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Infectious Disease Reports, Volume 17, Issue 5

2025 October - 32 articles

Cover Story: Pulmonary hypertension (PH) disproportionately affects those residing in low- and middle-income countries (LMICs). These countries also have a high prevalence of infectious diseases, and many cases of PH are either directly or indirectly related to infectious etiologies. Despite this correlation, the precise burden of infectious disease-associated PH is largely underappreciated due to a lack of diagnostic resources, a shortage of clinical expertise to carry out right heart catheterization, and poor access to healthcare facilities in many low- and middle-income settings. This narrative review highlights the significant burden of infectious disease-associated PH in LMICs, outlines the technical challenges faced by LMICs when diagnosing PH, and proposes possible solutions for diagnosing PH in resource-constrained settings. View this paper
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Articles (32)

  • Article
  • Open Access
568 Views
13 Pages

Knowledge, Attitude and Practices of Primary Care Physicians Regarding Infection Control of Tuberculosis in Primary Health Care Centers, Riyadh, Saudi Arabia

  • Yasser Alhazzani,
  • Abdulaziz Nasser Alahmari,
  • Bandar K. AlRabiah,
  • Khalid F. Alsadhan,
  • Abdulaziz Yahya Sahhari and
  • Fahad Alrabieah

20 October 2025

Background: Tuberculosis (TB) remains a public health concern in Saudi Arabia, where primary care physicians play a crucial role in early detection and infection control. This study assessed physicians’ knowledge, attitudes, and practices (KAP)...

  • Brief Report
  • Open Access
1,412 Views
12 Pages

Common Superficial Bacterial Skin Infections Self-Reported by 1047 Greek Competitive Swimmers: A 2021 Retrospective Study

  • Eleni Sfyri,
  • Niki Tertipi,
  • Vasiliki Kefala,
  • Vasiliki-Sofia Grech and
  • Efstathios Rallis

20 October 2025

Background/Objectives: Superficial bacterial skin infections are common, particularly among athletes. In swimming, data on folliculitis, impetigo, and pitted keratolysis are limited. This study aimed to evaluate the prevalence of superficial bacteria...

  • Article
  • Open Access
623 Views
10 Pages

Distribution and Factors Associated with Neisseria gonorrhoeae Cases in Kampala, Uganda, 2016–2020

  • Fahad Lwigale,
  • Conrad Tumwine,
  • Reuben Kiggundu,
  • Patrick Elungat,
  • Hope Mackline,
  • Dathan M. Byonanebye,
  • Andrew Kambugu and
  • Francis Kakooza

17 October 2025

Background: Gonorrhoea is a common sexually transmitted infection with serious health consequences if not well-treated. Resistance to common therapeutic agents and limited diagnostics further heighten its burden on sexual and reproductive health. Thi...

  • Article
  • Open Access
614 Views
12 Pages

Development of a PCR Assay for the Detection of Legionella micdadei in the Environment

  • William N. Bélanger,
  • Martine Bastien,
  • Eve Bérubé,
  • Martin Gagnon,
  • Yesmine G. Sahnoun,
  • Valérie Dancause,
  • Karel Boissinot,
  • Cindy Lalancette,
  • Christian Riel-Roberge and
  • Sandra Isabel
  • + 6 authors

17 October 2025

Background/Objectives: Legionella micdadei is a clinically significant species within the Legionella genus, requiring accurate detection methods, surveillance, and precise clinical diagnosis. Our objective was to develop a sensitive polymerase chain...

  • Case Report
  • Open Access
503 Views
8 Pages

Quantification of Bacterial and Drug-Resistant DNA Using dPCR in a Pediatric Patient with CVC-Related Bloodstream Infection

  • Masato Kojima,
  • Hiroki Kitagawa,
  • Kayoko Tadera,
  • Ryo Touge,
  • Sho Kurihara,
  • Mari Tanaka,
  • Maiko Shimomura,
  • Isamu Saeki and
  • Hiroki Ohge

16 October 2025

Background: Digital polymerase chain reaction (dPCR) is a highly sensitive molecular method that allows rapid detection of bacterial DNA and resistance genes, requiring only a small blood volume. Although not a new technology, its application in pedi...

