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Pediatric Reports, Volume 17, Issue 3

2025 June - 19 articles

Cover Story: Pediatric multiple sclerosis (MS) is a rare and complex neuroinflammatory disease characterized by demyelination and neurological dysfunction in individuals under 18 years of age. This systematic review and Activation Likelihood Estimation meta-analysis synthesize the existing literature on functional and structural brain alterations in patients. The results reveal alterations in key regions for cognitive and motor functions, such as the thalamus, cerebellum, and hippocampus. The meta-analysis identifies significant involvement of the dorsal anterior cingulate cortex, angular gyrus, and superior parietal lobes, regions associated with cognition, attention, and working memory. These findings suggest that pediatric MS uniquely affects brain development, contributing to cognitive impairments different from those observed in adult MS. View this paper
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Articles (19)

  • Article
  • Open Access
1 Citations
2,373 Views
16 Pages

Pubertal Timing and Health-Related Quality of Life—A Cross-Sectional Study of Polish Adolescents

  • Zbigniew Izdebski,
  • Alicja Kozakiewicz,
  • Katarzyna Porwit,
  • Michalina Aleksandra Gryglewska and
  • Joanna Mazur

Background/Objectives: In research on the relationship between pubertal timing and adolescent health, more attention is typically given to early rather than late maturation, as well as the associated risk of engaging in health-compromising behaviors....

  • Article
  • Open Access
1,129 Views
14 Pages

Background/Objectives: Increased burdens on caregivers of infants and toddlers significantly affect caregivers’ quality of life and health. Although adequate care during infancy contributes to child development and special health care needs aff...

  • Systematic Review
  • Open Access
2,119 Views
28 Pages

Impact of Maternal Microbiota Composition on Neonatal Immunity and Early Childhood Allergies: A Systematic Review

  • Ayah Nabil Al Jehani,
  • Manal Shuaib,
  • Arwa Alsharif,
  • Khlood Abdulaziz Alsubaie,
  • Ayda Khraisat,
  • Abdulaziz Alsharif,
  • Manaf Altaf,
  • Ruba H. Almasry,
  • Amal Mohamed Kayali and
  • Shouq Abdin Abdallah

Background: The maternal microbiota serve as a key regulator of neonatal immune development and early-life health outcomes. This systematic review aims to find out how the makeup of the maternal microbiota affects newborn immunity and the risk of all...

  • Review
  • Open Access
3 Citations
5,742 Views
39 Pages

Exploring the Impact of Emotional Eating in Children: A Narrative Review

  • Maria Mentzelou,
  • Sousana K. Papadopoulou,
  • Evmorfia Psara,
  • Olga Alexatou,
  • Theodosis Koimtsidis and
  • Constantinos Giaginis

Background/Objectives: Emotional eating has been recognized as the tendency to eat in response to emotions, being recognized as a crucial risk factor for recurrent weight gain. Emotional eating has been interrelated with obesity/overweight, depressio...

  • Review
  • Open Access
5 Citations
4,215 Views
23 Pages

Neuroimaging and Emotional Development in the Pediatric Population: Understanding the Link Between the Brain, Emotions, and Behavior

  • Giuseppe Marano,
  • Maria Benedetta Anesini,
  • Miriam Milintenda,
  • Mariateresa Acanfora,
  • Claudia Calderoni,
  • Francesca Bardi,
  • Francesco Maria Lisci,
  • Caterina Brisi,
  • Gianandrea Traversi and
  • Marianna Mazza
  • + 4 authors

Neuroimaging has emerged as an innovative and essential tool for understanding the intricate relationship between brain development, emotions, and behavior. Investigating the neurobiological mechanisms underlying this interaction during the critical...

  • Article
  • Open Access
979 Views
14 Pages

Assessing the Implementation and Awareness of Children’s Rights in Pediatric Hospital: A Comparative Study of Parents’ and Children’s Perspectives

  • Vasiliki Georgousopoulou,
  • Chrysoula Dafogianni,
  • Pinelopi Vlotinou,
  • Aspasia Serdari,
  • Ioannis Koutelekos,
  • Anna Tsiakiri,
  • Dimitrios Cassimos,
  • Maria Lavdaniti,
  • Maria Amanatidou and
  • Georgios Manomenidis

To evaluate and compare the awareness and implementation of children’s rights in pediatric hospital settings from the perspectives of parents and children, this study emphasizes ethical considerations in healthcare, focusing on communication pr...

  • Review
  • Open Access
2 Citations
5,426 Views
39 Pages

Targeting the Roots of Psychosis: The Role of Aberrant Salience

  • Giuseppe Marano,
  • Francesco Maria Lisci,
  • Greta Sfratta,
  • Ester Maria Marzo,
  • Francesca Abate,
  • Gianluca Boggio,
  • Gianandrea Traversi,
  • Osvaldo Mazza,
  • Roberto Pola and
  • Marianna Mazza
  • + 1 author

Aberrant salience, defined as the inappropriate attribution of significance to neutral stimuli, is increasingly recognized as a critical mechanism in the onset of psychotic disorders. In young individuals at ultra-high risk (UHR) for psychosis, abnor...

