Almiñana-Pastor,
  • Cristina Sala Fernàndez,
  • Antonio Bruno,
  • Maria Rosaria Anna Muscatello and
  • Rocco Antonio Zoccali

12 June 2021

(1) Background: Halitosis is a frequent condition that affects a large part of the population. It is considered a “social stigma”, as it can determine a number of psychological and relationship consequences that affect people’s lives. The purpose of...

  • Review
  • Open Access
6 Citations
3,894 Views
11 Pages

Is the Right to Abortion at Risk in Times of COVID-19? The Italian State of Affairs within the European Context

  • Gianluca Montanari Vergallo,
  • Raffaella Rinaldi,
  • Valeria Piersanti,
  • Anastasio Tini and
  • Alessandro Del Rio

12 June 2021

The COVID-19 health emergency has thrown the health systems of most European countries into a deep crisis, forcing them to call off and postpone all interventions deemed not essential or life-saving in order to focus most resources on the treatment o...

  • Review
  • Open Access
22 Citations
10,534 Views
9 Pages

11 June 2021

Childhood onset bipolar disorder (CO-BD) presents a panoply of difficulties associated with early recognition and treatment. CO-BD is associated with a variety of precursors and comorbidities that have been inadequately studied, so treatment remains...

  • Article
  • Open Access
4 Citations
3,996 Views
12 Pages

Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients

  • Rima Braukyliene,
  • Kamyar Hedayat,
  • Laura Zajanckauskiene,
  • Martynas Jurenas,
  • Ramunas Unikas,
  • Ali Aldujeli,
  • Osvaldas Petrokas,
  • Vytautas Zabiela,
  • Rasa Steponaviciute and
  • Diana Zaliaduonyte
  • + 5 authors

11 June 2021

Background and Objectives: Serum cortisol has been extensively studied for its role during acute myocardial infarction (AMI). Reports have been inconsistent, with high and low serum cortisol associated with various clinical outcomes. Several publicat...

  • Review
  • Open Access
4 Citations
5,072 Views
9 Pages

Evaluation of Patients with Syncope in the Emergency Department: How to Adjust Pharmacological Therapy

  • Martina Rafanelli,
  • Giuseppe Dario Testa,
  • Giulia Rivasi and
  • Andrea Ungar

11 June 2021

The rate of syncope in the Emergency Department ranges between 0.9 and 1.7%. Syncope is mostly related to a underlying reflex or orthostatic mechanism. A bradycardic or a hypotensive phenotype, may be identified. The latter is the most common and cou...

  • Review
  • Open Access
30 Citations
5,919 Views
30 Pages

NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative Diseases

  • Cinzia Sindona,
  • Giovanni Schepici,
  • Valentina Contestabile,
  • Placido Bramanti and
  • Emanuela Mazzon

11 June 2021

Coronavirus disease 2019 (COVID-19) is a rapidly spreading contagious infectious disease caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that primarily affects the respiratory tract as well as the central nervous...

  • Article
  • Open Access
6 Citations
3,607 Views
10 Pages

Prevalence, Epidemiological Characteristics, and Pharmacotherapy of Coronary Artery Disease among Patients with Atrial Fibrillation: Data from Jo-Fib Study

  • Hanna K. Al-Makhamreh,
  • Mohammed Q. Al-Sabbagh,
  • Ala’ E. Shaban,
  • Abdelrahman F. Obiedat and
  • Ayman J. Hammoudeh

11 June 2021

Background and Objectives: Patients with AF are at increased risk for Coronary Artery Disease (CAD) owing to their shared etiologies and risk factors. This study aimed to assess the prevalence, cardiovascular risk factors, and used medications of CAD...

  • Article
  • Open Access
3 Citations
3,602 Views
10 Pages

Characteristics of Pedaling Muscle Stiffness among Cyclists of Different Performance Levels

  • Isaac López-Laval,
  • Rafel Cirer-Sastre,
  • Francisco Corbi and
  • Sebastian Sitko

11 June 2021

Background and Objectives: The aim of the present study was to compare the impact of an incremental exercise test on muscle stiffness in the rectus femoris (RF), vastus lateralis (VL), biceps femoris (BF), and gastrocnemius (GL) among road cyclists o...

