Exploring the Spectrum of Visual Illusions and Other Minor Hallucinations in Patients with Parkinson’s Disease in Lithuania
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Background Motor and Cognitive Assessments
2.3. Assessment of Visual Illusions and Other Minor Hallucinations
2.4. Statistical Analysis of Data
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Fernandez, H.H.; Aarsland, D.; Fénelon, G.; Friedman, J.H.; Marsh, L.; Tröster, A.I.; Poewe, W.; Rascol, O.; Sampaio, C.; Stebbins, G.T.; et al. Scales to assess psychosis in Parkinson’s disease: Critique and recommendations. Mov. Disord. 2008, 23, 484–500. [Google Scholar] [CrossRef]
- Goetz, C.G.; Stebbins, G.T. Risk factors for nursing home placement in advanced Parkinson’s disease. Neurology 1993, 43, 2227. [Google Scholar] [CrossRef]
- Aarsland, D.; Larsen, J.P.; Tandberg, E.; Laake, K. Predictors of nursing home placement in Parkinson’s disease: A population-based, prospective study. J. Am. Geriatr. Soc. 2000, 48, 938–942. [Google Scholar] [CrossRef]
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders; American Psychiatric Association: Arlington, VA, USA, 2013. [Google Scholar] [CrossRef]
- Chendo, I.; Fabbri, M.; Godinho, C.; Simões, R.M.; Sousa, C.S.; Coelho, M.; Voon, V.; Ferreira, J.J. High frequency of psychosis in late-stage Parkinsońs disease. Clin. Park. Relat. Disord. 2021, 5, 100119. [Google Scholar] [CrossRef]
- Ravina, B.; Marder, K.; Fernandez, H.H.; Friedman, J.H.; McDonald, W.; Murphy, D.; Aarsland, D.; Babcock, D.; Cummings, J.; Endicott, J.; et al. Diagnostic criteria for psychosis in Parkinson’s disease: Report of an NINDS, NIMH work group. Mov. Disord. 2007, 22, 1061–1068. [Google Scholar] [CrossRef]
- Pagonabarraga, J.; Martinez-Horta, S.; de Bobadilla, R.F.; Pérez, J.; Ribosa-Nogué, R.; Marín, J.; Pascual-Sedano, B.; García, C.; Gironell, A.; Kulisevsky, J. Minor hallucinations occur in drug-naive Parkinson’s disease patients, even from the premotor phase. Mov. Disord. 2016, 31, 45–52. [Google Scholar] [CrossRef]
- Timofejavaitė, R.; Vilda, V.; Liveikienė, A.; Kaladytė-Lokominienė, R. Disturbances of visual perception in non-demented patients with Parkinson’s disease. Neurol. Semin. 2019, 23, 154–163. [Google Scholar] [CrossRef]
- Sasaki, C.; Yokoi, K.; Takahashi, H.; Hatakeyama, T.; Obara, K.; Wada, C.; Hirayama, K. Visual illusions in Parkinson’s disease: An interview survey of symptomatology. Psychogeriatrics 2022, 22, 38–48. [Google Scholar] [CrossRef]
- Jankovic, J.; McDermott, M.; Carter, J.; Gauthier, S.; Goetz, C.; Golbe, L.; Huber, S.; Koller, W.; Olanow, C.; Shoulson, I.; et al. Variable expression of Parkinson’s disease. Neurology 1990, 40, 1529. [Google Scholar] [CrossRef]
- Zhong, M.; Gu, R.; Zhu, S.; Bai, Y.; Wu, Z.; Jiang, X.; Shen, B.; Zhu, J.; Pan, Y.; Yan, J.; et al. Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease. Behav. Neurol. 2021, 2021, 3469706. [Google Scholar] [CrossRef]
- Nishio, Y.; Yokoi, K.; Hirayama, K.; Ishioka, T.; Hosokai, Y.; Gang, M.; Uchiyama, M.; Baba, T.; Suzuki, K.; Takeda, A.; et al. Defining visual illusions in Parkinson’s disease: Kinetopsia and object misidentification illusions. Park. Relat. Disord. 2018, 55, 111–116. [Google Scholar] [CrossRef]
- Statucka, M.; Cohn, M. Origins Matter: Culture Impacts Cognitive Testing in Parkinson’s Disease. Front. Hum. Neurosci. 2019, 13, 269. [Google Scholar] [CrossRef]
- Omoto, S.; Murakami, H.; Shiraishi, T.; Bono, K.; Umehara, T.; Iguchi, Y. Risk factors for minor hallucinations in Parkinson’s disease. Acta Neurol. Scand. 2021, 143, 538–544. [Google Scholar] [CrossRef]
