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Article

Focal Photocoagulation as an Adjunctive Therapy to Reduce the Burden of Intravitreal Injections in Macula Edema Patients, the LyoMAC2 Study

by
Lucas Séjournet
1,2,*,
Laurent Kodjikian
2,3,
Sandra Elbany
4,
Benoit Allignet
5,6,
Emilie Agard
1,
Mayeul Chaperon
2,
Jérémy Billant
1,
Philippe Denis
2,
Thibaud Mathis
2,
Carole Burillon
4 and
Corinne Dot
1,7
1
Department of Ophthalmology, Desgenettes Military Hospital, 69003 Lyon, France
2
Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
3
Centre de Recherche Clinique, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
4
Department of Ophthalmology, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69003 Lyon, France
5
Department of Radiation Oncology, Centre Léon Bérard, 28 rue Laennec, 69673 Lyon, France
6
CREATIS, CNRS UMR 5220, Inserm U1206, INSA-Lyon, Université Jean Monnet Saint-Étienne, Université Claude Bernard Lyon 1, 69621 Villeurbanne, France
7
French Military Academy of Val de Grace, 75005 Paris, France
*
Author to whom correspondence should be addressed.
Pharmaceutics 2023, 15(2), 308; https://doi.org/10.3390/pharmaceutics15020308
Submission received: 25 November 2022 / Revised: 6 January 2023 / Accepted: 13 January 2023 / Published: 17 January 2023
(This article belongs to the Special Issue Drugs and Drug Delivery for Diabetes Mellitus Treatment)
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Abstract

Aim: To assess the efficacy of focal photocoagulation of capillary macroaneurysms (CMA) to reduce the burden of intravitreal injections (IVI) in patients with macular edema (ME). Materials and Methods: Retrospective multicenter study in patients with diabetic ME or ME secondary to retinal vein occlusion (ME-RVO). CMA associated with ME were selectively photocoagulated. Patients were followed for one year after photocoagulation. Results: 93 eyes of 76 patients were included in this study. At 6 months after the laser (n = 93), there was a significant decrease in mean macular thickness (from 354 µm to 314 µm, p < 0.001) and in mean IVI number (from 2.52 to 1.52 at 6 months, p < 0.001). The mean BCVA remained stable (0.32 and 0.31 logMAR at baseline and 6 months, p = 0.95). At 12 months (n = 81/93), there was a significant decrease in mean macular thickness (from 354 µm to 314 µm, p < 0.001) and in mean IVI number (from 4.44 to 2.95 at 12 months, p < 0.001), while the mean BCVA remained stable (0.32 and 0.30 logMAR at baseline and 12 months, p = 0.16). Conclusion: Focal laser photocoagulation of CMA seems to be effective and safe for reducing the burden of IVI in patients with ME. Their screening during the follow-up should be considered closely.
Keywords: macular edema; capillary macroaneurysms; telangiectatic capillaries; diabetic macular edema; retinal vein occlusion; focal laser photocoagulation macular edema; capillary macroaneurysms; telangiectatic capillaries; diabetic macular edema; retinal vein occlusion; focal laser photocoagulation

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MDPI and ACS Style

Séjournet, L.; Kodjikian, L.; Elbany, S.; Allignet, B.; Agard, E.; Chaperon, M.; Billant, J.; Denis, P.; Mathis, T.; Burillon, C.; et al. Focal Photocoagulation as an Adjunctive Therapy to Reduce the Burden of Intravitreal Injections in Macula Edema Patients, the LyoMAC2 Study. Pharmaceutics 2023, 15, 308. https://doi.org/10.3390/pharmaceutics15020308

AMA Style

Séjournet L, Kodjikian L, Elbany S, Allignet B, Agard E, Chaperon M, Billant J, Denis P, Mathis T, Burillon C, et al. Focal Photocoagulation as an Adjunctive Therapy to Reduce the Burden of Intravitreal Injections in Macula Edema Patients, the LyoMAC2 Study. Pharmaceutics. 2023; 15(2):308. https://doi.org/10.3390/pharmaceutics15020308

Chicago/Turabian Style

Séjournet, Lucas, Laurent Kodjikian, Sandra Elbany, Benoit Allignet, Emilie Agard, Mayeul Chaperon, Jérémy Billant, Philippe Denis, Thibaud Mathis, Carole Burillon, and et al. 2023. "Focal Photocoagulation as an Adjunctive Therapy to Reduce the Burden of Intravitreal Injections in Macula Edema Patients, the LyoMAC2 Study" Pharmaceutics 15, no. 2: 308. https://doi.org/10.3390/pharmaceutics15020308

APA Style

Séjournet, L., Kodjikian, L., Elbany, S., Allignet, B., Agard, E., Chaperon, M., Billant, J., Denis, P., Mathis, T., Burillon, C., & Dot, C. (2023). Focal Photocoagulation as an Adjunctive Therapy to Reduce the Burden of Intravitreal Injections in Macula Edema Patients, the LyoMAC2 Study. Pharmaceutics, 15(2), 308. https://doi.org/10.3390/pharmaceutics15020308

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