Relationship between XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 Polymorphisms and the Susceptibility to Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Identification of Articles
2.3. Selection Criteria
2.4. Data Summary
2.5. Quality Evaluation
2.6. Statistical Analyses
3. Results
3.1. Study Selection
3.2. Characteristics of the Articles
3.3. Pooled Analysis
3.4. Subgroup Analysis
3.5. Meta-Regression Analysis
3.6. Sensitivity Analysis
3.7. TSA
3.8. Publication Bias
3.9. STRING Results
4. Discussion
5. Conclusions
Supplementary Materials
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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The Study, Publication Year | Country | Ethnicity | Number of Cases/Controls | Control Source | Polymorphism: HWE p-Value in Controls | Genotyping Method | Tumor Site | Quality Score |
---|---|---|---|---|---|---|---|---|
Abbasi, 2009 [34] | Germany | Caucasian | 248/647 | PB | rs17655: <0.0001 rs1047768: 0.7616 rs1800975: 0.7373 | PCR-RFLP | LC | 8 |
An, 2007 [35] | USA | Caucasian | 829/854 | HB | rs1800975: 0.0010 rs17655: 0.4245 | PCR | HNC | 8 |
Avci, 2018 [25] | Turkey | Caucasian | 111/148 | PB | rs17655: 0.1716 | PCR | OC | 9 |
Bau, 2007 [36] | Taiwan | Asian | 154/105 | PB | rs1800975: 0.8954 | PCR | OC | 8 |
Cui, 2006 [37] | USA | Mixed | 443/911 | PB | rs17655: <0.0001 | PCR | NPC | 9 |
Hall, 2007 [26] | France | Caucasian | 597/770 | HB | rs1800975: 0.2248 | PCR | HNC | 8 |
Jelonek, 2010 [38] | Poland | Caucasians | 66/113 | PB | rs1800975: 0.0551 | PCR | HNC | 6 |
Li, 2014 [24] | China | Asian | 211/210 | HB | rs17655: 0.0003 rs1047768: 0.3326 rs2276465: 0.0023 rs2276466: 0.0970 rs6498486: 0.1517 rs4150441: 0.0034 rs1800975: <0.0001 | PCR | LC | 7 |
Lu, 2014 [27] | China | Asian | 176/176 | HB | rs17655: 0.0007 rs2276465: 0.0071 rs6498486: 0.1479 rs4150441: 0.0127 rs1800975: <0.0001 | PCR | LC | 7 |
Ma, 2012 [39] | USA | Mixed | 1059/1059 | PB | rs17655: 0.1749 rs1047768: 0.6694 rs2094258: 0.0920 rs4771436: 0.9424 | PCR-RFLP | HNC | 9 |
Nigam, 2019 [40] | India | Asian | 67/288 | PB | rs17655: 0.7511 | PCR-RFLP | OC | 8 |
Sugimura, 2006 [41] | Japan | Asian | 122/241 | HB | rs17655: <0.0001 rs1800975: 0.0496 | PCR | OC | 7 |
Sun, 2015 [42] | China | Asian | 271/271 | HB | rs2094258: 0.8255 | PCR-RFLP | LC | 8 |
Wen, 2006 [43] | China | Asian | 175/525 | HB | rs17655: 0.0026 | PCR-RFLP | NPC | 9 |
Xue, 2013 [44] | China | Asian | 142/275 | HB | rs751402: 0.3033 rs6498486: 0.4273 | PCR-RFLP | OC | 8 |
