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Marine Drugs, Volume 18, Issue 6

June 2020 - 57 articles

Streptomycetes are an important source of natural products potentially applicable in the pharmaceutical industry. The biosynthetic genes of these drugs are very often poorly expressed under laboratory cultivation conditions. Antibiotic-resistant mutants exhibit in many cases increased production of natural drugs. In this study, we report the induction of a type II polyketide synthase gene cluster in the marine strain Streptomyces albus subsp. chlorinus through selection of streptomycin resistant mutants, resulting in overproduction of the novel compound fredericamycin C2. The new fredericamycin is structurally related to the potent antitumor drug lead fredericamycin A.
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Cover Story: Streptomycetes are an important source of natural products potentially applicable in the pharmaceutical industry. The biosynthetic genes of these drugs are very often poorly expressed under laboratory cultivation conditions. Antibiotic-resistant mutants exhibit in many cases increased production of natural drugs. In this study, we report the induction of a type II polyketide synthase gene cluster in the marine strain Streptomyces albus subsp. chlorinus through selection of streptomycin resistant mutants, resulting in overproduction of the novel compound fredericamycin C2. The new fredericamycin is structurally related to the potent antitumor drug lead fredericamycin A. View this paper.

Articles (57)

  • Article
  • Open Access
26 Citations
4,362 Views
21 Pages
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Degradation of Sargassum crassifolium Fucoidan by Ascorbic Acid and Hydrogen Peroxide, and Compositional, Structural, and In Vitro Anti-Lung Cancer Analyses of the Degradation Products

  • Tien-Chiu Wu,
  • Yong-Han Hong,
  • Yung-Hsiang Tsai,
  • Shu-Ling Hsieh,
  • Ren-Han Huang,
  • Chia-Hung Kuo and
  • Chun-Yung Huang
Mar. Drugs2020, 18(6), 334;https://doi.org/10.3390/md18060334

26 June 2020

Fucoidans possess multiple biological functions including anti-cancer activity. Moreover, low-molecular-weight fucoidans are reported to possess more bioactivities than native fucoidans. In the present study, a native fucoidan (SC) was extracted from...

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  • Article
  • Open Access
27 Citations
5,003 Views
15 Pages
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Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

  • Francisca García,
  • Pedro Lobos,
  • Alejandra Ponce,
  • Karla Cataldo,
  • Daniela Meza,
  • Patricio Farías,
  • Carolina Estay,
  • Felipe Oyarzun-Ampuero,
  • Rodrigo Herrera-Molina and
  • Andrea Paula-Lima
  • + 4 authors
Mar. Drugs2020, 18(6), 335;https://doi.org/10.3390/md18060335

26 June 2020

Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen sp...

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  • Article
  • Open Access
13 Citations
3,669 Views
10 Pages
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Efficient Preparation of Bafilomycin A1 from Marine Streptomyces lohii Fermentation Using Three-Phase Extraction and High-Speed Counter-Current Chromatography

  • Ye Yuan,
  • Xiaoping He,
  • Tingting Wang,
  • Xingwang Zhang,
  • Zhong Li,
  • Xiaoqing Xu,
  • Weiyan Zhang,
  • Xiaojun Yan,
  • Shengying Li and
  • Shan He
Mar. Drugs2020, 18(6), 332;https://doi.org/10.3390/md18060332

25 June 2020

An efficient strategy was developed for the rapid separation and enrichment of bafilomycin A1 (baf A1) from a crude extract of the marine microorganism Streptomyces lohii fermentation. This strategy comprises liquid−liquid extraction (LLE) with...

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  • Article
  • Open Access
26 Citations
4,231 Views
18 Pages
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Protective Effect of Fucoidan against MPP+-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway

  • Huaide Liu,
  • Jing Wang,
  • Quanbin Zhang,
  • Lihua Geng,
  • Yue Yang and
  • Ning Wu
Mar. Drugs2020, 18(6), 333;https://doi.org/10.3390/md18060333

25 June 2020

The main pathologic changes of the Parkinson’s disease (PD) is dopaminergic (DA) neurons lost. Apoptosis was one of the important reasons involved in the DA lost. Our previous study found a fucoidan fraction sulfated heterosaccharide (UF) had n...

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  • Article
  • Open Access
59 Citations
5,085 Views
17 Pages
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Fucoidan Isolated from Saccharina japonica Inhibits LPS-Induced Inflammation in Macrophages via Blocking NF-κB, MAPK and JAK-STAT Pathways

  • Jing Ye,
  • Donghui Chen,
  • Zhicheng Ye,
  • Yayan Huang,
  • Na Zhang,
  • Edmund M. K. Lui,
  • Changhu Xue and
  • Meitian Xiao
Mar. Drugs2020, 18(6), 328;https://doi.org/10.3390/md18060328

24 June 2020

Fucoidan has been reported to have a variety of biological activities. However, different algae species, extraction methods, harvesting seasons, and growth regions lead to the structural variation of fucoidan, which would affect the bioactivities of...

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  • Feature Paper
  • Article
  • Open Access
12 Citations
4,374 Views
22 Pages
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The Advanced Floating Chirality Distance Geometry Approach―How Anisotropic NMR Parameters Can Support the Determination of the Relative Configuration of Natural Products

  • Matthias Köck,
  • Michael Reggelin and
  • Stefan Immel
Mar. Drugs2020, 18(6), 330;https://doi.org/10.3390/md18060330

24 June 2020

The configurational analysis of complex natural products by NMR spectroscopy is still a challenging task. The assignment of the relative configuration is usually carried out by analysis of interproton distances from NOESY or ROESY spectra (qualitativ...

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  • Review
  • Open Access
50 Citations
7,885 Views
43 Pages
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Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

  • Rajiv Dahiya,
  • Sunita Dahiya,
  • Neeraj Kumar Fuloria,
  • Suresh Kumar,
  • Rita Mourya,
  • Suresh V. Chennupati,
  • Satish Jankie,
  • Hemendra Gautam,
  • Sunil Singh and
  • Sanjay Kumar Karan
  • + 8 authors
Mar. Drugs2020, 18(6), 329;https://doi.org/10.3390/md18060329

24 June 2020

Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-rangin...

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  • Article
  • Open Access
145 Citations
12,028 Views
21 Pages
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LC-ESI-QTOF-MS/MS Characterization of Seaweed Phenolics and Their Antioxidant Potential

  • Biming Zhong,
  • Nicholas A. Robinson,
  • Robyn D. Warner,
  • Colin J. Barrow,
  • Frank R. Dunshea and
  • Hafiz A.R. Suleria
Mar. Drugs2020, 18(6), 331;https://doi.org/10.3390/md18060331

24 June 2020

Seaweed is an important food widely consumed in Asian countries. Seaweed has a diverse array of bioactive compounds, including dietary fiber, carbohydrate, protein, fatty acid, minerals and polyphenols, which contribute to the health benefits and com...

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  • Article
  • Open Access
26 Citations
4,433 Views
15 Pages
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In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa

  • Dawrin Pech-Puch,
  • Mar Pérez-Povedano,
  • Marta Martinez-Guitian,
  • Cristina Lasarte-Monterrubio,
  • Juan Carlos Vázquez-Ucha,
  • Germán Bou,
  • Jaime Rodríguez,
  • Alejandro Beceiro and
  • Carlos Jimenez
Mar. Drugs2020, 18(6), 326;https://doi.org/10.3390/md18060326

23 June 2020

The pyrrole-imidazoles, a group of alkaloids commonly found in marine sponges belonging to the genus Agelas, display a wide range of biological activities. Herein, we report the first chemical study of the secondary metabolites of the sponge A. dilat...

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  • Article
  • Open Access
21 Citations
5,402 Views
14 Pages
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Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica

  • Alexandre Bory,
  • Andrew J. Shilling,
  • Jessie Allen,
  • Ala Azhari,
  • Alison Roth,
  • Lindsey N. Shaw,
  • Dennis E. Kyle,
  • John H. Adams,
  • Charles D. Amsler and
  • James B. McClintock
  • + 1 author
Mar. Drugs2020, 18(6), 327;https://doi.org/10.3390/md18060327

23 June 2020

The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites...

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