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Pharmaceutics
Volume 15
Issue 3
10.3390/pharmaceutics15030731
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Article

High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy

by
De Bai
1,†,
Fan Hu
2,3,†,
Huixian Xu
4,
Jiahong Huang
1,
Chengyu Wu
1,4,*,
Jiaheng Zhang
1,4 and
Rui Ye
2,3,*
1
Sauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China
2
Inertia Shanghai Biotechnology Co., Ltd., Shanghai 200000, China
3
DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai 200000, China
4
Shenzhen Shinesky Biological Technology Co., Ltd., Shenzhen 518055, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2023, 15(3), 731; https://doi.org/10.3390/pharmaceutics15030731
Submission received: 30 December 2022 / Revised: 13 February 2023 / Accepted: 16 February 2023 / Published: 22 February 2023
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Abstract

Gravi-A nanoparticles, composed of retinyl propionate (RP) and hydroxypinacolone retinoate (HPR), were prepared by encapsulating the two using the high-pressure homogenization technique. The nanoparticles are effective in anti-wrinkle treatment with high stability and low irritation. We evaluated the effect of different process parameters on nanoparticle preparation. Supramolecular technology effectively produced nanoparticles with spherical shapes with an average size of 101.1 nm. The encapsulation efficiency was in the 97.98–98.35% range. The system showed a sustained release profile for reducing the irritation caused by Gravi-A nanoparticles. Furthermore, applying lipid nanoparticle encapsulation technology improved the transdermal efficiency of the nanoparticles, thereby allowing these to penetrate deep into the dermis layer to achieve precise and sustained release of active ingredients. Gravi-A nanoparticles can be extensively and conveniently used in cosmetics and other related formulations by direct application.
Keywords: retinyl propionate; hydroxypinacolone retinoate; gravi-A nanoparticles; high stability; low irritation; transdermal delivery efficiency retinyl propionate; hydroxypinacolone retinoate; gravi-A nanoparticles; high stability; low irritation; transdermal delivery efficiency

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MDPI and ACS Style

Bai, D.; Hu, F.; Xu, H.; Huang, J.; Wu, C.; Zhang, J.; Ye, R. High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy. Pharmaceutics 2023, 15, 731. https://doi.org/10.3390/pharmaceutics15030731

AMA Style

Bai D, Hu F, Xu H, Huang J, Wu C, Zhang J, Ye R. High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy. Pharmaceutics. 2023; 15(3):731. https://doi.org/10.3390/pharmaceutics15030731

Chicago/Turabian Style

Bai, De, Fan Hu, Huixian Xu, Jiahong Huang, Chengyu Wu, Jiaheng Zhang, and Rui Ye. 2023. "High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy" Pharmaceutics 15, no. 3: 731. https://doi.org/10.3390/pharmaceutics15030731

APA Style

Bai, D., Hu, F., Xu, H., Huang, J., Wu, C., Zhang, J., & Ye, R. (2023). High Stability and Low Irritation of Retinol Propionate and Hydroxypinacolone Retinoate Supramolecular Nanoparticles with Effective Anti-Wrinkle Efficacy. Pharmaceutics, 15(3), 731. https://doi.org/10.3390/pharmaceutics15030731

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