Yu, 2012 [48] | USA | Mixed | 1040/1046 | HB | rs2276466: 0.0636 | PCR-RFLP | HNC | 8 |
Yuan, 2012 [45] | China | Asian | 394/884 | HB | rs17655: <0.0001 | PCR | HNC | 8 |
Zavras, 2012 [46] | Taiwan | Asian | 239/336 | HB | rs751402: 0.3984 | TaqMan and PCR | OC | 6 |
Zhu, 2018 [47] | China | Asian | 199/190 | HB | rs17655: 0.6655 rs1047768: 0.3839 rs4771436: 0.5694 | PCR | LC | 8 |
Polymorphism (N) | Genetic Model | OR | 95%CI | Z-Value | p-Value | I2 | Pheterogeneity | |
---|---|---|---|---|---|---|---|---|
Min. | Max. | |||||||
rs17655 (12) | C vs. G | 0.95 | 0.86 | 1.05 | 1.03 | 0.30 | 56% | 0.009 |
CC vs. GG | 0.86 | 0.75 | 1.00 | 1.98 | 0.05 | 34% | 0.12 | |
GC vs. GG | 1.26 | 0.94 | 1.71 | 1.53 | 0.13 | 85% | <0.00001 | |
CC + GC vs. GG | 1.47 | 0.98 | 2.19 | 1.88 | 0.06 | 93% | <0.00001 | |
CC vs. GG + GC | 0.89 | 0.81 | 0.99 | 2.14 | 0.03 | 31% | 0.14 | |
rs751402 (2) | T vs. C | 1.28 | 1.05 | 1.57 | 2.38 | 0.02 | 0% | 0.55 |
TT vs. CC | 1.74 | 1.10 | 2.74 | 2.39 | 0.02 | 0% | 0.75 | |
CT vs. CC | 0.65 | 0.48 | 0.89 | 2.65 | 0.008 | 5% | 0.31 | |
TT + CT vs. CC | 2.22 | 1.04 | 4.74 | 2.07 | 0.04 | 87% | 0.005 | |
TT vs. CC + CT | 2.48 | 0.78 | 7.93 | 1.53 | 0.12 | 85% | 0.01 | |
rs1047768 (4) | T vs. C | 0.92 | 0.74 | 1.13 | 0.81 | 0.42 | 72% | 0.01 |
TT vs. CC | 0.91 | 0.64 | 1.31 | 0.50 | 0.62 | 60% | 0.06 | |
CT vs. CC | 1.05 | 0.90 | 1.22 | 0.66 | 0.51 | 0% | 0.96 | |
TT + CT vs. CC | 1.06 | 0.92 | 1.22 | 0.74 | 0.46 | 0% | 0.96 | |
TT vs. CC + CT | 1.03 | 0.88 | 1.21 | 0.37 | 0.71 | 0% | 0.99 | |
rs4771436 (2) | G vs. T | 1.02 | 0.89 | 1.16 | 0.25 | 0.81 | 0% | 0.68 |
GG vs. TT | 1.03 | 0.73 | 1.44 | 0.15 | 0.88 | 0% | 0.61 | |
TG vs. TT | 1.02 | 0.86 | 1.20 | 0.23 | 0.81 | 0% | 0.92 | |
GG + TG vs. TT | 3.08 | 0.33 | 28.49 | 0.99 | 0.32 | 98% | <0.00001 | |
GG vs. TT + TG | 1.02 | 0.73 | 1.42 | 0.11 | 0.91 | 0% | 0.62 | |
rs2094258 (2) | A vs. G | 1.05 | 0.92 | 1.20 | 0.71 | 0.48 | 16% | 0.28 |
AA vs. GG | 1.09 | 0.75 | 1.57 | 0.44 | 0.66 | 33% | 0.22 | |
GA vs. GG | 1.06 | 0.89 | 1.25 | 0.65 | 0.51 | 0% | 0.64 | |
AA + GA vs. GG | 1.06 | 0.9 | 1.24 | 0.69 | 0.49 | 0% | 0.42 | |
AA vs. GG + GA | 1.06 | 0.74 | 1.53 | 0.33 | 0.74 | 22% | 0.26 | |
rs6498486 (3) | C vs. A | 1.16 | 0.96 | 1.41 | 1.56 | 0.12 | 0% | 0.93 |
CC vs. AA | 1.36 | 0.89 | 2.09 | 1.41 | 0.16 | 0% | 0.96 | |
AC vs. AA | 1.13 | 0.87 | 1.46 | 0.92 | 0.36 | 0% | 0.99 | |
CC + AC vs. AA | 1.17 | 0.92 | 1.50 | 1.28 | 0.20 | 0% | 0.97 | |