  • Case Report
  • Open Access
7 Citations
3,485 Views
7 Pages

Refractory Dry Eye Syndrome after Transconjunctival Excision of the Palpebral Lobe of the Lacrimal Gland

  • Yong-Jae Lee,
  • Han-Sol Choi,
  • Seong-Jun Park,
  • Hae-Jung Sun and
  • Sun-Young Jang

11 June 2021

The aim of the present study was to report two cases of refractory dry eye syndrome (DES) after transconjunctival excision of the palpebral lobe of the lacrimal gland. A 25-year-old female patient with a chief complaint of a palpable mass in both upp...

  • Systematic Review
  • Open Access
25 Citations
4,599 Views
12 Pages

A Review of the Significance in Measuring Preoperative and Postoperative Carcinoembryonic Antigen (CEA) Values in Patients with Medullary Thyroid Carcinoma (MTC)

  • Ioannis Passos,
  • Elisavet Stefanidou,
  • Soultana Meditskou-Eythymiadou,
  • Maria Mironidou-Tzouveleki,
  • Vasiliki Manaki,
  • Vasiliki Magra,
  • Styliani Laskou,
  • Stylianos Mantalovas,
  • Stelian Pantea and
  • Konstantinos Sapalidis
  • + 1 author

11 June 2021

Background and Objectives: Medullary thyroid carcinoma (MTC) accounts for 1–2% of all thyroid malignancies, and it originates from parafollicular “C” cells. Carcinoembryonic antigen (CEA) is a tumor marker, mainly for gastrointestinal malignancies. T...

  • Case Report
  • Open Access
3 Citations
3,719 Views
6 Pages

11 June 2021

The long-term administration of vancomycin has increased; however, the pulmonary adverse reactions of long-term vancomycin treatment remain under-studied. A 75-year-old male patient with vertebral osteomyelitis receiving long-term vancomycin therapy...

  • Article
  • Open Access
13 Citations
4,076 Views
17 Pages

11 June 2021

Background and Objectives: Chronic rhinosinusitis (CRS) is a condition that affects as much as 10.9% of the population and, along with presence of nasal polyps, is associated with significant morbidity and decreased quality of life. Studies on molecu...

  • Case Report
  • Open Access
3 Citations
3,356 Views
9 Pages

Severe Coronary Artery Disease in a Person Living with HIV

  • Mircea Bajdechi,
  • Cosmin Mihai,
  • Alexandru Scafa-Udriste,
  • Ali Cherry,
  • Diana Zamfir,
  • Irina Dumitru,
  • Roxana Cernat and
  • Sorin Rugina

10 June 2021

The pathophysiology of accelerated atherosclerosis in people living with Human Immunofediciency virus (HIV) is complex. Coronary artery disease (CAD) has become an important cause of mortality in these patients. They often have atypical symptoms, lea...

  • Communication
  • Open Access
8 Citations
4,194 Views
5 Pages

COVID-19 Pandemic in Rio de Janeiro, Brazil: A Social Inequality Report

  • Yago Bernardo,
  • Denes do Rosario and
  • Carlos Conte-Junior

10 June 2021

Background and Objectives: To perform a retrospective report on the lethality of COVID-19 in different realities in the city of Rio de Janeiro (RJ). Materials and Methods: We accomplished an observational study by collecting the data about total conf...

  • Article
  • Open Access
28 Citations
6,051 Views
9 Pages

Liver Impairment and Hematological Changes in Patients with Chronic Hepatitis C and COVID-19: A Retrospective Study after One Year of Pandemic

  • Bianca Cerbu,
  • Stelian Pantea,
  • Felix Bratosin,
  • Iulia Vidican,
  • Mirela Turaiche,
  • Stefan Frent,
  • Ema Borsi and
  • Iosif Marincu

10 June 2021

Background and Objectives: The COVID-19 pandemic is an ongoing public health emergency. Patients with chronic diseases are at greater risk for complications and poor outcomes. The objective of this study was to investigate the liver function abnormal...

