Multifunctional Bioactivity Electrospinning Nanofibers Encapsulating Emodin Provides a Potential Postoperative Management Strategy for Skin Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Coaxial Electrospinning Nanofibers
2.3. Characterization of Electrospinning Nanofibers
2.3.1. Morphologies
2.3.2. Attenuated Total Reflection–Fourier Transform Infrared Spectra Analysis
2.3.3. X-ray Diffraction
2.3.4. Differential Scanning Calorimetry
2.3.5. Wettability and Swelling Ratio
2.3.6. Encapsulation Efficiency and Drug Release Profiles
2.4. Cytocompatibility
2.5. Anti-Cancer Effects
2.6. Mechanism of Anti-Cancer Effects
2.6.1. Cell Death Inhibitors
2.6.2. MDA Level
2.6.3. ROS Level
2.7. Anti-Bacterial Activities
2.8. Statistical Analysis
3. Results and Discussion
3.1. Optimized Electrospinning Conditions
3.2. Characterization
3.2.1. Morphology
3.2.2. ATR-FTIR Spectra Analysis
3.2.3. X-ray Diffraction
3.2.4. Differential Scanning Calorimetry
3.2.5. Swelling Ratio and Contact Angle
3.2.6. Encapsulation Efficiency and Release Profiles
3.3. Cytocompatibility with Normal Cells
3.4. Anti-Cancer Effects
3.5. Anti-Cancer Effect Mechanism
3.5.1. Inhibit Cancer Cell Proliferation via Necroptosis and Apoptosis Pathway
3.5.2. MDA Level in Tumor Cells
3.5.3. ROS Level in Tumor Cells
3.6. Anti-Bacterial Activities
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ye, P.; Yusufu, R.; Guan, Z.; Chen, T.; Li, S.; Feng, Y.; Zeng, X.; Lu, J.; Luo, M.; Wei, F. Multifunctional Bioactivity Electrospinning Nanofibers Encapsulating Emodin Provides a Potential Postoperative Management Strategy for Skin Cancer. Pharmaceutics 2024, 16, 1131. https://doi.org/10.3390/pharmaceutics16091131
Ye P, Yusufu R, Guan Z, Chen T, Li S, Feng Y, Zeng X, Lu J, Luo M, Wei F. Multifunctional Bioactivity Electrospinning Nanofibers Encapsulating Emodin Provides a Potential Postoperative Management Strategy for Skin Cancer. Pharmaceutics. 2024; 16(9):1131. https://doi.org/10.3390/pharmaceutics16091131
Chicago/Turabian StyleYe, Peiwen, Reyisha Yusufu, Zhenfeng Guan, Tiantian Chen, Siyi Li, Yanping Feng, Xiaoyan Zeng, Jingya Lu, Muxiang Luo, and Fenghuan Wei. 2024. "Multifunctional Bioactivity Electrospinning Nanofibers Encapsulating Emodin Provides a Potential Postoperative Management Strategy for Skin Cancer" Pharmaceutics 16, no. 9: 1131. https://doi.org/10.3390/pharmaceutics16091131