CC vs. AA + AC | 1.29 | 0.86 | 1.95 | 1.22 | 0.22 | 0% | 0.96 | |
rs2276465 (2) | C vs. A | 1.00 | 0.67 | 1.47 | 0.02 | 0.98 | 71% | 0.07 |
CC vs. AA | 1.39 | 0.94 | 2.06 | 1.64 | 0.10 | 0% | 0.97 | |
AC vs. AA | 1.16 | 0.85 | 1.59 | 0.93 | 0.35 | 0% | 0.96 | |
CC vs. AC + AA | 0.74 | 0.28 | 1.96 | 0.60 | 0.55 | 92% | 0.0003 | |
CC vs. AA + AC | 0.93 | 0.48 | 1.80 | 0.22 | 0.83 | 69% | 0.07 | |
rs2276466 (2) | G vs. C | 0.96 | 0.85 | 1.09 | 0.58 | 0.56 | 0% | 0.39 |
GG vs. CC | 0.30 | 0.02 | 4.54 | 0.87 | 0.39 | 98% | <0.00001 | |
CG vs. CC | 1.08 | 0.92 | 1.28 | 0.94 | 0.35 | 0% | 0.87 | |
GG + CG vs. CC | 1.03 | 0.88 | 1.20 | 0.32 | 0.75 | 0% | 0.77 | |
GG vs. CC + CG | 0.84 | 0.50 | 1.39 | 0.69 | 0.49 | 50% | 0.16 | |
rs4150441 (2) | G vs. A | 1.09 | 0.88 | 1.34 | 0.80 | 0.43 | 0% | 0.85 |
GG vs. AA | 1.20 | 0.80 | 1.80 | 0.90 | 0.37 | 0% | 0.87 | |
AG vs. AA | 1.12 | 0.82 | 1.53 | 0.70 | 0.48 | 0% | 0.93 | |
GG + AG vs. AA | 1.26 | 0.95 | 1.67 | 1.59 | 0.11 | 0% | 0.47 | |
GG vs. AA + AG | 1.08 | 0.74 | 1.57 | 0.38 | 0.70 | 0% | 0.88 | |
rs1800975 (8) | A vs. G | 0.78 | 0.49 | 1.23 | 1.07 | 0.28 | 96% | <0.00001 |
AA vs. GG | 0.91 | 0.77 | 1.07 | 1.11 | 0.27 | 17% | 0.29 | |
GA vs. GG | 1.00 | 0.82 | 1.23 | 0.02 | 0.99 | 55% | 0.03 | |
AA + GA vs. GG | 0.94 | 0.85 | 1.06 | 1.01 | 0.31 | 43% | 0.09 | |
AA vs. GG + GA | 0.66 | 0.35 | 1.26 | 1.26 | 0.21 | 94% | <0.00001 |
Polymorphism (N) | Subgroup (N) | Variables | Allelic | Homozygous | Heterozygous | Dominant | Recessive |
---|---|---|---|---|---|---|---|
rs17655 (12) | Ethnicity | ||||||
Asian (7) | OR (95%CI) | 0.87 (0.79, 0.97) | 0.81 (0.67, 0.97) | 1.05 (0.67, 1.65) | 1.22 (0.66, 2.66) | 0.86 (0.68, 1.09) | |
p-value | 0.009 | 0.03 | 0.83 | 0.52 | 0.22 | ||
I2 | 67% | 50% | 85% | 93% | 52% | ||
Caucasian (2) | OR (95%CI) | 1.01 (0.82, 1.24) | 0.68 (0.37, 1.26) | 1.98 (0.97, 4.06) | 1.47 (0.98, 2.19) | 0.64 (0.35, 1.17) | |
p-value | 0.23 | 0.22 | 0.06 | 0.06 | 0.15 | ||
I2 | 0% | 0% | 81% | 93% | 0% | ||
Mixed (3) | OR (95%CI) | 1.05 (0.96, 1.15) | 1.01 (0.79, 1.28) | 1.39 (0.85, 2.28) | 1.76 (0.70, 4.42) | 0.93 (0.81, 1.07) | |
p-value | 0.30 | 0.95 | 0.19 | 0.23 | 0.31 | ||
I2 | 19% | 0% | 82% | 96% | 0% | ||
Sample size | |||||||
≥400 (6) | OR (95%CI) | 0.99 (0.92, 1.06) | 0.89 (0.75, 1.05) | 1.36 (0.90, 2.60) | 1.74 (1.03, 2.93) | 0.91 (0.82, 1.02) | |
p-value | 0.82 | 0.15 | 0.15 | 0.04 | 0.11 | ||
I2 | 53% | 28% | 90% | 95% | 36% | ||
<400 (6) | OR (95%CI) | 0.89 (0.77, 1.03) | 0.80 (0.60, 1.07) | 1.12 (0.74, 1.69) | 1.14 (0.60, 2.18) | 0.82 (0.64, 1.04) | |
