Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Collection of Clinical Data
2.2. Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Patients (n = 356) | FH Negative (n = 330) | FH Positive (n = 26) | p-Value | |
---|---|---|---|---|
Age (years) | 67.2 ± 10.3 | 67.6 ± 9.6 | 62.2 ± 15.9 | 0.009 |
Sex (female:male) | 210:146 | 196:134 | 14:12 | 0.580 |
Education (years) | 8.9 ± 4.8 | 8.8 ± 4.8 | 10.2 ± 4.3 | 0.152 |
Age at onset (years) | 65.6 ± 9.7 | 65.9 ± 9.7 | 62.8 ± 10.2 | 0.128 |
Duration of disease (months) | 20.1 ± 22.3 | 20.4 ± 22.7 | 16.4 ± 16.2 | 0.373 |
mHY stage | 1.9 ± 0.7 | 1.9 ± 0.7 | 2.0 ± 0.5 | 0.584 |
UPDRS part III score | 21.8 ± 10.5 | 21.8 ± 10.7 | 22.5 ± 8.1 | 0.751 |
UPDRS part II score | 7.1 ± 6.3 | 7.1 ± 6.4 | 6.0 ± 5.2 | 0.389 |
NMSS total score | 48.3 ± 33.3 | 48.3 ± 33.5 | 48.2 ± 31.1 | 0.989 |
MMSE | 26.0 ± 3.7 | 25.9 ± 3.8 | 26.6 ± 2.6 | 0.358 |
BDI | 11.6 ± 10.0 | 11.7 ± 10.1 | 10.7 ± 8.2 | 0.636 |
FH Negative (n = 330) | FH Positive (n = 26) | p-Value | |
---|---|---|---|
Tremor | 2.7 ± 2.5 | 2.4 ± 2.1 | 0.549 |
Rest tremor | 1.7 ± 1.9 | 1.3 ± 1.4 | 0.308 |
Action tremor | 1.0 ± 1.2 | 1.1 ± 1.3 | 0.724 |
Bradykinesia | 10.6 ± 5.3 | 11.1 ± 4.1 | 0.696 |
Rigidity | 5.0 ± 2.9 | 6.1 ± 2.4 | 0.036 (0.032 *) |
Gait and Posture | 1.4 ± 2.3 | 1.0 ± 1.6 | 0.396 |
FH Negative (n = 330) | FH Positive (n = 26) | p-Value | |
---|---|---|---|
Tremor-dominant | 100 | 6 | 0.722 |
Mixed | 35 | 3 | |
Akinetic-rigid | 194 | 17 |
FH Negative (n = 330) | FH Positive (n = 26) | p-Value | |
---|---|---|---|
D1 falls/cardiovascular | 2.5 ± 3.9 | 1.1 ± 1.7 | 0.001 (0.119 *) |
D2 sleep/fatigue | 9.3 ± 8.0 | 8.1 ± 8.8 | 0.496 |
D3 mood/cognition | 7.6 ± 8.2 | 10.5 ± 9.9 | 0.086 |
D4 perception/hallucination | 0.2 ± 1.0 | 0.3 ± 1.2 | 0.565 |
D5 attention/memory | 3.9 ± 4.8 | 3.3 ± 4.0 | 0.571 |
D6 gastrointestinal | 5.7 ± 6.1 | 5.5 ± 5.7 | 0.853 |
D7 urinary | 14.8 ± 12.6 | 15.6 ± 14.2 | 0.764 |
D8 sexual | 0.5 ± 1.6 | 0.3 ± 1.5 | 0.566 |
D9 others | 3.6 ± 4.9 | 3.2 ± 3.1 | 0.708 |
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Kim, H.; Choi, S.-M.; Lee, H.-L.; Cho, S.H.; Kim, B.C. Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History. Medicina 2024, 60, 1378. https://doi.org/10.3390/medicina60091378
Kim H, Choi S-M, Lee H-L, Cho SH, Kim BC. Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History. Medicina. 2024; 60(9):1378. https://doi.org/10.3390/medicina60091378
Chicago/Turabian StyleKim, Hyunsoo, Seong-Min Choi, Hak-Loh Lee, Soo Hyun Cho, and Byeong C. Kim. 2024. "Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History" Medicina 60, no. 9: 1378. https://doi.org/10.3390/medicina60091378