Film-Forming Systems for Dermal Drug Delivery
Abstract
:1. Introduction
1.1. Skin
1.2. Skin Anatomy
1.3. Biochemistry of the Stratum Corneum
1.4. Transdermal Transport
1.5. Dermal Systems
1.6. Transdermal Systems
2. Film-Forming Systems
2.1. Components of Film-Forming Systems
2.1.1. Drug
2.1.2. Polymer
2.1.3. Solvent
2.1.4. Plasticizer
2.2. Film-Forming Systems on the Market
Ingrediencies | Axiron® | Lamisil Once® | Hansaplast® Sprühpflaster |
---|---|---|---|
Formulation | Solution | Solution | Solution |
Drug | Testosterone | Terbinafine HCl | - |
Polymer | Polyvinylpyrrolidone | Poly(acrylamide-co-isooctylacrylat), Hydroxypropylcellulose | Acrylic copolymer, polyurethane polymer |
Solvent | Ethanol 96%, Isopropyl alcohol | Ethanol | Ethanol, water, dimethylether |
Plasticizer | Medium chain triglyceride | ||
other | Octisalate (UV protection) | ||
Application | Apply once a day to one axilla only | Single application of 2 g solution, drying time 1–2 min | Spray on a thin film of the plaster spray from a distance of 5–10 cm and allow to dry for 1 min. |
Company | Eli Lilly | GlaxoSmithKlineConsumer Healthcare | Beiersdorf |
Company | Product | Formulation |
---|---|---|
Epinamics | Liqui-Patch® | Film-forming spray |
MedPharm | MedSpray® | Film-forming spray |
Crescita Therapeutics™ | Durapeel | Film-forming emulsion |
3. Development and Investigation of Film-Forming Systems
3.1. Film-Forming Solutions
3.2. Film-Forming-Gels
3.3. Film-Forming Emulsions
4. Conclusions and Further Prospects
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Polymer | Properties |
---|---|
Polymer | Properties |
Carbopol (polyacrylat) | water-soluble, pH sensitive |
Chitosan (Poly-D-Glucosamin) | water-soluble at pH < 7 |
Crosslinked polymer layer XPL | adhesive, elastic |
Dermacryl 79 (Carboxylates Ac rylpolymer) | water-insoluble |
Ethylcellulose | non-toxic, not irritating, anti-allergic |
Eudragit NE (ethylacrylate methylmethacrylate copolymer) | water-insoluble, transparent, elastic, adhesive |
Eudragit RL-100 (polymethacrylate polymere) | water-insoluble, transparent, elastic, adhesive |
Eudragit RS-100 (polymethacrylate polymere) | water-insoluble, transparent, elastic, adhesive |
Eudragit L30D-55 (methacrylate-ethylacrylate-copolymer) | water dispersible at pH 2–3 |
Hydroxypropyl-beta-cyclodextrin | water-insoluble, increases bioavailability |
Hydroxypropylmethylcellulose (HPMC) | water-soluble, non-ionic |
KIucel (Hydroxypropyl cellulose) | water-soluble, non-ionic |
Macrogol | water-soluble |
Methyl cellulose | water-soluble |
Poloxamer (polyethylenepolypropylene glycol) | thermoreversible |
Plastoid (Butyl methacrylate-methylmethacrylate copolymer) | water-insoluble |
Polydimethylsiloxane (PDMS) | water-insoluble, non-toxic |
Polyvinyl alcohol (PVA) | water-soluble, adhesive, non-toxic |
Polyvinyl pyrrolidine (PVP) | water-soluble, adhesive, increase bioavailability |
Quaternary polymethacrylat (QPM) | water-insoluble |
Sepineo P600 (acrylamide/sodium acryloldimethyltaurate) | water-insoluble |
Silicone | water-soluble, non-occlusive |
Solvent | Properties |
---|---|
Benzyl alcohole | lipophilic, organic solvent |
Butanol | organic solvent |
Ethanol | organic solvent, volatile, hydrophil |
Ethylacetat | organic solvent, lipophilic |
Isopropanol | organic solvent, volatile, hydrophilic |
Isopropyl myristat | organic solvent, lipophilic, penetration enhancer |
Polyethylene glycole | hydrophilic, penetration enhancer |
Water | hydrophilic |
Plasticizer | Properties | Polymer | Concentration in % |
---|---|---|---|
Dibutylphthalat | Plasticizer | Eudragit E 100, Ethyl cellulose, Polyvinylpyrollidone, Hydroxypropyl methyl cellulose, | 10–40 |
Glycerol | Plasticizer | Polyvinyl Alcohol, Polyvinylpyrrolidone | 10–30 |
Polyethylenglycol 300 or 400 | Plasticizer | Hydroxypropyl cellulose, Eudragit E 100, Carbopol, | 5 |
Polysorbat 80 | Non-ionic solubilizer, plasticizer, emulsifier, co-emulsifier | Cellulose Acetate | 20–50 |
Propylene glycol | Polymeric solubilizer, plasticizer | Polyvinyl Alcohol, Polyvinylpyrrolidone, Eudragit L100, Hydroxypropyl methyl cellulose, Ethylcellulose, Carboxy methyl cellulose | 5–50 |
Sorbitol | Plasticizer | Polyvinyl Alcohol, Chitosan | 2–20 |
Triacetin | Versatile water or oil miscible solvent. plasticizer | Eudragit E 100 | 1.43–5.48 |
Triethyl citrate | Plasticizer | Hydroxypropyl methyl cellulose, Eudragit RL and NE, Acrylate copolymer, Polyvinylpyrrolidone, Polyvinyl Alcohol | 6 |
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Pünnel, L.C.; Lunter, D.J. Film-Forming Systems for Dermal Drug Delivery. Pharmaceutics 2021, 13, 932. https://doi.org/10.3390/pharmaceutics13070932
Pünnel LC, Lunter DJ. Film-Forming Systems for Dermal Drug Delivery. Pharmaceutics. 2021; 13(7):932. https://doi.org/10.3390/pharmaceutics13070932
Chicago/Turabian StylePünnel, Larissa Carine, and Dominique Jasmin Lunter. 2021. "Film-Forming Systems for Dermal Drug Delivery" Pharmaceutics 13, no. 7: 932. https://doi.org/10.3390/pharmaceutics13070932
APA StylePünnel, L. C., & Lunter, D. J. (2021). Film-Forming Systems for Dermal Drug Delivery. Pharmaceutics, 13(7), 932. https://doi.org/10.3390/pharmaceutics13070932