p-value | 0.11 | 0.13 | 0.60 | 0.69 | 0.10 | ||
I2 | 61% | 50% | 65% | 88% | 32% | ||
Control source | |||||||
HB (7) | OR (95%CI) | 0.90 (0.77, 1.05) | 0.86 (0.64, 1.15) | 1.13 (0.73, 1.73) | 0.32 (0.74, 2.36) | 0.90 (0.73, 1.10) | |
p-value | 0.18 | 0.31 | 0.59 | <0.0001 | 0.29 | ||
I2 | 67% | 60% | 84% | 93% | 56% | ||
PB (5) | OR (95%CI) | 1.03 (0.93, 1.13) | 0.86 (0.67, 1.10) | 1.47 (0.89, 2.43) | 1.69 (0.87, 3.28) | 0.83 (0.69, 0.99) | |
p-value | 0.56 | 0.22 | 0.13 | 0.12 | 0.04 | ||
I2 | 1% | 0% | 89% | 95% | 0% | ||
Cancer subtype | |||||||
OC (3) | OR (95%CI) | 1.01 (0.82, 1.25) | 0.82 (0.59, 1.15) | 1.37 (0.71, 2.66) | 1.62 (0.65, 4.07) | 1.02 (0.71, 1.48) | |
p-value | 0.91 | 0.25 | 0.35 | 0.30 | 0.90 | ||
I2 | 10% | 0% | 75% | 89% | 0% | ||
LC (4) | OR (95%CI) | 0.80 (0.62, 1.04) | 0.60 (0.45, 0.76) | 1.11 (0.54, 2.29) | 0.90 (0.43, 1.89) | 0.64 (0.51, 0.82) | |
p-value | 0.10 | 0.0004 | 0.77 | 0.78 | 0.0003 | ||
I2 | 73% | 20% | 90% | 93% | 0% | ||
NPC (2) | OR (95%CI) | 0.99 (0.94, 1.04) | 0.98 (0.71, 1.35) | 1.21 (0.35, 4.19) | 2.67 (1.08, 6.63) | 0.93 (0.77, 1.12) | |
p-value | 0.68 | 0.90 | 0.77 | 0.03 | 0.43 | ||
I2 | 84% | 0% | 94% | 92% | 3% | ||
rs1800975 (8) | Ethnicity | ||||||
Asian (4) | OR (95%CI) | 0.99 (0.85, 1.15) | 0.97 (0.73, 1.29) | 1.22 (0.94, 2.95) | 1.08 (0.86, 1.35) | 0.89 (0.69, 1.14) | |
p-value | 0.88 | 0.86 | 0.13 | 0.53 | 0.35 | ||
I2 | 33% | 24% | 0% | 0% | 48% | ||
Caucasian (3) | OR (95%CI) | 0.53 (0.18, 1.59) | 0.83 (0.52, 1.32) | 0.80 (0.58, 1.10) | 0.81 (0.69, 0.96) | 0.26 (0.21, 0.33) | |
p-value | <0.0001 | 0.43 | 0.17 | 0.02 | <0.0001 | ||
I2 | 98% | 52% | 60% | 66% | 96% | ||
Mixed (1) | OR (95%CI) | 0.99 (0.86, 1.14) | 0.91 (0.68, 1.22) | 1.10 (0.90, 1.35) | 1.05 (0.87, 1.27) | 0.87 (0.66, 1.14) | |
p-value | 0.87 | 0.53 | 0.36 | 0.62 | 0.31 | ||
I2 | - | - | - | - | - | ||
Sample size | |||||||
≥400 (4) | OR (95%CI) | 0.72 (0.33, 1.57) | 0.95 (0.79, 1.15) | 0.97 (0.76, 1.24) | 0.97 (0.78, 1.21) | 0.63 (0.22, 1.82) | |
p-value | 0.41 | 0.62 | 0.81 | 0.81 | 0.39 | ||
I2 | 98% | 0% | 98% | 64% | 97% | ||
<400 (4) | OR (95%CI) | 0.87 (0.74, 1.03) | 0.79 (0.57, 1.10) | 1.08 (0.81, 1.44) | 0.90 (0.67, 1.22) | 0.76 (0.57, 1.01) | |
p-value | 0.12 | 0.17 | 0.59 | 0.50 | 0.06 | ||
I2 | 44% | 45% | 48% | 23% | 43% | ||
Control source | |||||||
HB (5) | OR (95%CI) | 0.73 (0.38, 1.43) | 0.91 (0.76, 1.09) | 1.04 (0.79, 1.38) | 0.96 (0.79, 1.17) | 0.44 (0.37, 0.52) | |
