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Volume 58
Issue 12
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Case Report

Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report

by
Estera Boeriu
1,2,†,
Alexandra Georgiana Boc
1,
Alexandra Borda
2,
Rodica Anamaria Negrean
3,
Bogdan Feciche
4,†,
Amalia Iulia Boeriu
5,
Florin George Horhat
6,*,
Ion Cristian Mot
7,
Ioana Delia Horhat
7,
Madhavi Ravulapalli
8,
Omar Sabuni
9,
Abduljabar Adi
10,
Adnan Anjary
11 and
Smaranda Teodora Arghirescu
1,2
1
Department of Pediatrics, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania
2
Department of Oncology and Haematology, “Louis Turcanu” Emergency Clinical Hospital for Children, Iosif Nemoianu Street 2, 300011 Timisoara, Romania
3
Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
4
Department of Urology, Satu-Mare County Emergency Hospital, Strada Ravensburg 2, 440192 Satu-Mare, Romania
5
Klinikum Landshut, Teaching Hospital of the LMU Munich, Clinic for Anaesthesiology, Intensive Care Medicine and Pain Therapy, Robert-Koch-Strasse, 184034 Landshut, Germany
6
Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
7
Department of Ear-Nose-Throat, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania
8
Bhaskar Medical College, Amdapur Road 156-162, Hyderabad 500075, India
9
Faculty of General Medicine, Altinbas University, Dilmenler Cd., 34217 Istanbul, Turkey
10
Faculty of General Medicine, Baskent University, Fatih Sultan, 06790 Ankara, Turkey
11
Faculty of General Medicine, Yeditepe University, Kayısdagı Cd., 34755 Istanbul, Turkey
 
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*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Medicina 2022, 58(12), 1715; https://doi.org/10.3390/medicina58121715
Submission received: 17 October 2022 / Revised: 19 November 2022 / Accepted: 22 November 2022 / Published: 23 November 2022
(This article belongs to the Special Issue Advances in Cancer Therapy from Research to Clinical Practice—Surgical, Molecular or Systemic Management of Cancer)
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Abstract

Agents of platinum-based chemotherapy, such as cisplatin or carboplatin, are used in the treatment of a wide range of malignancies that affect children, such as brain tumors, osteosarcoma, neuroblastoma, hepatoblastoma, and germ cell tumors (GCTs). The Cyclophosphamide Equivalent Dose (CED) calculator for reproductive risk does not take platinum-based chemotherapy into account, despite the fact that it accounts for the majority of chemotherapy medications that are typically administered for pediatric GCTs. As a result, exposure to platinum-based drugs throughout infancy can have predictable long-term effects such as infertility, as well as other rare encounters such as lipoma formation and lipomatosis. Lipomas are the most prevalent benign soft tissue tumor subtype. They may be either solitary entities or engaged in multiple lipomatosis, which may have a familial origin or be an acquired disorder. Chemotherapy is a possible cause of lipomatosis. Chemotherapy based on cisplatin has been linked to a variety of long-term consequences, including kidney damage, neurotoxicity, and pulmonary toxicity, and may even create secondary cancers. However, lipoma development is known to occur in fewer than 1 in 100 individuals, and only a few examples of multiple cutaneous lipomatosis triggered by this therapy have been documented. Here we present a very rare case of lipomatosis in a pediatric patient with GCT under cisplatin therapy, which might be the third report of this kind affecting children.
Keywords: pediatric oncology; lipomatosis; cisplatin; platinum-based chemotherapy; germ cell tumors pediatric oncology; lipomatosis; cisplatin; platinum-based chemotherapy; germ cell tumors

Share and Cite

MDPI and ACS Style

Boeriu, E.; Boc, A.G.; Borda, A.; Negrean, R.A.; Feciche, B.; Boeriu, A.I.; Horhat, F.G.; Mot, I.C.; Horhat, I.D.; Ravulapalli, M.; et al. Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report. Medicina 2022, 58, 1715. https://doi.org/10.3390/medicina58121715

AMA Style

Boeriu E, Boc AG, Borda A, Negrean RA, Feciche B, Boeriu AI, Horhat FG, Mot IC, Horhat ID, Ravulapalli M, et al. Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report. Medicina. 2022; 58(12):1715. https://doi.org/10.3390/medicina58121715

Chicago/Turabian Style

Boeriu, Estera, Alexandra Georgiana Boc, Alexandra Borda, Rodica Anamaria Negrean, Bogdan Feciche, Amalia Iulia Boeriu, Florin George Horhat, Ion Cristian Mot, Ioana Delia Horhat, Madhavi Ravulapalli, and et al. 2022. "Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report" Medicina 58, no. 12: 1715. https://doi.org/10.3390/medicina58121715

APA Style

Boeriu, E., Boc, A. G., Borda, A., Negrean, R. A., Feciche, B., Boeriu, A. I., Horhat, F. G., Mot, I. C., Horhat, I. D., Ravulapalli, M., Sabuni, O., Adi, A., Anjary, A., & Arghirescu, S. T. (2022). Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report. Medicina, 58(12), 1715. https://doi.org/10.3390/medicina58121715

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