- Marques, A.; Beze, S.; Pereira, B.; Chassain, C.; Monneyron, N.; Delaby, L.; Lambert, C.; Fontaine, M.; Derost, P.; Debilly, B.; et al. Visual hallucinations and illusions in Parkinson’s disease: The role of ocular pathology. J. Neurol. 2020, 267, 2829–2841. [Google Scholar] [CrossRef]
- Ffytche, D.H.; Creese, B.; Politis, M.; Chaudhuri, K.R.; Weintraub, D.; Ballard, C.; Aarsland, D. The psychosis spectrum in Parkinson disease. Nat. Rev. Neurol. 2017, 13, 81–95. [Google Scholar] [CrossRef]
- Diederich, N.J.; Goetz, C.G.; Stebbins, G.T. Repeated visual hallucinations in Parkinson’s disease as disturbed external/internal perceptions: Focused review and a new integrative model. Mov. Disord. 2005, 20, 130–140. [Google Scholar] [CrossRef]
- Brandies, R.; Yehuda, S. The possible role of retinal dopaminergic system in visual performance. Neurosci. Biobehav. Rev. 2008, 32, 611–656. [Google Scholar] [CrossRef]
- Wang, Y.; Li, D.; Chen, Y.; Zhu, S.; Jiang, X.; Jiang, Y.; Gu, R.; Shen, B.; Zhu, J.; Pan, Y.; et al. Clinical features of minor hallucinations in different phenotypes of Parkinson’s disease: A cross-sectional study. Front. Neurol. 2023, 14, 1158188. [Google Scholar] [CrossRef]
- Lenka, A.; Pagonabarraga, J.; Pal, P.K.; Bejr-Kasem, H.; Kulisvesky, J. Minor hallucinations in Parkinson disease. Neurology 2019, 93, 259–266. [Google Scholar] [CrossRef]
- Beze, S.; Castellani, L.; Pereira, B.; Chiambaretta, F.; Durif, F.; Marques, A. Two-year longitudinal follow-up of visual illusions and hallucinations in Parkinson’s disease. J. Neurol. 2022, 269, 4546–4554. [Google Scholar] [CrossRef]
- Baik, K.; Kim, Y.J.; Park, M.; Chung, S.J.; Sohn, Y.H.; Jeong, Y.; Lee, P.H. Functional Brain Networks of Minor and Well-Structured Major Hallucinations in Parkinson’s Disease. Mov. Disord. 2024, 39, 318–327. [Google Scholar] [CrossRef] [PubMed]
- Bejr-Kasem, H.; Sampedro, F.; Marín-Lahoz, J.; Martínez-Horta, S.; Pagonabarraga, J.; Kulisevsky, J. Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson’s disease. Eur. J. Neurol. 2020, 28, 438–447. [Google Scholar] [CrossRef] [PubMed]
Phenomenon | Definition | Example |
---|---|---|
Metachromatopsia | The color of an object seems different | A blue cup seems red |
Textural illusion | The surface of an object seems different | A flat table seems wavy |
Dysmorphopsia | The shape of an object seems different | A straight candle seems distorted or bent in two |
Macropsia | An object seems bigger in size | A cherry seems as big as an apple |
Micropsia | An object seems smaller in size | An apple seems as small as a cherry |
Teleopsia | An object seems farther than in reality | A table within arm’s reach seems a few meters away |
Pelopsia | An object seems nearer than in reality | A table a few meters away seems within arm’s reach |
Kinetopsia | A stationary object seems to be in motion | A stationary lamp seems to be moving, while other objects stay still |
Akinetopsia | A moving object seems to be still | A person walking in front seems to suddenly stop, even though he is still moving |
Zeitraffer phenomenon | An object seems to be moving faster | A slowly walking person seems to be running |
Zeitlupen phenomenon | An object seems to be moving slower | A rapidly moving dog seems to be slowly walking |
Tilt illusion | An object or the visual scene seems tilted | A candle on a table seems to be tilted by 45 degrees |
Upside-down illusion | An object or the visual scene seems inverted | A clock seems inverted |
