Association between Hyperuricemia and Hearing Impairment: Results from the Korean National Health and Nutrition Examination Survey
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Data Collection
2.3. Audiometric Measurement
2.4. Statistical Analyses
3. Results
3.1. Demographic and Clinical Characteristics of the Study Population
3.2. Association between Hyperuricemia/Gout and Hearing Impairment
3.3. Clinical Characteristics According to Presence of Hyperuricemia
3.4. Factors Associated with Hearing Impairment
3.5. Factors Associated with Hearing Impairment According to Frequency
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Category | N (Weighted %) |
---|---|---|
Age, years | 56.8 ± 0.3 | |
Sex | Male | 8,691,336 (48.3) |
Female | 9,299,389 (51.7) | |
Education level | Elementary school | 2,995,942 (16.7) |
Middle school | 1,981,792 (11.0) | |
High school | 6,338,706 (35.2) | |
University | 6,674,285 (37.1) | |
Marital status | Married | 17,155,817 (95.4) |
Unmarried | 834,908 (4.6) | |
Current smoking | Never smoking | 10,145,665 (56.4) |
Ex-smoker | 4,761,340 (26.5) | |
Current smoker | 3,083,720 (17.1) | |
Heavy alcohol use * | No | 13,951,063 (77.6) |
Yes | 4,039,662 (22.5) | |
Occupational noise exposure † | No | 15,044,870 (83.6) |
Yes | 2,945,855 (16.4) | |
Body mass index (kg/m2) | BMI < 25 | 10,899,796 (60.6) |
BMI ≥ 25 | 7,090,929 (39.4) | |
Diabetes | Normal | 6,240,013 (34.7) |
Pre-diabetes | 8,421,703 (46.8) | |
Diabetes | 3,329,009 (18.5) | |
Dyslipidemia | No | 12,349,295 (68.6) |
Yes | 5,641,430 (31.4) | |
Hypertension | Normal | 6,293,940 (35.0) |
Pre-hypertension | 4,918,288 (27.3) | |
Hypertension | 6,778,497 (37.7) | |
Gout | No | 17,534,556 (97.5) |
Yes | 456,169 (2.5) | |
Systolic blood pressure, mmHg | 121.2 ± 0.4 | |
Diastolic blood pressure, mmHg | 77.2 ± 0.2 | |
Total cholesterol, mg/dL | 193.5 ± 0.8 | |
High-density cholesterol, mg/dL | 50.9 ± 0.3 | |
Triglyceride, mg/dL | 141.9 ± 2.5 | |
Low-density cholesterol, mg/dL | 114.3 ± 0.8 | |
Aspartate transaminase, IU/L | 25.2 ± 0.2 | |
Alanine transaminase, IU/L | 23.9 ± 0.3 | |
Uric acid, mg/dL | 5.09 ± 0.02 | |
Hyperuricemia ‡ | No | 15,813,858 (87.9) |
Yes | 2,176,886 (12.1) | |
BUN, mg/dL | 15.6 ± 0.1 | |
Serum creatinine, mg/dL | 0.82 ± 0.00 | |
eGFR, mL/min/1.73 m2 | eGFR < 60 | 722,575 (4.0) |
eGFR ≥ 60 | 17,268,150 (96.0) |
Total | Sex | Age | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Variable | Male | Female | Age < 60 Years | Age ≥ 60 Years | ||||||
Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | |
Gout | 0.83 (0.44, 1.55) | 0.554 | 0.69 (0.35, 1.35) | 0.282 | 0.94 (0.12, 7.43) | 0.952 | 0.68 (0.16, 2.97) | 0.611 | 0.83 (0.4, 1.73) | 0.618 |
Hyperuricemia † | 1.55 (1.18, 2.03) | 0.002 | 1.03 (0.72, 1.49) | 0.856 | 2.71 (1.8, 4.09) | <0.0001 | 1.34 (0.68, 2.64) | 0.405 | 1.7 (1.22, 2.38) | 0.002 |
Male (n = 2118, Weighted n = 8,691,336) | Female (n = 2739, Weighted n = 9,229,389) | ||||||
---|---|---|---|---|---|---|---|
Variable | Category | Normal UA UA < 7 mg/dL n = 1759 Weighted n = 7,187,399 | Hyperuricemia UA ≥ 7 mg/dL n = 359 Weighted n = 1,503,936 | p-Value | Normal UA UA < 6 mg/dL (n = 2524, Weighted n = 8,626,459) | Hyperuricemia UA ≥ 6 mg/dL (n = 215, Weighted n = 672,930) | p-Value |
Age, years | 56.6 ± 0.4 | 54.2 ± 0.7 | <0.001 | 56.93 ± 0.37 | 62.92 ± 0.97 | <0.001 | |
Education level | Elementary school | 800,625 (11.1) | 155,701 (10.4) | 0.935 | 1,767,698 (20.5) | 271,918 (40.4) | <0.001 |
Middle school | 757,357 (10.5) | 144,503 (9.6) | 991,327 (11.5) | 88,606 (13.2) | |||
High school | 2,473,190 (34.4) | 514,109 (34.2) | 3,188,732 (37.0) | 162,676 (24.2) | |||
University | 3,156,227 (43.9) | 689,624 (45.9) | 2,678,703 (31.1) | 149,731 (22.3) | |||
Current smoking | Never smoking | 1,370,952 (19.1) | 257,091 (17.1) | 0.454 | 7,933,117 (92.0) | 584,506 (86.8) | 0.093 |
Ex-smoker | 3,481,894 (48.4) | 798,304 (53.1) | 419,409 (4.8) | 61,733 (9.2) | |||
Current smoker | 2,334,554 (32.5) | 448,541 (29.8) | 273,934 (3.2) | 26,691 (4.0) | |||
Heavy alcohol use * | No | 4,626,014 (64.4) | 933,307 (62.1) | 0.508 | 7,799,737 (90.4) | 592,005 (88.0) | 0.343 |
Yes | 2,561,386 (35.6) | 570,629 (37.9) | 826,722 (9.6) | 80,925 (12.0) | |||
Occupational noise exposure † | No | 5,568,403 (77.5) | 1,235,270 (82.1) | 0.066 | 7,644,186 (88.6) | 597,013 (88.7) | 0.970 |
Yes | 1,618,997 (22.5) | 268,667 (17.9) | 982,274 (11.4) | 75,917 (11.3) | |||
Body mass index (kg/m2) | BMI < 25 | 4,036,396 (56.2) | 625,657 (41.6) | <0.001 | 5,943,042 (68.9) | 294,702 (43.8) | <0.001 |
BMI ≥ 25 | 3,151,004 (43.8) | 878,279 (58.4) | 2,683,418 (31.1) | 378,228 (56.2) | |||
Diabetes | Normal | 2,213,239 (30.8) | 393,456 (26.1) | 0.046 | 3,515,586 (40.7) | 117,732 (17.5) | <0.001 |
Pre-diabetes | 3,344,054 (46.5) | 838,892 (55.8) | 3,860,898 (44.8) | 377,859 (56.2) | |||
Diabetes | 1,630,107 (22.7) | 271,589 (18.1) | 1,249,975 (14.5) | 177,339 (26.3) | |||
Dyslipidemia | No | 5,120,649 (71.2) | 1,006,763 (66.9) | 0.219 | 5,801,461 (67.3) | 420,422 (62.5) | 0.162 |
Yes | 2,066,751 (28.8) | 497,173 (33.1) | 2,824,998 (32.7) | 252,508 (37.5) | |||
