1. Introduction
Depression and anxiety are leading causes of disability worldwide, contributing to 2.5% of the global burden of disease [
1]. It has been calculated that the global economy loses about USD 1 trillion every year in productivity due to mood disorders [
2]. Furthermore, nearly 800,000 individuals worldwide commit suicide each year [
3].
Jordan is experiencing a considerable surge in depression and anxiety symptoms. Large-scale cross-sectional studies carried out among adolescents and college students demonstrated alarming findings. In one study of college students, the majority reported severe anxiety symptoms (5). Another study recruited more than 2000 adolescents and revealed that 34% experienced moderate to severe depression (6). A further nationwide study (>8000 participants) reported depression in 66% of the study sample (7).
Furthermore, depression and anxiety were highly associated with physical health and chronic diseases. For instance, one recent study demonstrated that half of Coronary Artery Disease Patients suffered from depression [
4], and another report found that 50% of mothers suffered from postpartum depression [
5]. In addition, a school-based survey of adolescents recruiting more than two thousand participants demonstrated a decreased stigma towards depression, and a willingness to seek social or medical advice [
6].
The demand for psychotropic medications is increasing globally [
7]. For example, in the United Kingdom, the total number of antidepressant prescriptions was estimated to be 78 million [
8]; moreover, the cost of sertraline increased by GBP 113 million in 2020 compared to 2019 [
7]. In Jordan, although no published research is indicative of the demand for antidepressants, several studies have highlighted striking evidence of depression prevalence. In one study that included >8000 youth participants, 66% reported a loss of joy and 49% reported a loss of hope [
9] and another study estimated depression to occur a rate of 40% among healthcare workers during the COVID pandemic [
10].
Community pharmacists play an important role in ensuring the patient’s adherence to their treatment. Pharmacists should address the reasons behind nonadherence, such as the patient-related factors including forgetfulness, polypharmacy, and disease misconceptions that affect the patterns of medication use [
11,
12,
13]. Another reason could be social factors, such as cultural matters and religion, where mental illness is perceived as a punishment or as a sign of lacking morality. In these instances, prayers or meditation are often used for the treatment of these diseases [
14,
15]. Yet the major reasons for nonadherence are the delayed efficacy and the side effect profile [
16,
17].
An increase in community pharmacy accessibility, paired with expansion, was intended to provide community pharmacists with the capacity to deliver optimal service for patients receiving psychotropic medications such as antidepressants or anxiolytics [
18]. A 2021 study, which included 459 pharmacists, reported that Jordanian pharmacists felt they had insufficient knowledge and confidence with psychotropic medications [
19].
Several factors are relevant to a pharmacist’s knowledge and confidence when decision-making, such as the quality of education, experiential training, years of experience, and others [
20,
21]
Given the clear importance of this topic, we sought to assess pharmacists using a large-scale study with a focus on technical knowledge regarding psychotropic medications.
Therefore, the current research was aimed at measuring the extent of knowledge of the community pharmacists about psychotropic medications, with the goal of then determining factors associated with higher knowledge scores.
2. Materials and Methods
The present cross-sectional study assessed the knowledge regarding psychotropic medications among community pharmacists in Jordan using a pretested validated, online survey.
2.1. Design
This is a cross-sectional study. The sampling adopted was convenience sampling that covered community pharmacists in different geographical locations in Jordan. An invitation to take the survey was provided to the pharmacist through professional online platforms, as well as invitations provided to the pharmacist in their community pharmacies via personal contact by trained students. Sample size calculation. using the online sample size calculator (
www.raosoft.com accessed on 27 November 2022) with a margin of error of 5%, a confidence level of 95%, and a response distribution of 50% revealed the need for the inclusion of 367 pharmacists, based on the 8000 community pharmacists registered in Jordan.
Participation in the study was available in two ways, online and via a site visit. For the online distribution, an invitation to take part in the survey was uploaded to online platforms, including professional pharmacy social media platforms. The invitation included information about the research and why it was conducted, the approximate time needed to complete the survey, the anonymity of the data collected, that the completion is voluntary, and confidentiality and secure storage of the data, as well as a link to complete the survey using google forms software. The first page of the survey on the google form included the consent to complete the survey. The pharmacists were provided with information about the study and asked whether they agreed to take part by pressing the “I agree” button. Only those who agreed to take part would have access to the survey. To ensure the quality and completeness of the responses and to prevent duplicate entries the google forms software, settings were set to “one response” and “required”. For the distribution via community pharmacist visits, trained students entered community pharmacies in person, explained the study procedure and why it was being conducted, and asked the pharmacist to take part in the study. Only those who agreed and signed a consent form were invited to complete the google form survey. The survey collected data anonymously. The present study protocol was reviewed by the institutional review board at Al Bayt University and ethical approval was obtained to conduct this research (IRB reference number 7/2021/2022).
