Mininvasive Cytoreduction Surgery plus HIPEC for Epithelial Ovarian Cancer: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Method
2.2. Study Selection
2.3. Data Extraction
2.4. Quality Assessment
3. Results
3.1. Studies’ Characteristics
3.2. Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
Single Arm Studies | ||||||
---|---|---|---|---|---|---|
Name | Country | Study Design | Selection | Comparability | Exposure | Tot |
Fagotti 2013 [16] | Italy | Retrospective Observational Monocentric study | 2 | 1 | 1 | 4 |
Arjona-Sanchez 2018 [17] | USA | Prospective cohort monocentric study | 0 | 1 | 1 | 2 |
Comparative Studies | ||||||
Fagotti 2014 [8] | Italy | Retrospective cohort study Monocentric | 0 | 3 | 2 | 5 |
Petrillo 2019 [7] | Italy | Prospective cohort study | 2 | 1 | 3 | 6 |
Morton 2020 [18] | USA | Retrospective Cohort Study, monocentric | 2 | 2 | 2 | 6 |
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Single Arm Studies | |||||||||
---|---|---|---|---|---|---|---|---|---|
Name | Country | Study Design | Study Year | FIGO Stage/Population | Surgical Treatment | HIPEC Drugs | Adjuvant Treatment | N of Participants | Mean FUP Months |
Fagotti, 2013 [16] | Italy | Retrospective Observational Monocentric study | 2009–2013 | Isolated platinum sensitive recurrence | SCS | Cisplatin 75 mg/m2; 41.5 °C, 60 min | 6 Carboplatin–Paclitaxel | 10 | 10 |
Arjona-Sanchez, 2018 [17] | USA | Prospective Cohort Monocentric Study | 2016–2018 | IIIC | IDS | Paclitaxel 120 mg/m2; | Neoadjuvant 4 Carboplatin–Paclitaxel; 2 Carboplatin–Paclitaxel | 2 ^ | 7, 5 |
Comparative Studies | |||||||||
Fagotti, 2014 [8] | Italy | Retrospective Cohort Monocentric Study | 2005–2013 | Isolated platinum sensitive recurrence | SCS | Cisplatin 75 mg/m2; 41.5 °C, 60 min | 6 Carboplatin–Paclitaxel | 11 ^ | – |
Petrillo, 2019 [7] | Italy | Prospective Cohort Monocentric Study | 2013–2016 | Platinum sensitive recurrence | SCS | Cisplatin 75 mg/m2; 41.5 °C, 60 min | 6 Carboplatin–Paclitaxel | 9 ^ | 36 |
Morton, 2020 [18] | USA | Retrospective cohort Monocentric Study | 2017–2019 | III, IV | IDS | Cisplatin 80/100 mg/m2; 41–43 °C; 90 min | Neoadjuvant 3/4 Carboplatin–Paclitaxel; 2 Carboplatin–Paclitaxel | 10 ^ | 15, 1 |
Name | CC-0 (%) | RR (%) | 3Y-PFS (%) | 3Y-OS (%) |
---|---|---|---|---|
Fagotti, 2013 [16] | 100 | 100 | 10 | – |
Arjona-Sanchez, 2018 [17] | 100 | 0 | – | – |
Perillo et al., 2019 [7] | 100 | 33.3 | 70 | – |
Morton et al., 2020 [18] | 70 | – | 15 | – |
Name | Early Complication > G3 * (%) | Late Complication > G3 ** (%) | AKI ^ (%) |
---|---|---|---|
Fagotti, 2014 [8] | 0 | 0 | 0 |
Arjona-Sanchez, 2018 [17] | 0 | – | 0 |
Petrillo, 2019 [7] | 11.1 | 0 | 11.1 |
Morton, 2020 [18] | 20 | – | 0 |
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Ronsini, C.; Pasanisi, F.; Greco, P.; Cobellis, L.; De Franciscis, P.; Cianci, S. Mininvasive Cytoreduction Surgery plus HIPEC for Epithelial Ovarian Cancer: A Systematic Review. Medicina 2023, 59, 421. https://doi.org/10.3390/medicina59030421
Ronsini C, Pasanisi F, Greco P, Cobellis L, De Franciscis P, Cianci S. Mininvasive Cytoreduction Surgery plus HIPEC for Epithelial Ovarian Cancer: A Systematic Review. Medicina. 2023; 59(3):421. https://doi.org/10.3390/medicina59030421
Chicago/Turabian StyleRonsini, Carlo, Francesca Pasanisi, Pierfrancesco Greco, Luigi Cobellis, Pasquale De Franciscis, and Stefano Cianci. 2023. "Mininvasive Cytoreduction Surgery plus HIPEC for Epithelial Ovarian Cancer: A Systematic Review" Medicina 59, no. 3: 421. https://doi.org/10.3390/medicina59030421