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Current Oncology
Volume 23
Issue 4
10.3747/co.23.3006
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Concurrent Hypopituitarism and Leukemic Retinopathy in a Child with B-Precursor Acute Lymphoblastic Leukemia and Isolated Central Nervous System Relapse

by
K.H. Wu
1,2,*,
H.P. Wu
3,4,
H.J. Lin
5,6,
C.H. Wang
7,
H.Y. Chen
8,
T. Weng
2,
C.T. Peng
2,9 and
Y.H. Chao
10,11
1
School of Post Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
2
Division of Pediatric Hematology–Oncology, Children’s Hospital, China Medical University, Taichung, Taiwan
3
Division of Pediatric General Medicine, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
4
College of Medicine, Chang Gung University, Taoyuan, Taiwan
5
Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
6
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
7
Division of Genetics and Metabolism, Children’s Hospital, China Medical University, Taichung, Taiwan
8
Department of Radiology, China Medical University Hospital, Taichung, Taiwan
9
Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
10
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
11
School of Medicine, Chung Shan Medical University, Taichung, Taiwan
 
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Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(4), 431-434; https://doi.org/10.3747/co.23.3006
Submission received: 6 May 2016 / Revised: 7 June 2016 / Accepted: 8 July 2016 / Published: 1 August 2016

Abstract

Hypopituitarism in leukemia is very rare. In addition, central nervous system (cns) relapse and leukemic retinopathy in childhood acute lymphoblastic leukemia (all) have declined with the use of modern systemic chemotherapy that includes cns prophylaxis. Here, we report the case of a 4-year-old girl who received chemotherapy and intrathecal therapy without cns radiation after a diagnosis of B-precursor all without cns involvement. Three months after chemotherapy completion, she presented with lower-extremity weakness and was diagnosed with an isolated cns relapse. Concurrent hypopituitarism and leukemic retinopathy were also found. After receiving craniospinal radiotherapy and systemic chemotherapy, her retinopathy and vision improved. She is now in complete remission, and she is still on chemotherapy according to the guideline from the Pediatric Oncology Group. Although rare, hypopituitarism and leukemic retinopathy should be taken into consideration in patients with cns involvement by leukemia.
Keywords: hypopituitarism; retinopathy; acute lymphoblastic leukemia; central nervous system relapse hypopituitarism; retinopathy; acute lymphoblastic leukemia; central nervous system relapse

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MDPI and ACS Style

Wu, K.H.; Wu, H.P.; Lin, H.J.; Wang, C.H.; Chen, H.Y.; Weng, T.; Peng, C.T.; Chao, Y.H. Concurrent Hypopituitarism and Leukemic Retinopathy in a Child with B-Precursor Acute Lymphoblastic Leukemia and Isolated Central Nervous System Relapse. Curr. Oncol. 2016, 23, 431-434. https://doi.org/10.3747/co.23.3006

AMA Style

Wu KH, Wu HP, Lin HJ, Wang CH, Chen HY, Weng T, Peng CT, Chao YH. Concurrent Hypopituitarism and Leukemic Retinopathy in a Child with B-Precursor Acute Lymphoblastic Leukemia and Isolated Central Nervous System Relapse. Current Oncology. 2016; 23(4):431-434. https://doi.org/10.3747/co.23.3006

Chicago/Turabian Style

Wu, K.H., H.P. Wu, H.J. Lin, C.H. Wang, H.Y. Chen, T. Weng, C.T. Peng, and Y.H. Chao. 2016. "Concurrent Hypopituitarism and Leukemic Retinopathy in a Child with B-Precursor Acute Lymphoblastic Leukemia and Isolated Central Nervous System Relapse" Current Oncology 23, no. 4: 431-434. https://doi.org/10.3747/co.23.3006

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