2.2. Instrument
In the present study, a systematic approach was adopted to develop and pre-test the instrument to achieve the research objectives. The instrument used in the present study was an adapted version of a previously published instrument [
22] with some modifications. We carried out reliability analysis for the instrument and the Cronbach’s alpha result was 0.646, which was considered acceptable (>0.6).
The developed instrument used in the present study has been subject to face and content validity by review by faculty members who were pharmacists and hold a postgraduate degree in pharmacy. After development, the survey was distributed to 10 pharmacists as a pilot distribution to assess the clarity of the items used, usability, and functionality, particularly with online distribution. Comments raised from the faculty members’ review and pilot distribution were addressed and minor changes to the developed survey were made.
The instrument utilised consisted of 26 items, including (1) demographic and practice characteristics, e.g., age, sex, and type of pharmacy; (2) general practice characteristics related to antidepressants, such as perceived knowledge of antidepressants, number of antidepressant prescriptions dispensed, and training received concerning antidepressants; and (3) a battery of factual questions that assess pharmacists’ knowledge about psychotropic medications (antidepressants/anxiolytics), pharmacology and therapeutics, using closed-ended responses, in most of the questions as yes, no, and unsure. A total knowledge score consisting of the sum of correct responses was calculated. Raw data were transformed from the Google form into an Excel sheet, cleaned, and analysed.
2.3. Data Analysis
Standard statistical methodologies were used to assess the knowledge of community pharmacists about antidepressants. The statistical package for social sciences (SPSS) was used to run the analysis. Descriptive statistics, e.g., means and frequencies, were used to summarise the data. Independent sample t-test and one-way ANOVA were used to compare the mean knowledge score by different demographic and practice variables. The variable that had the potential (p < 0.1) to be associated with an increased total knowledge score was entered into a multivariate linear regression analysis to identify variables that had independent, statistically significant predictors associated with an increased total knowledge score. The p-Value was set at p ≤ 0.05.
4. Discussion
This study reported that community pharmacists have a poor knowledge regarding psychotropic medications. Pharmacists who reported higher knowledge were more experienced, reported studying the topic in the pharmacy school, held a Doctor of Pharmacy (Pharm D) degree, and reported a higher perceived knowledge.
Pharmacists’ knowledge is a key factor for effective patient engagement, which leads to success in the therapeutic plan, especially in chronic diseases [
23,
24]. For example, a longitudinal study demonstrated that the effect of the pharmacist telemonitoring of antidepressants showed a significant and positive effect on patients’ feedback, knowledge, experience, and medication beliefs [
25].
Our findings are consistent with the previous literature demonstrating poor knowledge of psychotropic medications. In one study, about 40% of pharmacists admitted to not being involved in antidepressant counselling, and 36% of pharmacists admitted to discussing the antidepressants’ side effects with only a few patients [
26]. Furthermore, in one study, less than 20% of patients initiated on antidepressants were educated about the possible side effects of antidepressants, and only 34% of the pharmacists mentioned the need to continue the antidepressant for at least six months [
27].
Although this poor knowledge is reflected in poor patient-related outcomes and satisfaction, nevertheless, no published studies coming from Jordan have related the pharmacist’s role to patient satisfaction.
In our study, pharmacists with higher experience and the Pharm D participants achieved better knowledge compared to the BSc programme graduates. Our findings support previous studies; the pharmacists’ years of experience were reflected in their knowledge and confidence [
28]. Furthermore, this finding can be explained by the fact that the years of experience are related to the accumulated knowledge acquired through continuous medical education programmes, interaction with other healthcare professionals, and the number of prescriptions dispensed [
29,
30].
The findings of this study revealed that Pharm D participants achieved superior knowledge. Our findings support previous studies demonstrating that Pharm D graduates are more knowledgeable compared to bachelor’s degree graduates [
31]. The Pharm D programme comprises more detailed theoretical courses and one-year experiential training courses applied in hospitals and community pharmacies. According to the literature, the interventions of clinical pharmacists, including drug monitoring, patient education, and drug management have a positive effect on mental health problems [
32].
The study has several strengths, such as the objective measurement of the actual knowledge of the most commonly used psychotropic agents, the sample size, and the diversity of the participants recruited. However, the online data collection approach could have led to inaccurate data collection compared to the site visit. Additionally, the pharmacist’s knowledge was not reflected in their role in patient adherence and improvement. No data are available about how much pharmacists influenced adherence to psychotropic agents. Moreover, data are missing about the pharmacist’s role in the management of mental health outcomes in Jordan.