Next Article in Journal
Estimating Excess Mortality Due to Prostate, Breast, and Uterus Cancer during the COVID-19 Pandemic in Peru: A Time Series Analysis
Previous Article in Journal
A Holistic Vision of the Academic and Sports Development of Elite Spanish Track and Field Athletes
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Analysis of the Presence of the Virulence and Regulation Genes from Staphylococcus aureus (S. aureus) in Coagulase Negative Staphylococci and the Influence of the Staphylococcal Cross-Talk on Their Functions

by
Magdalena Grazul
1,*,
Ewa Balcerczak
2 and
Monika Sienkiewicz
1
1
Department of Pharmaceutical Microbiology and Microbiological Diagnostics, Medical University of Lodz, Muszynskiego 1 Street, 90-151 Lodz, Poland
2
Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1 Street, 90-151 Lodz, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2023, 20(6), 5155; https://doi.org/10.3390/ijerph20065155
Submission received: 12 February 2023 / Revised: 8 March 2023 / Accepted: 12 March 2023 / Published: 15 March 2023
(This article belongs to the Section Infectious Disease Epidemiology)

Abstract

Coagulase-negative staphylococci (CoNS) are increasingly becoming a public health issue worldwide due to their growing resistance to antibiotics and common involvement in complications related to invasive surgical procedures, and nosocomial and urinary tract infections. Their behavior either as a commensal or a pathogen is a result of strict regulation of colonization and virulence factors. Although functionality of virulence factors and processes involved in their regulation are quite well understood in S. aureus, little is known about them in CoNS species. Therefore, the aim of our studies was to check if clinical CoNS strains may contain virulence factors and genes involved in resistance to methicillin, that are homologous to S. aureus. Moreover, we checked the presence of elements responsible for regulation of genes that encode virulence factors typical for S. aureus in tested isolates. We also investigated whether the regulation factors produced by one CoNS isolate can affect virulence activity of other strains by co-incubation of tested isolates with supernatant from other isolates. Our studies confirmed the presence of virulence factor and regulatory genes attributed to S. aureus in CoNS isolates and indicated that one strain with an active agr gene is able to affect biofilm formation and δ-toxin activity of strains with inactive agr genes. The cognition of prevalence and regulation of virulence factors as well as antibiotic resistance of CoNS isolates is important for better control and treatment of CoNS infections.
Keywords: staphylococcus; genes transfer; virulence; coagulase negative; CoNS virulence staphylococcus; genes transfer; virulence; coagulase negative; CoNS virulence

Share and Cite

MDPI and ACS Style

Grazul, M.; Balcerczak, E.; Sienkiewicz, M. Analysis of the Presence of the Virulence and Regulation Genes from Staphylococcus aureus (S. aureus) in Coagulase Negative Staphylococci and the Influence of the Staphylococcal Cross-Talk on Their Functions. Int. J. Environ. Res. Public Health 2023, 20, 5155. https://doi.org/10.3390/ijerph20065155

AMA Style

Grazul M, Balcerczak E, Sienkiewicz M. Analysis of the Presence of the Virulence and Regulation Genes from Staphylococcus aureus (S. aureus) in Coagulase Negative Staphylococci and the Influence of the Staphylococcal Cross-Talk on Their Functions. International Journal of Environmental Research and Public Health. 2023; 20(6):5155. https://doi.org/10.3390/ijerph20065155

Chicago/Turabian Style

Grazul, Magdalena, Ewa Balcerczak, and Monika Sienkiewicz. 2023. "Analysis of the Presence of the Virulence and Regulation Genes from Staphylococcus aureus (S. aureus) in Coagulase Negative Staphylococci and the Influence of the Staphylococcal Cross-Talk on Their Functions" International Journal of Environmental Research and Public Health 20, no. 6: 5155. https://doi.org/10.3390/ijerph20065155

APA Style

Grazul, M., Balcerczak, E., & Sienkiewicz, M. (2023). Analysis of the Presence of the Virulence and Regulation Genes from Staphylococcus aureus (S. aureus) in Coagulase Negative Staphylococci and the Influence of the Staphylococcal Cross-Talk on Their Functions. International Journal of Environmental Research and Public Health, 20(6), 5155. https://doi.org/10.3390/ijerph20065155

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop