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Article

The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI

by
Eriko Fukuda
1,
Akihiro Hamuro
2,*,
Kohei Kitada
2,
Yasushi Kurihara
2,
Mie Tahara
2,
Takuya Misugi
2,
Akemi Nakano
2,
Mami Tamaue
3,
Sae Shinomiya
4,
Hisako Yoshida
4,
Masayasu Koyama
2 and
Daisuke Tachibana
2
1
Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 5454-8585, Japan
2
Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi, Abeno-ku, Osaka 5454-8585, Japan
3
Women’s Health Care Science, Advanced Care Science Field, Graduate School of Nursing, Osaka Metropolitan University, 1-5-17 Asahimachi, Abeno-ku, Osaka 5454-8585, Japan
4
Department of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi, Abeno-ku, Osaka 5454-8585, Japan
*
Author to whom correspondence should be addressed.
Medicina 2023, 59(10), 1715; https://doi.org/10.3390/medicina59101715
Submission received: 4 September 2023 / Revised: 22 September 2023 / Accepted: 23 September 2023 / Published: 25 September 2023
(This article belongs to the Special Issue Diagnosis, Evaluation, and Management of Diseases during Pregnancy: Part II)
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Abstract

Background and Objectives: Vasa previa (VP) is a significant perinatal complication that can have serious consequences for the fetus/neonate. Velamentous cord insertion (VCI) is a crucial finding in prenatal placental morphology surveillance as it is indicative of comorbid VP. Assisted reproductive technology (ART) has been identified as a risk factor for VCI, so identifying risk factors for VCI in ART could improve VP recognition. This study aims to evaluate the displacement of umbilical cord insertion (CI) from the placental center and to examine the relationship between the modes of conception. Materials and Methods: We conducted a retrospective study at the Obstetrics Department of Osaka Metropolitan University Hospital in Japan between May 2020 and June 2022. The study included a total of 1102 patients who delivered after 22 weeks of gestation. They were divided into three groups: spontaneous pregnancy, conventional in vitro fertilization (cIVF), and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We recorded patient background information, perinatal complications, perinatal outcomes, and a numerical “displacement score”, indicating the degree of separation between umbilical CI and the placental center. Results: The displacement score was significantly higher in the cIVF and IVF/ICSI groups compared with the spontaneous conception group. Additionally, the IVF/ICSI group showed a significantly higher displacement score than the cIVF group. Conclusions: Our study provides the first evidence that the methods of ART can affect the location of umbilical CI on the placental surface. Furthermore, we found that IVF/ICSI may contribute to greater displacement of CI from the placental center.
Keywords: IVF-ET; ICSI; cord insertion (CI); vasa previa; velamentous insertion; feto-fertility IVF-ET; ICSI; cord insertion (CI); vasa previa; velamentous insertion; feto-fertility

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MDPI and ACS Style

Fukuda, E.; Hamuro, A.; Kitada, K.; Kurihara, Y.; Tahara, M.; Misugi, T.; Nakano, A.; Tamaue, M.; Shinomiya, S.; Yoshida, H.; et al. The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI. Medicina 2023, 59, 1715. https://doi.org/10.3390/medicina59101715

AMA Style

Fukuda E, Hamuro A, Kitada K, Kurihara Y, Tahara M, Misugi T, Nakano A, Tamaue M, Shinomiya S, Yoshida H, et al. The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI. Medicina. 2023; 59(10):1715. https://doi.org/10.3390/medicina59101715

Chicago/Turabian Style

Fukuda, Eriko, Akihiro Hamuro, Kohei Kitada, Yasushi Kurihara, Mie Tahara, Takuya Misugi, Akemi Nakano, Mami Tamaue, Sae Shinomiya, Hisako Yoshida, and et al. 2023. "The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI" Medicina 59, no. 10: 1715. https://doi.org/10.3390/medicina59101715

APA Style

Fukuda, E., Hamuro, A., Kitada, K., Kurihara, Y., Tahara, M., Misugi, T., Nakano, A., Tamaue, M., Shinomiya, S., Yoshida, H., Koyama, M., & Tachibana, D. (2023). The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI. Medicina, 59(10), 1715. https://doi.org/10.3390/medicina59101715

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