  • Article
  • Open Access
640 Views
36 Pages

Assessment of Cryptosporidium spp. Sub-Families and Giardia duodenalis Assemblages A and B in Ghanaian HIV Patients, Including Socio-Economic, Clinical, and Immunological Associations

  • Lynn Glyschewski,
  • Hagen Frickmann,
  • Fred Stephen Sarfo,
  • Betty Roberta Norman,
  • Albert Dompreh,
  • Emmanuel Acheamfour-Akowuah,
  • Martin Kofi Agyei,
  • Shadrack Osei Asibey,
  • Richard Boateng and
  • Kirsten Alexandra Eberhardt
  • + 7 authors

15 October 2025

Background: Cryptosporidium spp. cause opportunistic infections in immunosuppressed individuals, such as people living with HIV (PLWH). However, the association between giardiasis and HIV infection remains uncertain. This study assessed co-infections...

  • Article
  • Open Access
806 Views
12 Pages

HIV-1 Subtype Diversity in Morocco: Signals of Change and Implications for National Surveillance

  • Maryam Ahmina,
  • Hicham El Annaz,
  • Nada Lamrak,
  • Ahmed Reggad,
  • Mohamed Rida Tagajdid,
  • Rachid Abi,
  • Mohamed Elqatni,
  • Abdelilah Laraqui,
  • Safae Elkochri and
  • Idriss Lahlou Amine
  • + 5 authors

14 October 2025

Background: Limited molecular surveillance continues to constrain Morocco’s HIV response, leaving subtype dynamics largely underreported. Once characterized by a predominance of subtype B, the Moroccan epidemic now appears to reflect shifting p...

  • Article
  • Open Access
602 Views
7 Pages

The Neutrophil/Lymphocyte Ratio Was Identified as a Marker of Severe Influenza During the 2024–2025 Outbreak in France

  • Matteo Vassallo,
  • Marion Derollez,
  • Marc-Hadrien Veaute,
  • Nicolas Clement,
  • Roxane Fabre,
  • Laurene Lotte,
  • Yanis Kouchit,
  • Sabrina Manni,
  • Ursula Moracchini and
  • Pierre-Marie Bertrand
  • + 8 authors

10 October 2025

Background/Objectives: Influenza continues to cause high morbidity and mortality rates worldwide, inflicting a major burden on the public health system. There is little data available on the 2024–2025 seasonal outbreak. Moreover, biomarkers for...

  • Article
  • Open Access
1 Citations
729 Views
16 Pages

Background: Cervical cancer remains a significant global public health concern, with human papillomavirus (HPV) vaccination serving as an effective preventive measure. Despite its proven efficacy, HPV vaccine uptake in Jordan remains low. This study...

  • Case Report
  • Open Access
743 Views
7 Pages

Cutaneous Leishmaniasis in the Immunocompromised: Diagnostic and Therapeutic Insights from a Case Documented in Central Italy

  • Laura Povolo,
  • Anna Barbiero,
  • Michele Spinicci,
  • Nicola Petrosillo,
  • Alessandro Bartoloni and
  • Lorenzo Zammarchi

Introduction: Cutaneous leishmaniasis (CL) poses a number of challenges when it comes to diagnosis and treatment, due to the variety of clinical presentations that mimic other conditions and hinder the choice of the most appropriate therapeutic appro...

  • Review
  • Open Access
1 Citations
910 Views
13 Pages

Public Health Impact of the MVA-BN Vaccine During the 2022 Mpox Outbreak: A Systematic Review

  • Sarah C. Katsandres,
  • Suzanne K. Scheele,
  • Takako Kiener and
  • Lisa Bloudek

Background/Objectives: Previously endemic to sub-Saharan Africa, mpox has since emerged globally, resulting in more than 150,000 cases in over 100 countries in the 2022 outbreak. The Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine is licens...

  • Article
  • Open Access
741 Views
14 Pages

Dolutegravir Resistance in Mozambique: Insights from a Programmatic HIV Resistance Testing Intervention in a Highly Antiretroviral Therapy-Experienced Cohort

  • Maria Ruano,
  • Antonio Flores,
  • Aleny Couto,
  • Irénio Gaspar,
  • Sabine Yerly,
  • Ana Gabriela Gutierrez Zamudio,
  • Rosa Bene,
  • Adelina Maiela,
  • Helder Macuacua and
  • Edy Nacarapa
  • + 2 authors

30 September 2025

Background: Treatment failure continues to play a role in HIV-related morbidity in Mozambique. Antiretroviral therapy (ART) regimen switches are decided empirically, as HIV genotypic resistance testing (HIV-GT) is unavailable in Mozambique’s pu...