  • Review
  • Open Access
12 Citations
7,902 Views
11 Pages

10 June 2021

Idiopathic inflammatory myositis (IIM) is an umbrella term for diseases of unknown origin that cause muscle inflammation. Dermatomyositis and polymyositis are IIMs that commonly cause interstitial lung disease (ILD). When a patient presents with ILD,...

  • Article
  • Open Access
6 Citations
3,079 Views
12 Pages

Predominant Polarity and Polarity Index of Maintenance Treatments for Bipolar Disorder: A Validation Study in a Large Naturalistic Sample in Italy

  • Umberto Albert,
  • Mirko Manchia,
  • Sofia Burato,
  • Bernardo Carpiniello,
  • Gabriele Di Salvo,
  • Federica Pinna,
  • Gianluca Rosso and
  • Giuseppe Maina

10 June 2021

Background and Objectives: Predominant polarity (PP) may be a useful course specifier in at least a significant proportion of patients with Bipolar Disorder (BD), being associated with several clinically relevant correlates. Emerging evidence suggest...

  • Review
  • Open Access
11 Citations
3,253 Views
11 Pages

Corneal Biomechanical Changes in Third Trimester of Pregnancy

  • Inna Adriana Bujor,
  • Raluca Claudia Iancu,
  • Sînziana Luminiţa Istrate,
  • Emil Ungureanu and
  • George Iancu

10 June 2021

Background and Objectives: There is a clear evidence that pregnancy is associated with high production of sex hormones. During the first, second and third trimester of pregnancy, blood hormones levels increase gradually. Cells with affinity for sex h...

  • Review
  • Open Access
33 Citations
4,290 Views
11 Pages

Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies

  • Yue Shen,
  • Cheng Cheng,
  • Xue Zheng,
  • Yuefei Jin,
  • Guangcai Duan,
  • Mengshi Chen and
  • Shuaiyin Chen

Background and Objectives: Procalcitonin (PCT) is positively associated with the severity of COVID-19 (including severe, critical, or fatal outcomes), but some of the confounding factors are not considered. The aim of this meta-analysis was to estima...

  • Article
  • Open Access
8 Citations
3,041 Views
12 Pages

NELL-1 Increased the Osteogenic Differentiation and mRNA Expression of Spheroids Composed of Stem Cells

  • Jong-Ho Lee,
  • Young-Min Song,
  • Sae-Kyung Min,
  • Hyun-Jin Lee,
  • Hye-Lim Lee,
  • Min-Ji Kim,
  • Yoon-Hee Park,
  • Je-Uk Park and
  • Jun-Beom Park

Background and objectives: NELL-1 is a competent growth factor and it reported to target cells committed to the osteochondral lineage. The secreted, osteoinductive glycoproteins are reported to rheostatically control skeletal ossification. This study...

  • Review
  • Open Access
39 Citations
13,307 Views
11 Pages

Old Age Bipolar Disorder—Epidemiology, Aetiology and Treatment

  • Ivan Arnold,
  • Julia Dehning,
  • Anna Grunze and
  • Armand Hausmann

Data regarding older age bipolar disorder (OABD) are sparse. Two major groups are classified as patients with first occurrence of mania in old age, the so called “late onset” patients (LOBD), and the elder patients with a long-standing clinical histo...

  • Article
  • Open Access
41 Citations
3,114 Views
8 Pages

Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI

  • Aydin Rodi Tosu,
  • Muhsin Kalyoncuoglu,
  • Halil İbrahim Biter,
  • Sinem Cakal,
  • Murat Selcuk,
  • Tufan Çinar,
  • Erdal Belen and
  • Mehmet Mustafa Can

Background and objectives: In this study, we aimed to evaluate whether the systemic immune-inflammation index (SII) has a prognostic value for major adverse cardiac events (MACEs), including stroke, re-hospitalization, and short-term all-cause mortal...

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Medicina - ISSN 1648-9144