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Article

Oxidative Stress and Free Radical Processes in Tumor and Non-Tumor Obstructive Jaundice: Influence of Disease Duration, Severity and Surgical Treatment on Outcomes

by
Ekaterina Vladimirovna Silina
1,*,†,
Victor Alexandrovich Stupin
2,†,
Igor Sergeevich Abramov
2,
Sergey Brankovich Bolevich
1,
Gouri Deshpande
3,4,
Raghu Ram Achar
3 and
Tatiana Georgievna Sinelnikova
1
1
Department of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
2
Department of Hospital Surgery No. 1, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, Russia
3
Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570 015, India
4
Department of Biochemisty, Karnatak University, Dharwad 580 003, India
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pathophysiology 2022, 29(1), 32-51; https://doi.org/10.3390/pathophysiology29010005
Submission received: 11 November 2021 / Revised: 25 January 2022 / Accepted: 27 January 2022 / Published: 31 January 2022
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Abstract

The aim of this study was to assess the patterns and pattern disruptions of free radical processes in patients with obstructive jaundice of various origins, and the severity of jaundice before and after decompression. Oxidative stress markers were determined in 128 patients with obstructive jaundice with a tumor genesis (23.4%) or non-tumor genesis (76.6%). The patients were hospitalized at different stages of clinical signs of jaundice. We studied the anti-peroxide activity in plasma, basal and stimulated indicators of the chemiluminescence intensity in leukocytes, leukocyte activity coefficients reflecting the level of reactive oxygen species generated by leukocytes, malondialdehyde levels indicative of the degree of lipid peroxidation and cellular destruction, liver enzymes (markers of cytolysis) and bilirubin levels. Data for hepatocyte death and markers of oxidative stress correlated with the severity of jaundice, its duration and the method of its surgical correction. It is proposed that using markers of free radical processes to assess the prognosis and effectiveness of treatment and to personalize treatment measures will improve the results of jaundice treatment.
Keywords: free radical processes; obstructive jaundice; tumor jaundice; non-tumor jaundice; oxidative stress; reactive oxygen species; malondialdehyde; markers of severity; prognosis free radical processes; obstructive jaundice; tumor jaundice; non-tumor jaundice; oxidative stress; reactive oxygen species; malondialdehyde; markers of severity; prognosis

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MDPI and ACS Style

Silina, E.V.; Stupin, V.A.; Abramov, I.S.; Bolevich, S.B.; Deshpande, G.; Achar, R.R.; Sinelnikova, T.G. Oxidative Stress and Free Radical Processes in Tumor and Non-Tumor Obstructive Jaundice: Influence of Disease Duration, Severity and Surgical Treatment on Outcomes. Pathophysiology 2022, 29, 32-51. https://doi.org/10.3390/pathophysiology29010005

AMA Style

Silina EV, Stupin VA, Abramov IS, Bolevich SB, Deshpande G, Achar RR, Sinelnikova TG. Oxidative Stress and Free Radical Processes in Tumor and Non-Tumor Obstructive Jaundice: Influence of Disease Duration, Severity and Surgical Treatment on Outcomes. Pathophysiology. 2022; 29(1):32-51. https://doi.org/10.3390/pathophysiology29010005

Chicago/Turabian Style

Silina, Ekaterina Vladimirovna, Victor Alexandrovich Stupin, Igor Sergeevich Abramov, Sergey Brankovich Bolevich, Gouri Deshpande, Raghu Ram Achar, and Tatiana Georgievna Sinelnikova. 2022. "Oxidative Stress and Free Radical Processes in Tumor and Non-Tumor Obstructive Jaundice: Influence of Disease Duration, Severity and Surgical Treatment on Outcomes" Pathophysiology 29, no. 1: 32-51. https://doi.org/10.3390/pathophysiology29010005

APA Style

Silina, E. V., Stupin, V. A., Abramov, I. S., Bolevich, S. B., Deshpande, G., Achar, R. R., & Sinelnikova, T. G. (2022). Oxidative Stress and Free Radical Processes in Tumor and Non-Tumor Obstructive Jaundice: Influence of Disease Duration, Severity and Surgical Treatment on Outcomes. Pathophysiology, 29(1), 32-51. https://doi.org/10.3390/pathophysiology29010005

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