  • Article
  • Open Access
509 Views
18 Pages

Profile, Infection, and Vaccination Uptake: A Cohort of Canadian Retail Workers During the SARS-CoV-2 Pandemic

  • Mathieu Thériault,
  • Kim Santerre,
  • Nicholas Brousseau,
  • Samuel Rochette,
  • Rabeea F. Omar,
  • Joelle N. Pelletier,
  • Caroline Gilbert,
  • Jean-François Masson,
  • Mariana Baz and
  • Sylvie Trottier
  • + 1 author

29 September 2025

Background/Objectives: Retail workers may have been at an increased risk of contracting SARS-CoV-2 during the COVID-19 pandemic. To better understand this group, we set up a longitudinal cohort to document the occurrence of SARS-CoV-2 infection, vacc...

  • Case Report
  • Open Access
1 Citations
1,123 Views
14 Pages

24 September 2025

Background: Reactive Infectious Mucocutaneous Eruption (RIME) is a mucositis-predominant syndrome that usually follows respiratory infections in children. Although Mycoplasma pneumoniae is a well-established trigger, viral pathogens as triggers&mdash...

  • Review
  • Open Access
1,605 Views
16 Pages

Clean to Prevent, Monitor to Protect: A Scoping Review on Strategies for Monitoring Cleaning in Hospitals to Prevent HAIs

  • Biagio Santella,
  • Antonio Donato,
  • Luigi Fortino,
  • Vittoria Satriani,
  • Rosaria Flora Ferrara,
  • Emanuela Santoro,
  • Walter Longanella,
  • Gianluigi Franci,
  • Mario Capunzo and
  • Giovanni Boccia

21 September 2025

Background/Objectives: Hospital environmental contamination represents a significant source of healthcare-associated infections, yet standardized monitoring approaches are still inconsistent globally. This scoping review aimed to find and assess vari...

  • Article
  • Open Access
861 Views
16 Pages

Characterization of Carbapenem-Resistant Gram-Negative Bacilli Isolates in Multispecialty Private Hospitals in Lagos, Nigeria

  • Moruf Salau,
  • Uraiwan Kositanont,
  • Pirom Noisumdaeng,
  • Folasade Ogunsola,
  • Abdul-Wahab Omo-ope Ettu,
  • Damilola Adewojo,
  • Chinonso Ojimma,
  • Omamode Ojomaikre and
  • Kanjana Changkaew

21 September 2025

Background/Objectives: Carbapenem-resistant Gram-negative bacilli (CR-GNB) pose a growing challenge to public health worldwide due to limited treatment options. This cross-sectional study investigated the characteristics of CR-GNB isolated from clini...

  • Review
  • Open Access
1 Citations
2,117 Views
24 Pages

State of the Art on Vaccine Development Against Dengue Infection: Scoping Review of the Literature

  • Davide Marangoni,
  • Anna Barbiero,
  • Michele Spinicci,
  • Alessandro Bartoloni,
  • Andrea Rossanese,
  • Paolo Bonanni and
  • Lorenzo Zammarchi

17 September 2025

Background: Dengue virus infection is a significant challenge for global health, with 100 million symptomatic cases, 2.3 million DALYs and 20,000 deaths annually. Dengue vaccines must provide long-lasting immunity against all four virus serotypes, es...

  • Brief Report
  • Open Access
654 Views
8 Pages

Pathways to Diagnose Infectious Pulmonary Vascular Disease in Rural Mozambique

  • Yolanda Sabino,
  • Cizália Ribeiro,
  • Joshua Mungue and
  • Ana Olga Mocumbi

15 September 2025

Background: Schistosomiasis, HIV, and tuberculosis frequently lead to pulmonary hypertension in low- and middle-income countries. Lack of specific testing and limited access to right heart catheterization hamper confirmation of the etiology of pulmon...

