Calcium Channel Blocker-Associated Chyloperitoneum in Patients Receiving Peritoneal Dialysis: A Systematic Review
Abstract
:1. Introduction
2. Methods
2.1. Search Strategy
2.2. Study Selection
2.3. Data Extraction and Analysis
3. Results
3.1. Literature Search and Study Characteristics
3.2. Characteristics of Chyloperitoneum
3.3. Study Quality
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Study | Country | Study Design | Number of Patients | Drug Name | Dose (mg) | Prevalence of CP | Age (mean ± SD, year) | Sex (men, %) | TGs in Dialysate (mean ± SD, mg/dL) | TGs in Serum (mean ± SD, mg/dl) | Duration of PD Treatment (mean ± SD, months) | Time-to-Onset of CP (mean ± SD, days) | Result of Withdrawal | Result of Rechallenge | QA Score (0–7) a | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T | Non-T | T | Non-T | T | Non-T | T | Non-T | T | Non-T | |||||||||||
Hsiao 2010 [21] | Taiwan | P | 40 | Lercanidipine | 5 | 22.5% (9/40) | 39.4 ± 14.3 | 47.5 ± 12.5 | 44.4 | 38.7 | 19.3 ± 6.3 | 0 | 123 ± 43 | 151 ± 52 | 33 ± 21 | 39 ± 24 | 1.2 ± 0.4 | Dialysate clear within 24 h | Cloudy again | 5 |
Yang 2008 [23] | Taiwan | R | 14 | Lercanidipine | - | 57.14% (8/14) | 52.6 ± 18.5 | 46.0 ± 10.8 | 62.5 | 33.3 | 128.4 | 6.5 | 218.0 ± 176.6 | 115.8 ± 3.2 | 20.4 ± 21.6 | 33.6 ± 24 | 38.5 ± 60.8 | Dialysate clear within 24 h | Cloudy again | 6 |
Topal 2006 b [22] | Turkey | R | 23 | Lercanidipine | 5 | 13.04% (3/23) | 45.3 ± 17.6 | 39.1 | - | - | 15.9±11.6 | 1 | - | - | 3 | |||||
Yoshimoto 1998 [11] | Japan | R | 251 | Various CCBs c | - | 7.57% (19/251) | 55 ± 17 | 50 ± 12 | 52.6 | 67.7 | - | - | - | - | Dialysate clear | Cloudy again | 4 |
Study | Country | Study Design | Number of Patients | Drug Name | Dose | Age | Sex | TGs in Dialysate (mg/dL) | TGs in Serum (mg/dL) | Duration of PD Treatment | Time-to-Onset of CP | Result of Withdrawal | Result of Rechallenge | Causality a |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Betancourt 2013 [24] | Spain | Case series | 4 | Manidipine | - | 60 y | M | 52 | - | 2 mo | - | Dialysate clear | - | Probable |
Verapamil | - | 41 y | M | 9 | - | 4 mo | - | Dialysate clear | - | Probable | ||||
Manidipine | - | 70 y | F | 745 | - | 4 d | - | Dialysate clear | - | Probable | ||||
Manidipine | - | 52 y | M | 452 | - | 5 mo | - | Dialysate clear | - | Probable | ||||
Nicotera 2018 [33] | Italy | Case report | 1 | Lercanidipine | 20 mg | 53 y | - | 150 | - | 2 y | - | Dialysate clear immediately | - | Probable |
Gupta 2016 [13] | India | Case report | 1 | Amlodipine | 5 mg | 65 y | M | 293.8 | 88.4 | 8 d | 3 d | Dialysate clear within 24 h | Not-rechallenged | Probable |
Moreiras 2014 [32] | Spain | Case report | 1 | Lercanidipine | 5 mg | 59 y | F | 20 | 182 | - | 3 d | Dialysate clear within 24 h | Cloudy again | Certain (or definite) |
Mallett 2012 [34] | Northern Ireland | Case report | 1 | Amlodipine | 0.6 mg/kg | 7 mo | M | 57.5 | 164.6 | 5 mo | 2 d | Dialysate clear before withdrawal b | TG slightly increased in dialysate | Probable |
Ram 2012 [31] | India | Case report | 1 | Diltiazem | - | 55y | M | 61 | 134 | - | - | Dialysate clear after 1 d | Cloudy again | Certain (or definite) |
