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Volume 13
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10.3390/pharmaceutics13081300
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Article

Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma

by
Luca Casula
1,
Francesco Lai
1,
Elena Pini
2,
Donatella Valenti
1,
Chiara Sinico
1,
Maria Cristina Cardia
1,
Salvatore Marceddu
3,
Giorgia Ailuno
4 and
Anna Maria Fadda
1,*
1
Dipartimento di Scienze della Vita e dell’Ambiente, Sezione di Scienze del Farmaco, Università degli Studi di Cagliari, 09124 Cagliari, Italy
2
DISFARM, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy
3
Istituto di Scienze delle Produzioni Alimentari (ISPA)-CNR, Sez. di Sassari, 07040 Baldinca, Italy
4
Department of Pharmacy, University of Genova, 16147 Genova, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2021, 13(8), 1300; https://doi.org/10.3390/pharmaceutics13081300
Submission received: 21 July 2021 / Revised: 16 August 2021 / Accepted: 18 August 2021 / Published: 20 August 2021
(This article belongs to the Special Issue Pharmaceutics and Drug Delivery in Italy)
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Abstract

Curcumin has shown a potential extraordinary activity as an add-on ingredient in asthma treatment, due to its immunomodulatory and anti-inflammatory mechanism of action. However, its low water solubility and bioavailability lead to a poor therapeutic effect, which can be overcome by its formulation as nanocrystals. The aim of this study was to prepare a multicomponent formulation for the delivery of curcumin (CUR) and beclomethasone dipropionate (BDP) into the lungs as water-based nanosuspensions (NS). Single component formulations (CUR-NS, BDP-NS) and a multicomponent formulation (CUR+BDP-NS) were prepared through a wet ball media milling technique, using P188 as a non-toxic stabilizer. Characterization was carried out in terms of size, size distribution, zeta potential, nanocrystals morphology, and solid-state properties. Moreover, the inhalation delivery efficiency was studied with Next Generation Impactor (NGI, Apparatus E Ph. Eu). CUR-NS was optimized and showed a long-term stability and improved nanocrystals apparent solubility. The three formulations exhibited a nanocrystal mean diameter in the range of 200–240 nm and a homogenous particle size distribution. Aggregation or sedimentation phenomena were not observed in the multicomponent formulation on 90 days storage at room temperature. Finally, the nebulization tests of the three samples showed optimal aerodynamic parameters and MMAD < 5 µm.
Keywords: curcumin; beclomethasone dipropionate; nanosuspension; asthma; pulmonary delivery; NGI; DSC; XRPD; ATR-FTIR curcumin; beclomethasone dipropionate; nanosuspension; asthma; pulmonary delivery; NGI; DSC; XRPD; ATR-FTIR
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MDPI and ACS Style

Casula, L.; Lai, F.; Pini, E.; Valenti, D.; Sinico, C.; Cardia, M.C.; Marceddu, S.; Ailuno, G.; Fadda, A.M. Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma. Pharmaceutics 2021, 13, 1300. https://doi.org/10.3390/pharmaceutics13081300

AMA Style

Casula L, Lai F, Pini E, Valenti D, Sinico C, Cardia MC, Marceddu S, Ailuno G, Fadda AM. Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma. Pharmaceutics. 2021; 13(8):1300. https://doi.org/10.3390/pharmaceutics13081300

Chicago/Turabian Style

Casula, Luca, Francesco Lai, Elena Pini, Donatella Valenti, Chiara Sinico, Maria Cristina Cardia, Salvatore Marceddu, Giorgia Ailuno, and Anna Maria Fadda. 2021. "Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma" Pharmaceutics 13, no. 8: 1300. https://doi.org/10.3390/pharmaceutics13081300

APA Style

Casula, L., Lai, F., Pini, E., Valenti, D., Sinico, C., Cardia, M. C., Marceddu, S., Ailuno, G., & Fadda, A. M. (2021). Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma. Pharmaceutics, 13(8), 1300. https://doi.org/10.3390/pharmaceutics13081300

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