p-value | 0.36 | 0.30 | 0.75 | 0.67 | <0.0001 | ||
I2 | 98% | 11% | 69% | 51% | 95% | ||
PB (3) | OR (95%CI) | 0.91 (0.68, 1.20) | 0.92 (0.63, 1.35) | 0.97 (0.75, 1.26) | 0.89 (0.59, 1.35) | 0.83 (0.64, 1.08) | |
p-value | 0.50 | 0.68 | 0.83 | 0.59 | 0.17 | ||
I2 | 54% | 49% | 32% | 51% | 31% | ||
Cancer subtype | |||||||
OC (2) | OR (95%CI) | 084 (0.67, 1.06) | 0.70 (0.44, 1.13) | 1.41 (0.93, 2.15) | 0.96(0.66, 1.41) | 0.66 (0.45, 0.96) | |
p-value | 0.14 | 0.15 | 0.11 | 0.84 | 0.03 | ||
I2 | 4% | 8% | 0% | 0% | 36% | ||
LC (3) | OR (95%CI) | 1.09 (0.94, 1.27) | 1.16 (0.87, 1.55) | 1.09 (0.87, 1.36) | 1.11 (0.90, 1.36) | 1.12 (0.85, 1.46) | |
p-value | 0.24 | 0.31 | 0.47 | 0.32 | 0.42 | ||
I2 | 0% | 0% | 0% | 0% | 0% |
Polymorphism (N) | Variable | Model | Coefficient | Standard Error | 95% Lower | 95% Upper | Z-Value | p-Value |
---|---|---|---|---|---|---|---|---|
rs17655 (12) | Publication year | C vs. G | −0.0005 | 0.0003 | −0.0011 | 0.0001 | −1.57 | 0.1171 |
CC vs. GG | −0.0005 | 0.0006 | −0.0016 | 0.0006 | −0.93 | 0.3518 | ||
GC vs. GG | 0.0003 | 0.0010 | −0.0017 | 0.0023 | 0.28 | 0.7816 | ||
CC + GC vs. GG | −0.0007 | 0.0014 | −0.0033 | 0.0020 | −0.50 | 0.6152 | ||
CC vs. GG + GC | −0.0005 | 0.0004 | −0.0014 | 0.0003 | −1.18 | 0.2369 | ||
Sample size | C vs. G | 0.0001 | 0.0001 | −0.0001 | 0.0002 | 0.66 | 0.5112 | |
CC vs. GG | 0.0001 | 0.0002 | −0.0002 | 0.0005 | 0.66 | 0.5084 | ||
GC vs. GG | 0.0002 | 0.0003 | −0.0004 | 0.0009 | 0.72 | 0.4708 | ||
CC + GC vs. GG | 0.0002 | 0.0004 | −0.0007 | 0.0011 | 0.40 | 0.6867 | ||
CC vs. GG + GC | < 0.0001 | 0.0001 | −0.0003 | 0.0003 | 0.22 | 0.8232 | ||
Quality score | C vs. G | 0.1013 | 0.0790 | −0.0535 | 0.2561 | 1.28 | 0.1995 | |
CC vs. GG | 0.0961 | 0.1522 | −0.2022 | 0.3944 | 0.63 | 0.5278 | ||
GC vs. GG | −0.0671 | 0.2663 | −0.5890 | 0.4548 | −0.25 | 0.8010 | ||
CC + GC vs. GG | 0.1956 | 0.3539 | −0.4971 | 0.8902 | 0.56 | 0.5786 | ||
CC vs. GG + GC | 0.1062 | 0.1169 | −0.1229 | 0.3352 | 0.91 | 0.3636 | ||
rs1800975 (8) | Publication year | A vs. G | −0.0006 | 0.0018 | −0.0014 | 0.0030 | −0.32 | 0.7519 |
AA vs. GG | −0.0011 | 0.0010 | −0.0031 | 0.0010 | −1.04 | 0.2948 | ||
GA vs. GG | −0.0007 | 0.0009 | −0.0025 | 0.0012 | −0.71 | 0.4793 | ||
AA + GA vs. GG | −0.0008 | 0.0008 | −0.0024 | 0.0007 | −1.03 | 0.3045 | ||
AA vs. GG + GA | −0.0010 | 0.0025 | −0.0059 | 0.0039 | −0.40 | 0.6859 | ||
Sample size | A vs. G | −0.0005 | 0.0007 | −0.0018 | 0.0009 | −0.67 | 0.5021 | |
