A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy
Uwe Wolina
Round 1
Reviewer 1 Report
Thank you for submitting your manuscript on improvement of topical treatment of psoriasis.
- The title should be changed. "to treating psoriasis" - to treat
- p.1, l. 18: "treat skin conditions such as dermatoses, skin allergies, and psoriasis". Psoriasis and skin allergies are dermatoses.
- p.1, l. 39 - the same.
- Methods: Please mention the number of mice treated in the various groups.
- p.7, l.263: "DXM showed the more effective therapeutical effect than Esperson and Clobetasol" - DMX was more effective than....
- p.9, l.289: "3.4. DXM, ESP, and CLO Inhibit IL-23/IL-17/TNF-α axis protein..."
- inhibit.
- p.10, l.319: "improve dermatitis and may help reduce the recurrence of psoriasis" - psoriasis has been investigated. Please avoid the nonspecific term dermatitis. An effect on psoriasis recurrence has not been demonstrated by your experiment.
- p.14, l. 431: "It has been reported that the therapeutic potential of desoximetasone is in treating skin inflammation and autoimmune disorders" -
Desoximetahsone has a therapeutic potential in the treatment of ...
General aspects: Please explain why desoximethasone was used instead of any other corticosteroid?
The paper needs significant improvement in English.
Author Response
Reviewer 1
Thank you for submitting your manuscript on improvement of topical treatment of psoriasis.
Response: We thank the reviewer for the valuable suggestions and recommendations regarding this research.
- The title should be changed. "to treating psoriasis" - to treat
Response: We have revised the paper title as “A promising approach to treat psoriasis: inhibiting cyto-chrome P450 3A4 metabolism to enhance desoximetasone therapy”.
- p.1, l. 18: "treat skin conditions such as dermatoses, skin allergies, and psoriasis". Psoriasis and skin allergies are dermatoses.
- p.1, l. 39 - the same.
Response: We have revised both the sentences as “Desoximetasone, a topical corticosteroid and cytochromes P450 3A4 substrate, is used to treat skin conditions such as skin allergies, atopic dermatitis, and psoriasis. (page 1, Line 18-19, and 39-40).
- Methods: Please mention the number of mice treated in the various groups.
Response: We have revised and provided the number of mice treated in the various groups.
- p.7, l.263: "DXM showed the more effective therapeutical effect than Esperson and Clobetasol" - DMX was more effective than....
Response: We have revised the sentences as “DMX was more effective than Esperson and Clobetasol (page 7, Line 280-281).
- p.9, l.289: "3.4. DXM, ESP, and CLO Inhibit IL-23/IL-17/TNF-α axis protein..."
- inhibit.
Response: We have revised the sentences as “DXM, ESP, and CLO inhibit IL-23/IL-17/TNF-α axis protein in psoriasis-like skin” (page 9, Line 308-309).
- p.10, l.319: "improve dermatitis and may help reduce the recurrence of psoriasis" - psoriasis has been investigated. Please avoid the nonspecific term dermatitis. An effect on psoriasis recurrence has not been demonstrated by your experiment.
Response: We have revised the sentences as “These findings suggest that the DXM-loaded formulation can effectively improve the therapeutic effect in psoriasis.” (page 10, Line 340-341).
- p.14, l. 431: "It has been reported that the therapeutic potential of desoximetasone is in treating skin inflammation and autoimmune disorders" -
Desoximetahsone has a therapeutic potential in the treatment of ...
Response: We have revised both the sentences as “Desoximetahsone has a therapeutic potential in the treatment of skin inflammation and autoimmune disorders.” (page 14, Line 458-459).
General aspects: Please explain why desoximethasone was used instead of any other corticosteroid?
Response: Desoximetasone (C22H29FO4; , MW ＝ 376.5), which is a substrate of CYP3A4, is a potent topical corticosteroid used to alleviate various skin conditions, such as skin allergies, atopic dermatitis, and psoriasis. Desoximetasone is also safe with topical bioavailability steroids; it is used as a routine topical steroid at several medical centers in Taiwan, including Cathay General Hospital.
Comments on the Quality of English Language
The paper needs significant improvement in English.
Response: This article has been professionally edited by the MDPI English Editing Center's Specialist service.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This is a very good manuscript on an important topic. Very well-designed study, with very well-presented results. The study is clearly justified and executed without any flaws. I recommend to accept the study as it is.
Author Response
Reviewer 2
This is a very good manuscript on an important topic. Very well-designed study, with very well-presented results. The study is clearly justified and executed without any flaws. I recommend to accept the study as it is.
Response: We sincerely appreciate the approval and recommendation from the reviewer for the recognition of our research findings.
Author Response File: Author Response.pdf
