Effects of PM2.5 Exposure on the ACE/ACE2 Pathway: Possible Implication in COVID-19 Pandemic
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. PM Sources and Characterization
2.3. Dose
2.4. Intratracheal PM2.5 Instillation
2.5. Organ Homogenization
2.6. Electrophoresis and Immunoblotting
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Organ | ACE/ACE2 | ±S.E. | p |
---|---|---|---|
lung | 0.82 | ±0.087 | |
heart | 0.90 | ±0.143 | |
liver | 1.83 | ±0.187 | *** |
brain | 1.40 | ±0.127 | * |
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Botto, L.; Lonati, E.; Russo, S.; Cazzaniga, E.; Bulbarelli, A.; Palestini, P. Effects of PM2.5 Exposure on the ACE/ACE2 Pathway: Possible Implication in COVID-19 Pandemic. Int. J. Environ. Res. Public Health 2023, 20, 4393. https://doi.org/10.3390/ijerph20054393
Botto L, Lonati E, Russo S, Cazzaniga E, Bulbarelli A, Palestini P. Effects of PM2.5 Exposure on the ACE/ACE2 Pathway: Possible Implication in COVID-19 Pandemic. International Journal of Environmental Research and Public Health. 2023; 20(5):4393. https://doi.org/10.3390/ijerph20054393
Chicago/Turabian StyleBotto, Laura, Elena Lonati, Stefania Russo, Emanuela Cazzaniga, Alessandra Bulbarelli, and Paola Palestini. 2023. "Effects of PM2.5 Exposure on the ACE/ACE2 Pathway: Possible Implication in COVID-19 Pandemic" International Journal of Environmental Research and Public Health 20, no. 5: 4393. https://doi.org/10.3390/ijerph20054393