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Volume 14
Issue 11
10.3390/pharmaceutics14112316
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Review

Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections

by
Ellen Wasan
1,
Tavonga Mandava
1,
Pablo Crespo-Moran
1,
Adrienne Nagy
1 and
Kishor M. Wasan
2,*
1
College of Pharmacy and Nutrition, University of Saskatchewan, Health Sciences Building, Saskatoon, SK S7N 5E5, Canada
2
Department of Urologic Sciences, Faculty of Medicine & the Neglected Global Diseases Initiative, University of British Columbia, Vancouver Campus, Vancouver, BC V5Z 1L8, Canada
*
Author to whom correspondence should be addressed.
Pharmaceutics 2022, 14(11), 2316; https://doi.org/10.3390/pharmaceutics14112316
Submission received: 14 September 2022 / Revised: 19 October 2022 / Accepted: 24 October 2022 / Published: 28 October 2022
(This article belongs to the Special Issue Development of Novel Pharmaceuticals for the Treatment of Parasitic Diseases)
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Abstract

Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-borne parasitic and fungal infections. However, its use, particularly in the developing world, has been limited by dose-dependent kidney toxicity, other systemic-related toxicity issues following injection, the inconvenience of parenteral administration, and accessibility. Oral formulation approaches have focused on the dual problem of solubility and permeability of AmpB, which is poorly water soluble, amphoteric and has extremely low oral bioavailability. Therefore, to enhance oral absorption, researchers have employed micellar formulations, polymeric nanoparticles, cochleates, pro-drugs, and self-emulsifying drug delivery systems (SEDDS). This paper will highlight current uses of AmpB against parasitic infections such as leishmaniasis, preclinical and clinical formulation strategies, applications in veterinary medicine and the importance of developing a cost-effective and safe oral AmpB formulation.
Keywords: oral amphotericin B; safety and tolerability; pharmacokinetics; parasitic infections; human use; veterinary use; nanomedicines; drug delivery; nanoparticles; SEDDS oral amphotericin B; safety and tolerability; pharmacokinetics; parasitic infections; human use; veterinary use; nanomedicines; drug delivery; nanoparticles; SEDDS

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MDPI and ACS Style

Wasan, E.; Mandava, T.; Crespo-Moran, P.; Nagy, A.; Wasan, K.M. Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections. Pharmaceutics 2022, 14, 2316. https://doi.org/10.3390/pharmaceutics14112316

AMA Style

Wasan E, Mandava T, Crespo-Moran P, Nagy A, Wasan KM. Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections. Pharmaceutics. 2022; 14(11):2316. https://doi.org/10.3390/pharmaceutics14112316

Chicago/Turabian Style

Wasan, Ellen, Tavonga Mandava, Pablo Crespo-Moran, Adrienne Nagy, and Kishor M. Wasan. 2022. "Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections" Pharmaceutics 14, no. 11: 2316. https://doi.org/10.3390/pharmaceutics14112316

APA Style

Wasan, E., Mandava, T., Crespo-Moran, P., Nagy, A., & Wasan, K. M. (2022). Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections. Pharmaceutics, 14(11), 2316. https://doi.org/10.3390/pharmaceutics14112316

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