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Viruses, Volume 16, Issue 12

December 2024 - 164 articles

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Cover Story: Herpes simplex virus type 1 (HSV-1) acyclovir (ACV) resistance is acquired by mutations in the viral thymidine kinase (TK) or DNA polymerase (DNApol) genes. In our previous study, in order to analyze the mutations responsible for ACV resistance using recombinant HSV-1 BAC, we obtained a HSV-1 clone that was resistant to ACV without having any mutations in the TK and DNApol genes. We extended the study of the resistant HSV-1 clone by deploying next-generation full-genome sequencing and identified a single nucleotide substitution in the UL29 gene, resulting P597L amino acid mutation in the ICP8 protein. The mutant HSV-1, constructed by introducing the P597L mutation of ICP8 protein in the original HSV-1 BAC, was also resistant to ACV. These results indicated that ICP8 might be involved in the mechanism of action of anti-herpesvirus drugs against HSV-1. View this paper

Articles (164)

  • Article
  • Open Access
4 Citations
2,070 Views
15 Pages

Epidemiological and Molecular Investigation of Feline Panleukopenia Virus Infection in China

  • Yinghui Wen,
  • Zhengxu Tang,
  • Kunli Wang,
  • Zhengyang Geng,
  • Simin Yang,
  • Junqing Guo,
  • Yongzhen Chen,
  • Jiankun Wang,
  • Zhiyu Fan and
  • Pengju Chen
  • + 1 author

23 December 2024

The feline panleukopenia virus (FPV) is a highly contagious virus that affects cats worldwide, characterized by leukopenia, high temperature and diarrhea. Recently, the continuous prevalence and variation of FPV have attracted widespread concern. The...

  • Review
  • Open Access
7 Citations
5,389 Views
39 Pages

23 December 2024

Avian reoviruses (ARVs) represent a significant economic burden on the poultry industry due to their widespread prevalence and potential pathogenicity. These viruses, capable of infecting a diverse range of avian species, can lead to a variety of cli...

  • Review
  • Open Access
4 Citations
3,090 Views
28 Pages

Viral Oncogenesis: Synergistic Role of Genome Integration and Persistence

  • Simone La Frazia,
  • Silvia Pauciullo,
  • Verdiana Zulian and
  • Anna Rosa Garbuglia

23 December 2024

Persistence is a strategy used by many viruses to evade eradication by the immune system, ensuring their permanence and transmission within the host and optimizing viral fitness. During persistence, viruses can trigger various phenomena, including ta...

  • Article
  • Open Access
1 Citations
1,617 Views
14 Pages

A Subunit Vaccine Harboring the Fusion Capsid Proteins of Porcine Circovirus Types 2, 3, and 4 Induces Protective Immune Responses in a Mouse Model

  • Qikai Wang,
  • Ran Zhang,
  • Yue Wang,
  • Ying Wang,
  • Libin Liang,
  • Haili Ma,
  • Haidong Wang,
  • Longlong Si and
  • Xingchen Wu

23 December 2024

Coinfections with porcine circovirus types 2, 3, and 4 (PCV2, PCV3, and PCV4) are increasingly being detected in the swine industry. However, there is no commercially available vaccine which prevents coinfection with PCV2, PCV3, and PCV4. The develop...

  • Case Report
  • Open Access
4 Citations
2,064 Views
9 Pages

Investigation of an Outbreak of Equine Herpesvirus-1 Myeloencephalopathy in a Population of Aged Working Equids

  • Nicola Pusterla,
  • Kaila Lawton,
  • Samantha Barnum,
  • Kelly Ross and
  • Kris Purcell

21 December 2024

The objective of this study was to describe an outbreak of equine herpesvirus-1 myeloencephalopathy (EHM) in a population of aged equids. The outbreak was linked to the introduction of five healthy non-resident horses 15 days prior to the first case...

  • Case Report
  • Open Access
1,688 Views
8 Pages

SARS-CoV-2 Infection of the Central Nervous System: A Case Report

  • Trifon Valkov,
  • Radka Argirova and
  • George Dimitrov

21 December 2024

Central nervous system (CNS) infections caused by SARS-CoV-2 are uncommon. This case report describes the clinical progression of a 92-year-old female who developed a persistent neuroinfection associated with SARS-CoV-2. The patient initially present...

  • Article
  • Open Access
1 Citations
1,480 Views
15 Pages

Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection

  • Stefan Weinberger,
  • Carmen Stecher,
  • Marie-Theres Kastner,
  • Sergei Nekhai and
  • Christoph Steininger

21 December 2024

Protein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain u...

  • Article
  • Open Access
2 Citations
1,138 Views
15 Pages

20 December 2024

Among the cultivated crop species, the economically and culturally important grapevine plays host to the greatest number of distinctly characterized viruses. A critical component of the management and containment of these viral diseases in grapevine...

  • Article
  • Open Access
1 Citations
1,183 Views
11 Pages

Plasma Interleukin-35 Levels Predict the Prognosis in Patients with HBV-Related Acute-on-Chronic Liver Failure

  • Liujuan Ji,
  • Xue Mei,
  • Wei Yuan,
  • Hongying Guo,
  • Yuyi Zhang,
  • Zhengguo Zhang,
  • Ying Zou,
  • Yu Liu,
  • Hui Zhu and
  • Zhiping Qian
  • + 1 author

20 December 2024

This study aimed to investigate the impact of IL-35 on the prognosis of patients with HBV-ACLF. We recruited 69 patients with HBV-ACLF, 20 patients with chronic hepatitis B (CHB), 17 patients with liver cirrhosis (LC), and 20 healthy controls (HCs) f...

  • Article
  • Open Access
1,258 Views
13 Pages

Postural Abnormalities in Children with Congenital Zika Syndrome-Related Neurological and Visual Impairment

  • Raíne Borba,
  • Amanda Rodrigues,
  • Camila V. Ventura,
  • Cláudia Marques,
  • Lucélia Nóbrega,
  • Taciana Higino,
  • Dalmir Santos,
  • Juliana Sallum and
  • Liana O. Ventura

20 December 2024

Deformities, body asymmetries, and muscle contractures are common consequences of atypical postural patterns in children with c ongenital Zika syndrome (CZS). This study aimed to evaluate the posture of children with CZS, considering their neurologic...

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Viruses - ISSN 1999-4915Creative Common CC BY license