Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats

Mandal, Tapas K.; Parvin, Nargish; Joo, Sang Woo; Roy, Partha

doi:10.3390/ijerph17041143

Open AccessArticle

Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats

¹

Department of Biotechnology, Indian Institute of Technology, Roorkee 247667, India

²

School of Mechanical Engineering and IT, Yeungnam University, Gyeongsan 38541, Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this manuscript.

Int. J. Environ. Res. Public Health 2020, 17(4), 1143; https://doi.org/10.3390/ijerph17041143

Submission received: 25 January 2020 / Revised: 6 February 2020 / Accepted: 7 February 2020 / Published: 11 February 2020

(This article belongs to the Section Toxicology and Public Health)

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Abstract

Triclosan (TCS) is a widely used chemical in personal care and household products as an antimicrobial agent but some studies have reported it as being estrogenic. We investigated the influence of TCS on the male reproductive system of postnatal pups. Lactating mother rats (Rattus norvegicus) were given daily doses of 0 mg, 3 mg, and 5 mg/kg/day from the day of delivery until 28 days, equivalent to their natural breastfeeding duration. At 28 days, the male pups of all three groups were sacrificed and their biochemical parameters evaluated. TCS-treated pups had decreased mRNA levels for 3β hydro-hydroxysteroid dehydrogenases (3βHSD), OCT3/4, and androgen receptor (AR) (p < 0.05). The higher dose (5 mg/kg/day) male pups exhibited more significantly affected germ cell maturation and decreased body weight. In summary, TCS-treated lactating mothers passed the deleterious effects to their untreated male pups as exhibited by reduced androgens synthesis and subsequently decreased sperm count.

Keywords: toxicology; personal care product; male reproduction; androgens; lactation

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MDPI and ACS Style

Mandal, T.K.; Parvin, N.; Joo, S.W.; Roy, P. Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats. Int. J. Environ. Res. Public Health 2020, 17, 1143. https://doi.org/10.3390/ijerph17041143

AMA Style

Mandal TK, Parvin N, Joo SW, Roy P. Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats. International Journal of Environmental Research and Public Health. 2020; 17(4):1143. https://doi.org/10.3390/ijerph17041143

Chicago/Turabian Style

Mandal, Tapas K., Nargish Parvin, Sang Woo Joo, and Partha Roy. 2020. "Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats" International Journal of Environmental Research and Public Health 17, no. 4: 1143. https://doi.org/10.3390/ijerph17041143

APA Style

Mandal, T. K., Parvin, N., Joo, S. W., & Roy, P. (2020). Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats. International Journal of Environmental Research and Public Health, 17(4), 1143. https://doi.org/10.3390/ijerph17041143

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Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats

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