Hypertension | Normal | 2,046,641 (28.5) | 359,640 (23.9) | 0.176 | 3,727,327 (43.2) | 160,332 (22.8) | <0.001 |
Pre-hypertension | 2,205,245 (30.7) | 438,879 (29.2) | 2,141,151 (24.8) | 133,014 (19.8) | |||
Hypertension | 2,935,514 (40.8) | 705,417 (46.9) | 2,757,981 (32.0) | 379,585 (56.4) | |||
Systolic blood pressure, mmHg | 121.8 ± 0.5 | 123.6 ± 1.0 | 0.092 | 119.77 ± 0.53 | 126.88 ±1.25 | <0.001 | |
Diastolic blood pressure, mmHg | 78.9 ± 0.3 | 80.9 ± 0.8 | 0.012 | 75.3 ± 0.24 | 74.99 ±0.77 | 0.694 | |
Total cholesterol, mg/dL | 188.02 ± 1.3 | 199.07 ± 2.84 | 0.001 | 197.1 ± 1.1 | 194.9 ± 3.1 | 0.553 | |
HDL, mg/dL | 46.9 ± 0.3 | 44.9 ± 0.6 | 0.005 | 55.39 ± 0.33 | 48.3 ± 0.8 | <0.001 | |
Triglyceride, mg/dL | 159.7 ± 4.5 | 210.4 ± 10.7 | <0.001 | 114.2 ± 2.0 | 153.0 ± 6.7 | <0.001 | |
LDL, mg/dL | 109.1 ± 1.4 | 112.1 ± 3.1 | 0.412 | 118.8 ± 0.9 | 116.1 ± 3.2 | 0.422 | |
Aspartate transaminase, IU/L | 26.3 ± 0.4 | 30.9 ± 1.4 | 0.001 | 23.2 ± 0.2 | 25.97 ± 1 | 0.011 | |
Alanine transaminase, IU/L | 27.3 ± 0.5 | 33.5 ± 1.4 | <0.001 | 19.5 ± 0.3 | 23.39 ± 1.68 | 0.026 | |
Uric acid, mg/dL | 5.40 ± 0.03 | 7.77 ± 0.04 | <0.001 | 4.24 ± 0.02 | 6.68 ± 0.05 | <0.001 | |
BUN, mg/dL | 15.9 ± 0.1 | 16.6 ± 0.4 | 0.081 | 14.9 ± 0.1 | 18.6 ± 0.5 | <0.001 | |
Creatinine, mg/dL | 0.93 ± 0 | 1.03 ± 0.02 | <0.001 | 0.68 ± 0 | 0.89 ± 0.03 | <0.001 | |
eGFR, mL/min/1.73 m2 | eGFR ≥60 | 6,957,257 (96.8) | 1,341,368 (89.2) | <0.001 | 8,453,185 (98.0) | 516,339 (76.7) | <0.001 |
eGFR <60 | 230,142 (3.2) | 162,568 (10.8) | 173,274 (2.01) | 156,591 (23.2) |
Variable | Category | Total | Male | Female | Age < 60 Years | Age ≥ 60 Years | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | ||
Age, years | 1.13 (1.11, 1.14) | <0.001 | 1.12 (1.1, 1.14) | <0.001 | 1.14 (1.12, 1.16) | <0.001 | 1.12 (1.08, 1.17) | <0.001 | 1.14 (1.12, 1.17) | <0.001 | |
Sex (reference: male) | Female | 0.70 (0.59, 0.83) | <0.001 | 0.44 (0.28, 0.71) | <0.001 | 0.67 (0.55, 0.82) | <0.001 | ||||
Education level (reference: elementary) | <0.001 | <0.001 | <0.001 | 0.001 | <0.001 | ||||||
Middle school | 0.44 (0.34, 0.57) | <0.001 | 0.72 (0.47, 1.10) | 0.133 | 0.22 (0.15, 0.34) | <0.001 | 1.30 (0.51, 3.34) | 0.587 | 0.53 (0.39, 0.7) | <0.001 | |
High school | 0.25 (0.19, 0.33) | <0.001 | 0.38 (0.25, 0.56) | <0.001 | 0.14 (0.10, 0.19) | <0.001 | 0.91 (0.33, 2.48) | 0.856 | 0.50 (0.38, 0.66) | <0.001 | |
University | 0.09 (0.07, 0.13) | <0.001 | 0.12 (0.08, 0.18) | <0.001 | 0.05 (0.02, 0.09) | <0.001 | 0.25 (0.09, 0.67) | 0.006 | 0.41 (0.31, 0.56) | <0.001 | |
Current smoking (reference: never smoking) | 0.059 | 0.203 | 0.001 | 0.004 | 0.235 | ||||||