Polyopia/cerebral diplopia | A single object appears as multiple (≥2), while other objects do not change in count; classified as cerebral diplopia if the number of objects “increases” upon continuous viewing | One painting appears as three paintings, while the number of other objects remains constant |
Visual perseveration | Ongoing perception of an object after it has moved out of the visual field; classified as immediate perseveration/palinopsia (after a few minutes)/hallucinatory palinopsia (after a few days or later) | A person “re-appears” at the door after leaving the house a few minutes ago |
Complex visual illusion | One object seems like another kind of object | A tree outside the window seems to be a person |
Surface orientation illusion | False perception of surface orientation | A flat street seems to be going downhill |
Passage hallucinations | Fleeting, vague images in the peripheral vision | A shadow of a dog is seen in the corner of the eye but disappears upon closer look |
Presence hallucinations | False sensation that another person is present nearby when nobody is actually there | The sensation that another person is present behind one’s back when there is no one else in the room |
Visual hallucinations | Abnormal visual perceptions without a physical stimulus | Despite the table being empty, there seems to be a book on it |
Clinical Characteristics | PD Group (n = 35) | Control Group (n = 35) |
---|---|---|
Sex, female | 17 (48.6%) | 17 (48.6%) |
Age, years | 67.0 (63.0–71.0) | 67.0 (62.0–75.0) |
Education, years | 14.0 (12.0–16.0) | 13.0 (12.0–18.0) |
MoCA, points | 23.0 (21.0–25.0) | 24.0 (22.0–27.0) |
Disease duration, years | 8.0 (3.0–12.0) | NA |
Modified Hoehn and Yahr stage | 2.5 (2.0–3.0) | NA |
LEDD, mg | 700 (400–1150) | NA |
PD with Visual Illusions (n = 13) | PD without Visual Illusions (n = 22) | p Value | |
---|---|---|---|
Sex, female | 5 (38.5%) | 12 (54.5%) | 0.489 |
Age, years | 67.0 (61.0–70.5) | 67.5 (63.0–72.25) | 0.719 |
Education, years | 15.0 (12.5–16.5) | 14.0 (12.0–16.0) | 0.262 |
MoCA, points | 22.0 (21.0–25.0) | 23.5 (21.0–26.0) | 0.201 |
Disease duration, years | 10.0 (2.8–13.0) | 7.0 (3.75–11.0) | 0.504 |
Hoehn and Yahr stage | 2.5 (2.0–3.0) | 2.0 (2.0–3.0) | 0.507 |
LEDD, mg | 1003 (350.0–1457.0) | 670.5 (468.8–856.3) | 0.290 |
History of dopamine agonist use | 10 (76.9%) | 15 (68.2%) | 0.709 |
History of amantadine use | 7 (53.8%) | 12 (54.5%) | 1 |
History of trihexyphenidyl use | 1 (7.7%) | 1 (4.5%) | 1 |
Visual hallucinations reported | 3 (23.1%) | 1 (4.5%) | 0.134 |
Passage hallucinations reported | 4 (30.8%) | 3 (18.2%) | 0.383 |
Presence hallucinations reported | 7 (53.8%) | 1 (4.5%) | 0.002 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Jucevičiūtė, N.; Balnytė, R.; Laucius, O. Exploring the Spectrum of Visual Illusions and Other Minor Hallucinations in Patients with Parkinson’s Disease in Lithuania. Medicina 2024, 60, 606. https://doi.org/10.3390/medicina60040606
Jucevičiūtė N, Balnytė R, Laucius O. Exploring the Spectrum of Visual Illusions and Other Minor Hallucinations in Patients with Parkinson’s Disease in Lithuania. Medicina. 2024; 60(4):606. https://doi.org/10.3390/medicina60040606
Chicago/Turabian StyleJucevičiūtė, Neringa, Renata Balnytė, and Ovidijus Laucius. 2024. "Exploring the Spectrum of Visual Illusions and Other Minor Hallucinations in Patients with Parkinson’s Disease in Lithuania" Medicina 60, no. 4: 606. https://doi.org/10.3390/medicina60040606