AA vs. GG | −0.0002 | 0.0003 | −0.0008 | 0.0004 | −0.70 | 0.4845 | ||
GA vs. GG | −0.0003 | 0.0003 | −0.0009 | 0.0004 | −0.83 | 0.4070 | ||
AA + GA vs. GG | −0.0002 | 0.0003 | −0.0007 | 0.0003 | −0.78 | 0.4328 | ||
AA vs. GG + GA | −0.0006 | 0.0009 | −0.0024 | 0.0012 | −0.66 | 0.5120 | ||
Quality score | A vs. G | 0.1647 | 0.5359 | −0.8830 | 1.2178 | 0.31 | 0.7548 | |
AA vs. GG | 0.2972 | 0.2988 | −0.2883 | 0.8828 | 0.99 | 0.3198 | ||
GA vs. GG | 0.2057 | 0.2717 | −0.3268 | 0.7381 | 0.76 | 0.4490 | ||
AA + GA vs. GG | 0.2352 | 0.2339 | −0.2232 | 0.6936 | 1.01 | 0.3145 | ||
AA vs. GG + GA | 0.2765 | 0.7316 | −1.1574 | 1.7104 | 0.38 | 0.7055 |
Polymorphism (Number of Studies without a Deviation) | Genetic Model | OR | 95%CI | Z-Value | p-Value | I2 | Pheterogeneity | |
---|---|---|---|---|---|---|---|---|
Min. | Max. | |||||||
rs17655 (5) | C vs. G | 0.99 | 0.90 | 1.09 | 0.25 | 0.81 | 0% | 0.85 |
CC vs. GG | 0.95 | 0.75 | 1.21 | 0.42 | 0.68 | 0% | 0.69 | |
GC vs. GG | 1.03 | 0.89 | 1.20 | 0.42 | 0.68 | 0% | 0.59 | |
CC + GC vs. GG | 1.00 | 0.87 | 1.15 | 0.01 | 0.99 | 30% | 0.22 | |
CC vs. GG + GC | 0.96 | 0.82 | 1.12 | 0.54 | 0.59 | 0% | 0.89 | |
rs1800975 (4) | A vs. G | 0.62 | 0.26 | 1.49 | 1.08 | 0.28 | 98% | <0.00001 |
AA vs. GG | 0.87 | 0.68 | 1.12 | 1.08 | 0.28 | 29% | 0.24 | |
GA vs. GG | 0.84 | 0.63 | 1.12 | 1.20 | 0.23 | 51% | 0.11 | |
AA + GA vs. GG | 0.84 | 0.63 | 1.11 | 1.22 | 0.22 | 55% | 0.08 | |
AA vs. GG + GA | 0.49 | 0.15 | 1.63 | 1.16 | 0.25 | 96% | <0.00001 |
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Imani, M.M.; Basamtabar, M.; Akbari, S.; Sadeghi, E.; Sadeghi, M. Relationship between XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 Polymorphisms and the Susceptibility to Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. Medicina 2024, 60, 478. https://doi.org/10.3390/medicina60030478
Imani MM, Basamtabar M, Akbari S, Sadeghi E, Sadeghi M. Relationship between XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 Polymorphisms and the Susceptibility to Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. Medicina. 2024; 60(3):478. https://doi.org/10.3390/medicina60030478
Chicago/Turabian StyleImani, Mohammad Moslem, Masoumeh Basamtabar, Sattar Akbari, Edris Sadeghi, and Masoud Sadeghi. 2024. "Relationship between XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 Polymorphisms and the Susceptibility to Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis" Medicina 60, no. 3: 478. https://doi.org/10.3390/medicina60030478