Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Data Collection
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group H (n = 35,452) | Group C (n = 35,452) | p Value | |
---|---|---|---|
Age (years) | 79.50 ± 5.90 | 79.50 ± 5.90 | 0.999 |
Sex | |||
M | 13,500 (38.1) | 13,500 (38.1) | 1.000 |
F | 21,952 (61.9) | 21,952 (61.9) | |
Income | |||
Low | 4285 (12.1) | 4285 (12.1) | 1.000 |
Middle | 16,316 (46.0) | 16,316 (46.0) | |
High | 14,851 (41.9) | 14,851 (41.9) | |
Comorbidities | |||
Myocardial infarct | 2470 (7.0) | 2224 (6.3) | |
Cerebrovascular disease | 16,545 (46.7) | 15,005 (42.3) | <0.001 |
Rheumatic or connective disease (autoimmune disease) | 8163 (23.0) | 6432 (18.1) | <0.001 |
Diabetes mellitus | 16,693 (47.1) | 14,200 (40.1) | <0.001 |
Moderate or severe renal failure (chronic renal disease) | 594 (1.7) | 509 (1.4) | 0.010 |
Otitis media | 8887 (25.1) | 6965 (19.6) | <0.001 |
Hypertension | 28,688 (80.9) | 26,509 (74.8) | <0.001 |
SSNHL | 2325 (6.6) | 2143 (6.0) | 0.005 |
Group | Average (Year) | SE | 95% CI | |
---|---|---|---|---|
Lower | Upper | |||
Group H | 8.703 | 0.059 | 8.588 | 8.818 |
Group C | 7.773 | 0.078 | 7.620 | 7.927 |
Overall | 8.257 | 0.049 | 8.161 | 8.353 |
Group H | Group C | IRR | p Value | |||||||
---|---|---|---|---|---|---|---|---|---|---|
n | SSNHL | Person-Years | Rate * | n | SSHL | Person-Years | Rate * | |||
overall | 35,452 | 2325 | 2,715,540 | 8.6 | 35,452 | 2143 | 2,415,324 | 8.9 | 1.085 (1.023–1.151) | 0.006 |
Year of follow-up | ||||||||||
<1 | 35,452 | 11 | 35,452 | 3.1 | 35,452 | 75 | 35,452 | 21.2 | 0.147 (0.078–0.276) | 0.002 |
1–5 | 35,390 | 345 | 689,031 | 5.0 | 34,326 | 523 | 630,980 | 8.3 | 0.660 (0.576–0.756) | 0.000 |
5< | 32,582 | 1969 | 1,991,057 | 9.8 | 28,875 | 1545 | 1,748,892 | 8.8 | 1.274 (1.192–1.362) | 0.000 |
Variable | Adjusted HR | 95% CI | p Value | |
---|---|---|---|---|
Low | high | |||
Main model | 0.890 | 0.839 | 0.944 | <0.001 |
Full model | 0.894 | 0.843 | 0.949 | <0.001 |
Additional covariates | ||||
Main model + Myocardial infarct | 0.890 | 0.839 | 0.944 | <0.001 |
Main model + Cerebrovascular disease | 0.889 | 0.838 | 0.943 | <0.001 |
Main model + Rheumatic or connective disease (autoimmune disease) | 0.891 | 0.840 | 0.945 | <0.001 |
Main model + diabetes mellitus | 0.891 | 0.841 | 0.945 | <0.001 |
Main model + Moderate or severe renal failure (chronic renal disease | 0.889 | 0.839 | 0.943 | <0.001 |
Main model + Otitis media | 0.894 | 0.843 | 0.948 | <0.001 |
Main model + hypertension | 0.890 | 0.840 | 0.944 | <0.001 |
Subgroup effects * | ||||
Sex | ||||
M | 0.933 | 0.837 | 1.040 | 0.210 |
F | 0.880 | 0.820 | 0.944 | <.001 |
Age | ||||
60–70 | 0.289 | 0.360 | 2.307 | 0.241 |
70–80 | 0.919 | 0.850 | 0.994 | 0.034 |
80- | 0.862 | 0.788 | 0.944 | 0.001 |
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Son, H.J.; Choi, E.-J.; Jeong, U.; Choi, Y.J. Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea. Medicina 2023, 59, 808. https://doi.org/10.3390/medicina59040808
Son HJ, Choi E-J, Jeong U, Choi YJ. Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea. Medicina. 2023; 59(4):808. https://doi.org/10.3390/medicina59040808
Chicago/Turabian StyleSon, Hyo Jung, Eun-Ji Choi, Ukjin Jeong, and Yoon Ji Choi. 2023. "Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea" Medicina 59, no. 4: 808. https://doi.org/10.3390/medicina59040808