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Article
Peer-Review Record

The Incidence, Survival, and HPV Impact of Second Primary Cancer following Primary Oropharyngeal Squamous Cell Carcinoma: A 20-Year Retrospective and Population-Based Study

Viruses 2023, 15(1), 34; https://doi.org/10.3390/v15010034
by Lasse Andersen 1,*,†, Kathrine Kronberg Jakobsen 1,*,†, Amanda-Louise Fenger Carlander 1, Martin Garset-Zamani 1, Jeppe Friborg 2, Katalin Kiss 3, Rasmus L. Marvig 4, Caroline Olsen 3, Finn Cilius Nielsen 4, Elo Andersen 2, Christian Grønhøj 1 and Christian von Buchwald 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Viruses 2023, 15(1), 34; https://doi.org/10.3390/v15010034
Submission received: 2 December 2022 / Revised: 17 December 2022 / Accepted: 18 December 2022 / Published: 22 December 2022
(This article belongs to the Special Issue HPV in the Head and Neck Region 2.0)

Round 1

Reviewer 1 Report

Dear Authors,

You present here a retrospective study regarding the incidence, survival and HPV impact of second cancer following primary oropharingeal cancer. The paper is well written and organized, with just minor English mistakes. 

I suggest you add the drugs used in chemotherapy and if there were differences  regarding the development of second cancer in relationship with the chemotherapy used.

Plus, I suggest you investigate more the data regarding the survival of the patients and what were the medical protocols used (chemotherapy, radiotherapy). 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The paper idea is novel and contributes well to the scientific community. I congratulate the authors on producing an extensive master piece of big data over 20 years.

The statistical powers used are great but the results must be clearly discussed. There are a lot of graphs and tables and the results are only presented the same way as in the Tables and Figures. The statistical inference should be properly explained.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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