PLGA-Gold Nanocomposite: Preparation and Biomedical Applications
Abstract
:1. Introduction
- (1)
- Discuss the outstanding properties of gold nanoprobes to justify their use;
- (2)
- Discuss current available methods for gold nanoprobe’s surface functionalization and subsequent encapsulation into polymeric carriers;
- (3)
- Provide examples from the research work of our own and other groups on how labeling with gold nanoprobes allows for the precise tracking, visualization and quantification of pharmaceutical polymeric nanocarriers as well as the fabrication of laser-responsive drug delivery systems as summarized in Figure 1.
2. Brilliant Optical Extinction of Encapsulated GNP Enables Outstanding Sensing and Tracking Capabilities
3. Gold Nanoprobes Enables Electron Microscopy-Based High Spatial Resolution Imaging
4. Gold Nanoprobes Enables Computed Tomography Imaging
5. Gold Nanoprobes Enable Mass Spectrometry-Based Quantification
6. Labeling Polymeric Nanocarriers with Gold Nanoprobes as Raman Active Tags
7. Encapsulation Approaches and Surface Functionalization of Gold Nanoparticles
8. Doping Polymeric Nanotherapeutics with NIR-Absorbing Gold Nanoparticles: Novel Drug Delivery Systems
9. Concluding Remarks and Future Directions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Emulsion-Evaporation | Nanoprecipitation |
---|---|
Longer and more complex process | Shorter and simpler process |
Requires mechanical emulsification to form a stable emulsion | Simple mixing |
GNP can be hydrophilic (w/o/w emulsion) or hydrophobic (o/w) | GNP should be hydrophobic |
Hydrophobic GNP should be dissolved in immiscible organic solvents (DCM, chloroform ethyl acetate) | Hydrophobic GNP should be dissolved in miscible organic solvents (acetone, DMSO, DMF, THF) |
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Alkilany, A.M.; Rachid, O.; Alkawareek, M.Y.; Billa, N.; Daou, A.; Murphy, C.J. PLGA-Gold Nanocomposite: Preparation and Biomedical Applications. Pharmaceutics 2022, 14, 660. https://doi.org/10.3390/pharmaceutics14030660
Alkilany AM, Rachid O, Alkawareek MY, Billa N, Daou A, Murphy CJ. PLGA-Gold Nanocomposite: Preparation and Biomedical Applications. Pharmaceutics. 2022; 14(3):660. https://doi.org/10.3390/pharmaceutics14030660
Chicago/Turabian StyleAlkilany, Alaaldin M., Ousama Rachid, Mahmoud Y. Alkawareek, Nashiru Billa, Anis Daou, and Catherine J. Murphy. 2022. "PLGA-Gold Nanocomposite: Preparation and Biomedical Applications" Pharmaceutics 14, no. 3: 660. https://doi.org/10.3390/pharmaceutics14030660