Ex-smoker | 1.27 (1.04, 1.54) | 0.020 | 1.08 (0.79, 1.47) | 0.618 | 0.23 (0.09, 0.58) | 0.002 | 2.07 (1.15, 3.74) | 0.016 | 1.17 (0.92, 1.49) | 0.198 | |
Current smoker | 1.00 (0.76, 1.31) | 0.976 | 0.81 (0.56, 1.18) | 0.279 | 0.51 (0.23, 1.12) | 0.097 | 1.93 (1.06, 3.51) | 0.032 | 1.30 (0.89, 1.89) | 0.179 | |
Heavy alcohol use * | Yes | 0.78 (0.60,1.00) | 0.054 | 0.80 (0.60, 1.07) | 0.134 | 0.19 (0.09, 0.42) | <0.001 | 1.27 (0.8, 2.03) | 0.312 | 0.91 (0.68, 1.22) | 0.536 |
Occupational noise exposure † | Yes | 1.69 (1.35, 2.17) | <0.001 | 1.85 (1.41, 2.50) | <0.001 | 1.20 (0.51, 1.82) | 0.372 | 2.70 (1.69, 4.35) | <0.001 | 1.33 (1.02, 1.75) | 0.039 |
Body mass index (kg/m2) | BMI ≥ 25 | 0.95 (0.78, 1.15) | 0.589 | 0.87 (0.66, 1.14) | 0.313 | 0.94 (0.72, 1.22) | 0.652 | 1.25 (0.77, 2.02) | 0.373 | 0.83 (0.65, 1.05) | 0.115 |
Diabetes | Yes | 2.38 (1.83, 3.09) | <0.001 | 1.70 (1.18, 2.46) | 0.005 | 3.28 (2.26, 4.77) | <0.001 | 1.45 (0.74, 2.85) | 0.285 | 1.17 (0.85, 1.62) | 0.326 |
Dyslipidemia | Yes | 1.42 (1.17, 1.72) | <0.001 | 1.29 (0.98, 1.70) | 0.076 | 1.64 (1.26, 2.12) | <0.001 | 1.59 (1.03, 2.46) | 0.039 | 0.87 (0.70, 1.08) | 0.196 |
Hypertension | Yes | 2.56 (2.00, 3.28) | <0.001 | 1.75 (1.29, 2.37) | <0.001 | 3.51 (2.40, 5.12) | <0.001 | 1.58 (0.91, 2.72) | 0.103 | 1.29 (0.96, 1.72) | 0.093 |
eGFR, mL/min/1.73 m2 | eGFR < 60 | 4.00 (2.78, 5.88) | <0.001 | 3.45 (2.08, 5.88) | <0.001 | 4.76 (2.86, 8.33) | <0.001 | 3.13 (0.66, 14.29) | 0.150 | 1.89 (1.25, 2.86) | 0.003 |
Hyperuricemia ‡ | Yes | 1.55 (1.18, 2.03) | 0.002 | 1.03 (0.72, 1.49) | 0.856 | 2.71 (1.80, 4.09) | <0.001 | 1.34 (0.68, 2.64) | 0.405 | 1.70 (1.22, 2.38) | 0.002 |
Variable | Category | Total | Male | Female | Age < 60 Years | Age ≥ 60 Years | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | Weighted OR (95% CI) | p-Value | ||
Age, years | 1.12 (1.1, 1.14) | <0.001 | 1.12 (1.1, 1.14) | <0.001 | 1.11 (1.09, 1.14) | <0.001 | |||||
Sex (reference: male) | Female | 0.46 (0.34, 0.64) | <0.001 | 0.42 (0.26, 0.69) | <0.001 | 0.39 (0.29, 0.54) | <0.001 | ||||
<0.001 | 0.002 | <0.001 | <0.001 | <0.001 | |||||||
Education level (reference: elementary) | Middle school | 0.72 (0.54, 0.95) | 0.020 | 1.28 (0.82, 2.01) | 0.280 | 0.41 (0.26, 0.64) | <0.001 | 1.22 (0.46, 3.21) | 0.690 | 0.50 (0.37, 0.67) | <0.001 |
High school | 0.85 (0.64, 1.15) | 0.300 | 1.23 (0.79, 1.92) | 0.353 | 0.62 (0.41, 0.94) | 0.027 | 0.91 (0.32, 2.62) | 0.862 | 0.44 (0.33, 0.59) | <0.001 | |
University | 0.43 (0.3, 0.63) | <0.001 | 0.61 (0.38, 0.98) | 0.040 | 0.33 (0.16, 0.68) | 0.003 | 0.24 (0.08, 0.7) | 0.010 | 0.33 (0.23, 0.47) | <0.001 | |