  • Article
  • Open Access
3 Citations
1,391 Views
13 Pages

Uneven Implementation of Nirsevimab Prophylaxis Resulted in Non-Uniform Reductions in RSV-Related Hospitalizations in Italy

  • Melodie O. Aricò,
  • Francesco Accomando,
  • Daniela Trotta,
  • Giulia Marozzi,
  • Anthea Mariani,
  • Claudia Rossini,
  • Claudio Cafagno,
  • Letizia Lorusso,
  • Martina Fornaro and
  • Maurizio Aricò
  • + 2 authors

12 September 2025

Background/Objectives: Respiratory syncytial virus (RSV) bronchiolitis remains a leading cause of hospitalization in infants. In the 2024–2025 season, passive newborn immunization with nirsevimab, a long-acting anti-RSV monoclonal antibody, was...

  • Article
  • Open Access
758 Views
13 Pages

Uncommon Pathogens in Common Presentations: Genetic Profiling and Virulence Determinants of Vibrio alginolyticus Isolated from a Case of External Otitis

  • Radu Ovidiu Togănel,
  • Razvan Lucian Coșeriu,
  • Anca Delia Mare,
  • Camelia Vintilă,
  • Ioan-Ovidiu Sîrbu,
  • Aimée Rodica Chis,
  • Cristina Elena Gîrbovan and
  • Adrian Man

12 September 2025

Backgrunod/Objectives: Routine identification of common bacterial pathogens is typically efficient, utilizing standardized, cost-effective methods. However, the diagnostic process becomes significantly more complex when dealing with rare or unexpecte...

  • Article
  • Open Access
1,073 Views
11 Pages

Imported Dengue Fever in Milan, Italy: A Seven-Year Retrospective Study

  • Margherita Eleonora Pieruzzi,
  • Davide Mileto,
  • Alessandra Helen Behring,
  • Stefania Caronni,
  • Alessandro Mancon,
  • Luigi Vezzosi,
  • Alberto Rizzo,
  • Andrea Poloni,
  • Andrea Gori and
  • Spinello Antinori
  • + 1 author

12 September 2025

Background: Dengue fever is an arboviral infection transmitted by Aedes mosquitoes that has recently become a public health concern also in Europe, causing many outbreaks of autochthonous cases. Methods: We retrospectively retrieved dengue cases in r...

  • Article
  • Open Access
1,175 Views
10 Pages

11 September 2025

Background: This study aimed to describe cefiderocol prescription and associated patient outcomes at a U.S. academic medical center for various multidrug-resistant organisms (MDRO). Notably, limited real-world data exist on cefiderocol’s clinic...

  • Article
  • Open Access
670 Views
14 Pages

Circulation of SARS-CoV-2 and Co-Infection with Plasmodium falciparum in Equatorial Guinea

  • Diana López-Farfán,
  • Policarpo Ncogo,
  • Consuelo Oki,
  • Matilde Riloha,
  • Valero Ondo,
  • Pablo Cano-Jiménez,
  • Francisco José Martínez-Martínez,
  • Irene Molina-de la Fuente,
  • Iñaki Comas and
  • Elena Gómez-Díaz
  • + 3 authors

10 September 2025

Background/Objectives: The impact of COVID-19 in Africa has been controversial. Data from African countries are heterogeneous and generally scarce. Many regions are also highly endemic for other infectious diseases like malaria, and it has been sugge...

  • Article
  • Open Access
720 Views
18 Pages

One Month Preexposure Prophylaxis Retention Rate and Associated Factors Among Adolescent Girls and Young Women Who Participated in the Namibia DREAMS Program (2018–2024)

  • Enos Moyo,
  • Endalkachew Melese,
  • Hadrian Mangwana,
  • Simon Takawira,
  • Rosalia Indongo,
  • Bernadette Harases,
  • Perseverance Moyo,
  • Ntombizodwa Makurira Nyoni,
  • Kopano Robert and
  • Tafadzwa Dzinamarira

10 September 2025

Background: Daily oral preexposure prophylaxis (PrEP) is one strategy employed to decrease HIV transmission among adolescent girls and young women (AGYW). The Determined, Resilient, Empowered, AIDS-Free, Mentored, and Safe (DREAMS) program, funded by...

