Next Article in Journal
Endothelin-1 and LOX-1 as Markers of Endothelial Dysfunction in Obstructive Sleep Apnea Patients
Next Article in Special Issue
A Two-Phase Stochastic Dynamic Model for COVID-19 Mid-Term Policy Recommendations in Greece: A Pathway towards Mass Vaccination
Previous Article in Journal
Effectiveness of tDCS at Improving Recognition and Reducing False Memories in Older Adults
Previous Article in Special Issue
Value of Immunizations during the COVID-19 Emergency
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJERPH
Volume 18
Issue 3
10.3390/ijerph18031318
ijerph-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

IgM and IgG Profiles Reveal Peculiar Features of Humoral Immunity Response to SARS-CoV-2 Infection

by
Antonella De Donno
1,
Giambattista Lobreglio
2,
Alessandra Panico
1,
Tiziana Grassi
1,*,
Francesco Bagordo
1,
Maria Pia Bozzetti
1,
Serafina Massari
1,
Luisa Siculella
1,
Fabrizio Damiano
1,
Francesco Guerra
2,
Marilena Greco
2,
Michele Chicone
2,
Roberta Lazzari
2 and
Pietro Alifano
1
1
Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
2
Clinical Pathology and Microbiology Unit, Vito Fazzi General Hospital, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(3), 1318; https://doi.org/10.3390/ijerph18031318
Submission received: 30 December 2020 / Revised: 28 January 2021 / Accepted: 28 January 2021 / Published: 1 February 2021
(This article belongs to the Special Issue The COVID-19 Pandemic in Europe: Response to Challenges)
Browse Figures
Versions Notes

Abstract

The emergence of coronavirus disease 2019 (COVID-19) is globally a major healthcare threat. There is little information regarding the mechanisms and roles of the humoral response in SARS-CoV-2 infection. The aim of this study was to analyze the antibody levels (IgM and IgG) by chemiluminescence immunoassay in 54 subjects positive to SARS-CoV-2 swab test in relation to their clinical status (whether asymptomatic, pauci-symptomatic or with mild, sever or critical symptoms), the time from the symptom onset, sex, age, and comorbidities. Overall, the presence of comorbidities and the age of subjects were associated with their clinical status. The IgG concentrations were significantly higher in patients who developed critical and severe symptoms and seemed to be independent from age, sex and comorbidities. IgG titers peaked around day 60, and then began gradually to drop, decreasing by approximately 50% on the 180th day, while the IgM titers progressively decreased as early as the tenth day, but they could be detected even at later time points. Despite the small number of individuals, some peculiar characteristics of the humoral response in COVID-19 emerged. We observed a high inter-individual variability, an ephemeral IgG half-life in several patients, and a persistence of IgM in others.
Keywords: antibodies; COVID-19; humoral immunity; SARS-CoV-2 antibodies; COVID-19; humoral immunity; SARS-CoV-2
Graphical Abstract

Share and Cite

MDPI and ACS Style

De Donno, A.; Lobreglio, G.; Panico, A.; Grassi, T.; Bagordo, F.; Bozzetti, M.P.; Massari, S.; Siculella, L.; Damiano, F.; Guerra, F.; et al. IgM and IgG Profiles Reveal Peculiar Features of Humoral Immunity Response to SARS-CoV-2 Infection. Int. J. Environ. Res. Public Health 2021, 18, 1318. https://doi.org/10.3390/ijerph18031318

AMA Style

De Donno A, Lobreglio G, Panico A, Grassi T, Bagordo F, Bozzetti MP, Massari S, Siculella L, Damiano F, Guerra F, et al. IgM and IgG Profiles Reveal Peculiar Features of Humoral Immunity Response to SARS-CoV-2 Infection. International Journal of Environmental Research and Public Health. 2021; 18(3):1318. https://doi.org/10.3390/ijerph18031318

Chicago/Turabian Style

De Donno, Antonella, Giambattista Lobreglio, Alessandra Panico, Tiziana Grassi, Francesco Bagordo, Maria Pia Bozzetti, Serafina Massari, Luisa Siculella, Fabrizio Damiano, Francesco Guerra, and et al. 2021. "IgM and IgG Profiles Reveal Peculiar Features of Humoral Immunity Response to SARS-CoV-2 Infection" International Journal of Environmental Research and Public Health 18, no. 3: 1318. https://doi.org/10.3390/ijerph18031318

APA Style

De Donno, A., Lobreglio, G., Panico, A., Grassi, T., Bagordo, F., Bozzetti, M. P., Massari, S., Siculella, L., Damiano, F., Guerra, F., Greco, M., Chicone, M., Lazzari, R., & Alifano, P. (2021). IgM and IgG Profiles Reveal Peculiar Features of Humoral Immunity Response to SARS-CoV-2 Infection. International Journal of Environmental Research and Public Health, 18(3), 1318. https://doi.org/10.3390/ijerph18031318

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop