Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery

Gilpin, Victoria; Surandhiran, Deetchaya; Scott, Cameron; Devine, Amy; Cundell, Jill H.; Gill, Chris I. R.; Pourshahidi, L. Kirsty; Davis, James

doi:10.3390/mi13071132

Open AccessFeature PaperEditor’s ChoiceArticle

Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery

by

Victoria Gilpin

¹

,

Deetchaya Surandhiran

¹

,

Cameron Scott

¹,

Amy Devine

¹,

Jill H. Cundell

²,

Chris I. R. Gill

³,

L. Kirsty Pourshahidi

³

and

James Davis

^1,*

¹

School of Engineering, Ulster University, Jordanstown BT37 0QB, Northern Ireland, UK

²

School of Health Sciences, Ulster University, Jordanstown BT37 0QB, Northern Ireland, UK

³

School of Biomolecular Sciences, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK

^*

Author to whom correspondence should be addressed.

Micromachines 2022, 13(7), 1132; https://doi.org/10.3390/mi13071132

Submission received: 30 June 2022 / Revised: 13 July 2022 / Accepted: 15 July 2022 / Published: 18 July 2022

(This article belongs to the Special Issue Biohybrid Technologies: From Materials Manufacturing to Biomedical Application)

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Abstract

The combination of paraffin wax and O,O′-bis(2-aminopropyl) polypropylene glycol–block–polyethylene glycol–block–polypropylene glycol was used as a phase-change material (PCM) for the controlled delivery of curcumin. The PCM was combined with a graphene-based heater derived from the laser scribing of polyimide film. This assembly provides a new approach to a smart patch through which release can be electronically controlled, allowing repetitive dosing. Rather than relying on passive diffusion, delivery is induced and terminated through the controlled heating of the PCM with transfer only occurring when the PCM transitions from solid to liquid. The material properties of the device and release characteristics of the strategy under repetitive dosing are critically assessed. The delivery yield of curcumin was found to be 3.5 µg (4.5 µg/cm²) per 3 min thermal cycle.

Keywords: curcumin; phase-change material; drug delivery; thermal activation; smart patch; laser-induced graphene (LIG)

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MDPI and ACS Style

Gilpin, V.; Surandhiran, D.; Scott, C.; Devine, A.; Cundell, J.H.; Gill, C.I.R.; Pourshahidi, L.K.; Davis, J. Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery. Micromachines 2022, 13, 1132. https://doi.org/10.3390/mi13071132

AMA Style

Gilpin V, Surandhiran D, Scott C, Devine A, Cundell JH, Gill CIR, Pourshahidi LK, Davis J. Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery. Micromachines. 2022; 13(7):1132. https://doi.org/10.3390/mi13071132

Chicago/Turabian Style

Gilpin, Victoria, Deetchaya Surandhiran, Cameron Scott, Amy Devine, Jill H. Cundell, Chris I. R. Gill, L. Kirsty Pourshahidi, and James Davis. 2022. "Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery" Micromachines 13, no. 7: 1132. https://doi.org/10.3390/mi13071132

APA Style

Gilpin, V., Surandhiran, D., Scott, C., Devine, A., Cundell, J. H., Gill, C. I. R., Pourshahidi, L. K., & Davis, J. (2022). Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery. Micromachines, 13(7), 1132. https://doi.org/10.3390/mi13071132

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Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery

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