Lopez 2011 [12] | Spain | Case report | 1 | Manidipine (from nifedipine OROS) | - | 44 y | F | 119 | 76 | - | 1 d | Dialysate clear within 24 h | - | Probable |
Tsao 2009 [30] | Taiwan | Case report | 1 | Lercanidipine | 10 mg | 41 y | F | 251 | - | 2 wk | 3 d | Dialysate clear within 24 h | Cloudy again | Certain (or definite) |
Roh 1999 [29] | Korea | Case report | 1 | Manidipine | 40 mg | 47 y | M | 28 | 111 | 9 d | 1 d | Dialysate clear after 1 d | Not-rechallenged | Probable |
Tsurusaki 1995 [28] | Japan | Case report | 1 | Manidipine | 20 mg | 36 y | M | 27.2 | - | 32 mo | 4 d | Dialysate clear within 24 h | - | Probable |
Fujii 1995 [27] | Japan | Case report | 1 | Manidipine | 10 mg | 58 y | M | 26 | - | 2 mo | 3 d | Dialysate clear within 24 h | - | Probable |
Kato 1994 [26] | Japan | Case report | 1 | Manidipine | 40 mg (From 20 mg) | 51 y | F | 29 | 121 | 4 mo | 1 d | Dialysate clear within 12 h | - | Probable |
Atsuko 1993 [25] | Japan | Case report | 1 | Manidipine | 20 mg | 44 y | M | 24 | 81 | 6 mo | 8 h | Dialysate clear within 1 d | Cloudy again | Certain (or definite) |
Study | Criteria of modified Newcastle–Ottawa Scale | ||||||
---|---|---|---|---|---|---|---|
Prior Criteria; Representativeness | Ascertainment of Exposure | Starting Condition Prior to Outcome | Adjustment for Confounding Factors a | Ascertainment of Outcome | Sufficiency of Follow-Up Period | Adequacy of Follow-Up | |
Hsiao 2010 [21] | Lack of detailed description of selection criteria | Medical records | Chyloperitoneum was not pre sent | Infection and other causes | Standardised assessment | No statement | Complete follow-up |
Yang 2008 [23] | Lack of detailed description of selection criteria | Medical records | Chyloperitoneum was not present | Infection and other causes | Standardised assessment | Follow-up period ≥ 30 d | More than 90% |
Topal 2006 [22] | Unclear | Medical records | Chyloperitoneum was not present | Infection | Visual observation; Turbidity of peritoneal dialysate | Not sufficient; 1 d | Complete follow-up |
Yoshimoto 1998 [11] | Participant selection by researchers | Medical records | Chyloperitoneum was not present | Infection and other causes | Standardised assessment | Not sufficient; 2 d | Subsequent observation by a biochemical test was performed on 53% of the patients |
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Kim, S.; Yu, Y.M.; Kwon, J.; Yoo, H.; Jung, S.H.; Lee, E. Calcium Channel Blocker-Associated Chyloperitoneum in Patients Receiving Peritoneal Dialysis: A Systematic Review. Int. J. Environ. Res. Public Health 2019, 16, 1333. https://doi.org/10.3390/ijerph16081333
Kim S, Yu YM, Kwon J, Yoo H, Jung SH, Lee E. Calcium Channel Blocker-Associated Chyloperitoneum in Patients Receiving Peritoneal Dialysis: A Systematic Review. International Journal of Environmental Research and Public Health. 2019; 16(8):1333. https://doi.org/10.3390/ijerph16081333
Chicago/Turabian StyleKim, Seungyeon, Yun Mi Yu, Jeongyoon Kwon, Hyejin Yoo, Sun Hoi Jung, and Euni Lee. 2019. "Calcium Channel Blocker-Associated Chyloperitoneum in Patients Receiving Peritoneal Dialysis: A Systematic Review" International Journal of Environmental Research and Public Health 16, no. 8: 1333. https://doi.org/10.3390/ijerph16081333