Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review
Abstract
:1. Introduction
2. Materials and Methods
3. Oral Microbiota
Functions and Role
Gram-Positive | Gram-Negative |
|
|
4. Gut Microbiota
Composition and Function
5. Interactions between Oral and Gut Microbiota
5.1. Swallowing and Microbial Transfer
5.2. Mendelian Randomization Test
5.3. Complications and Relation with Other Systemic Diseases
5.3.1. Esophagus and Stomach
5.3.2. Pancreas
5.3.3. Gallbladder
5.3.4. Colorectal Cancer
6. Therapeutic Innovations
7. Discussion
8. Conclusions
9. Recommendation for Future Research
- Develop treatments that target both oral and gut dysbiosis, which could help reduce periodontal disease progression and improve gut health.
- Conduct randomized clinical trials to investigate the periodontitis–IBD connection and optimize treatment approaches.
- Investigate therapeutic drugs that target Fna C2 strains in colorectal cancer.
- Explore how gut dysbiosis influences periodontitis, as this mechanism is not yet fully understood.
- Examine how periodontal pathogens promote various signaling pathways in carcinogenesis, which could reveal opportunities for prevention and targeted interventions.
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sulaiman, Y.; Pacauskienė, I.M.; Šadzevičienė, R.; Anuzyte, R. Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review. Medicina 2024, 60, 1416. https://doi.org/10.3390/medicina60091416
Sulaiman Y, Pacauskienė IM, Šadzevičienė R, Anuzyte R. Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review. Medicina. 2024; 60(9):1416. https://doi.org/10.3390/medicina60091416
Chicago/Turabian StyleSulaiman, Yaman, Ingrida Marija Pacauskienė, Renata Šadzevičienė, and Rugile Anuzyte. 2024. "Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review" Medicina 60, no. 9: 1416. https://doi.org/10.3390/medicina60091416