0.534 | 0.514 | 0.247 | 0.648 | 0.247 | |||||||
Current smoking (reference: never smoking) | Ex-smoker | 0.9 (0.65, 1.23) | 0.494 | 0.97 (0.67, 1.41) | 0.879 | 0.42 (0.14, 1.2) | 0.105 | 1.15 (0.64, 2.07) | 0.625 | 0.76 (0.54, 1.07) | 0.117 |
Current smoker | 1.11 (0.72, 1.7) | 0.629 | 1.24 (0.76, 2.04) | 0.384 | 0.8 (0.32, 2.02) | 0.644 | 0.88 (0.46, 1.69) | 0.706 | 0.75 (0.47, 1.2) | 0.234 | |
Heavy alcohol use * | Yes | 0.91 (0.68, 1.21) | 0.511 | 0.95 (0.69, 1.32) | 0.773 | 0.52 (0.23, 1.2) | 0.129 | 0.93 (0.59, 1.48) | 0.772 | 0.72 (0.52, 1) | 0.054 |
Occupational noise exposure † | Yes | 1.65 (1.25, 2.22) | <0.001 | 1.91 (1.37, 2.69) | <0.001 | 1.25 (0.79, 1.97) | 0.344 | 1.89 (1.18, 3.02) | 0.009 | 1.18 (0.88, 1.59) | 0.265 |
Body mass index (kg/m2) | BMI ≥ 25 | 0.91 (0.72, 1.15) | 0.429 | 1.07 (0.78, 1.47) | 0.666 | 0.72 (0.51, 1.00) | 0.054 | 1.00 (0.60, 1.66) | 0.988 | 0.74 (0.58, 0.93) | 0.012 |
Diabetes | Yes | 0.96 (0.75, 1.21) | 0.730 | 0.77 (0.56, 1.06) | 0.116 | 1.13 (0.81, 1.57) | 0.489 | 0.72 (0.38, 1.34) | 0.300 | 1.13 (0.88, 1.45) | 0.344 |
Dyslipidemia | Yes | 1.04 (0.83, 1.3) | 0.735 | 1.20 (0.86, 1.66) | 0.288 | 0.9 (0.65, 1.23) | 0.504 | 1.47 (0.94, 2.29) | 0.090 | 0.89 (0.71, 1.12) | 0.331 |
Hypertension | Yes | 1.03 (0.8, 1.32) | 0.836 | 1.09 (0.8, 1.47) | 0.581 | 0.89 (0.62, 1.29) | 0.554 | 1.19 (0.73, 1.94) | 0.482 | 1.29 (0.99, 1.67) | 0.056 |
eGFR, mL/min/1.73 m2 | eGFR ≥ 60 | 1.06 (0.68, 1.67) | 0.786 | 1.10 (0.60, 2.00) | 0.768 | 1.00 (0.59, 1.69) | 0.992 | 2.32 (0.56, 10.00) | 0.253 | 1.37 (0.89, 2.08) | 0.150 |
Hyperuricemia ‡ | Yes | 1.41 (1.03, 1.92) | 0.031 | 1.34 (0.88, 2.06) | 0.176 | 1.59 (1.02, 2.48) | 0.041 | 0.99 (0.52, 1.89) | 0.970 | 1.45 (1.05, 1.99) | 0.023 |
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Jeong, H.; Chang, Y.-S.; Jeon, C.-H. Association between Hyperuricemia and Hearing Impairment: Results from the Korean National Health and Nutrition Examination Survey. Medicina 2023, 59, 1273. https://doi.org/10.3390/medicina59071273
Jeong H, Chang Y-S, Jeon C-H. Association between Hyperuricemia and Hearing Impairment: Results from the Korean National Health and Nutrition Examination Survey. Medicina. 2023; 59(7):1273. https://doi.org/10.3390/medicina59071273
Chicago/Turabian StyleJeong, Hyemin, Young-Soo Chang, and Chan-Hong Jeon. 2023. "Association between Hyperuricemia and Hearing Impairment: Results from the Korean National Health and Nutrition Examination Survey" Medicina 59, no. 7: 1273. https://doi.org/10.3390/medicina59071273