  • Review
  • Open Access
1 Citations
875 Views
15 Pages

Technical Challenges in Studying Infectious Disease-Associated Pulmonary Hypertension in Low- and Middle-Income Countries with Limited Resources

  • Jennifer van Heerden,
  • Irina Mbanze,
  • Elizabeth Louw,
  • Olukayode Aremu,
  • Anastase Dzudie,
  • Ana Mocumbi,
  • Threnesan Naidoo,
  • Brian Allwood and
  • Friedrich Thienemann

10 September 2025

Background: Pulmonary hypertension (PH) disproportionately affects those residing in low- and middle-income countries (LMICs). Given that these countries also have a high prevalence of infectious diseases, many cases of PH are either directly or indi...

  • Article
  • Open Access
1 Citations
3,083 Views
9 Pages

Sex, Age, and COVID-19 Vaccine Characteristics Associated with Adverse Events After Vaccination and Severity: A Retrospective Analysis

  • Edgar P. Rodríguez-Vidales,
  • Jesús M. Santos-Flores,
  • Mara I. Garza-Rodríguez,
  • Ana M. Salinas-Martínez,
  • Alejandra G. Martínez-Pérez,
  • Roberto Montes de Oca-Luna and
  • Alma R. Marroquín-Escamilla

3 September 2025

Background: Although the safety of COVID-19 vaccines has been demonstrated in clinical trials, real-world pharmacovigilance remains essential to detect rare or unexpected adverse events following immunization (AEFI). In Mexico, the national AEFI surv...

  • Article
  • Open Access
1 Citations
873 Views
19 Pages

2 September 2025

Background: Torque Teno Virus (TTV) viremia has been proposed as a marker for infection risk in kidney transplant (KT) recipients. This study aimed to evaluate the prognostic value of TTV levels for predicting infections post-KT. Methods: A cohort of...

  • Case Report
  • Open Access
1,156 Views
8 Pages

Hyponatremia Due to VZV-Induced SIADH in an Older Patient: Case Report and Literature Review

  • Zuzanna Żak-Skryśkiewicz,
  • Patrycja Krupińska,
  • Carlo Bieńkowski and
  • Przemysław Witek

Introduction: Hyponatremia is a common finding in hospitalized patients, especially the elderly. Symptoms of hyponatremia can vary depending on the concentration of sodium in serum as well as the dynamics of its escalation. Hyponatremia can have many...

  • Article
  • Open Access
1,399 Views
17 Pages

Introduction: Central line-associated bloodstream infections (CLABSIs) are a major cause of morbidity and mortality, yet health disparities in CLABSI incidence and outcomes remain understudied. This study evaluates these disparities and their impact...

  • Article
  • Open Access
2 Citations
1,164 Views
20 Pages

Oral Immunization with Yeast-Surface Display of SARS-CoV-2 Antigens in Pichia pastoris Induces Humoral Responses in BALB/C Mice

  • Larissa Silva de Macêdo,
  • Benigno Cristofer Flores Espinoza,
  • Maria da Conceição Viana Invenção,
  • Samara Sousa de Pinho,
  • Lígia Rosa Sales Leal,
  • Micaela Evellin dos Santos Silva,
  • Beatriz Mendonça Alves Bandeira,
  • Pedro Vinícius Silva Novis,
  • Tiago Henrique dos Santos Souza and
  • Anna Jéssica Duarte Silva
  • + 3 authors

Background/Objectives: The pandemic caused by SARS-CoV-2 boosted the development of different vaccine models. In parallel, yeasts stand out as a vaccine platform in healthcare biotechnology. Species such as Saccharomyces cerevisiae and Pichia pastori...

  • Case Report
  • Open Access
822 Views
7 Pages

Concomitant Neck and Lung Masses Post Dental Procedure—A Potential Novel Presentation of the Cellulosimicrobium Species in Humans

  • Kevin M. Sheehan,
  • Geraldine Moloney,
  • Olive Murphy,
  • Paul Ryan,
  • Triona Hayes,
  • Madeleine R. Harney,
  • Michael Harney and
  • Oisin O’Connell

Background: Cellulosimicrobium, formerly known as the Oerskovia genus, is a Gram-positive organism known for its characteristic bright yellow colonies. While abundant in nature, it is very rarely linked to pathogenesis in humans. While there is no cl...

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Infect. Dis. Rep. - ISSN 2036-7449