  • Editorial
  • Open Access
629 Views
4 Pages

Over the past decade, the field of childhood histiocytosis, particularly Langerhans cell histiocytosis (LCH), has undergone transformative changes. The integration of molecular genetics, targeted therapies, and refined diagnostic methodologies has re...

  • Article
  • Open Access
1,346 Views
19 Pages

Psychopathological Comorbidities in Children and Adolescents with Feeding and Eating Disorders: An Italian Clinical Study

  • Maria Califano,
  • Jacopo Pruccoli,
  • Oliviero Cavallino,
  • Alessandra Lenzi and
  • Antonia Parmeggiani

Objectives: Feeding and eating disorders (FED) represent a major public health issue and are the second leading cause of death among psychiatric conditions in children and adolescents. Psychopathological comorbidities play a significant role in the o...

  • Viewpoint
  • Open Access
5,397 Views
9 Pages

When Care Becomes Abuse: A Forensic–Medical Perspective on Munchausen Syndrome by Proxy

  • Emanuele Capasso,
  • Carola Costanza,
  • Michele Roccella,
  • Beatrice Gallai,
  • Michele Sorrentino and
  • Marco Carotenuto

Munchausen Syndrome by Proxy (MSBP) is recognized as a form of child abuse in which a caregiver induces or fabricates illnesses in their child to gain medical and social attention. MSBP represents one of the most complex and insidious forms of child...

  • Systematic Review
  • Open Access
1 Citations
8,610 Views
15 Pages

Mindfulness-Based Interventions (MBIs) are important tools to address mental health issues in children and adolescents. However, previous studies provided variable results that suggest that the effectiveness of those third-wave Cognitive Behavioral T...

  • Article
  • Open Access
1 Citations
1,357 Views
14 Pages

Background/Objectives: Pediatric postoperative respiratory failure in the United States is increasingly considered a significant adverse event due to the increased risk of co-morbidities, suffering, and cost of healthcare. This study investigates ass...

  • Systematic Review
  • Open Access
1 Citations
1,470 Views
32 Pages

Background/Objectives: Pediatric multiple sclerosis (MS) is a rare and complex neuroinflammatory disease characterized by demyelination and neurological dysfunction in individuals under 18 years of age. This systematic review and activation likelihoo...

  • Article
  • Open Access
681 Views
10 Pages

Exploring Partners, Parenting and Pregnancy Thinking in Late Adolescents and Young Adults with Inherited Metabolic Disorders

  • Albina Tummolo,
  • Giulia Paterno,
  • Rosa Carella,
  • Livio Melpignano and
  • Donatella De Giovanni

Introduction: The psychosocial impact of living with an Inherited Metabolic Disorder (IMD) is becoming increasingly relevant and can have a significant impact on planning the future, conditioning the reproductive decisions made during adolescence and...

  • Article
  • Open Access
2,884 Views
18 Pages

Affective Neuroscience Personality Scale (ANPS) in Children with Internalizing Disorders

  • Simone Cupellaro,
  • Valentina Colonnello,
  • Ugo Sabatello,
  • Chiara Ubertini and
  • Carla Sogos

Background/Objectives: This study of endophenotypes represents a new research approach to overcome the limits of a syndromic model to psychiatric diseases. The Affective Neuroscience Personality Scales (ANPS, 31) is a self-report questionnaire used t...

  • Case Report
  • Open Access
2 Citations
1,215 Views
9 Pages

A De Novo PTEN Pathogenic Variant in a Young Girl with Sporadic Cowden Syndrome—A Case Report

  • Paulina Gebhart,
  • Christian Singer,
  • Daniela Muhr,
  • Christina Stein and
  • Yen Y. Tan

Cowden syndrome (CS) is a rare hereditary disorder characterized by benign overgrowth in various tissues and a high risk of breast and thyroid cancer. CS is closely associated with pathogenic variants (PVs) in the phosphatase and tensin homolog (PTEN...

  • Case Report
  • Open Access
1,515 Views
7 Pages

Introduction: Acute abdominal pain is a prevalent complaint in pediatric emergency departments. Primary care physicians can find it challenging to treat such pain and, in particular, to determine whether it requires emergent surgical intervention. Ac...

  • Article
  • Open Access
3 Citations
2,938 Views
16 Pages

Supernumerary Teeth in the Anterior Maxilla of Non-Syndromic Children and Adolescents: A Retrospective Study Based on Cone-Beam Computed Tomography Scans

  • Antonis Lykousis,
  • Ioanna Pouliezou,
  • Nikolaos Christoloukas,
  • Aliki Rontogianni,
  • Anastasia Mitsea and
  • Christos Angelopoulos

Background/Objectives: The aim of this retrospective study was to investigate the supernumerary teeth located in the anterior region of the maxilla of non-syndromic Greek children and adolescents, as well as their possible correlation with demographi...

  • Article
  • Open Access
3,134 Views
14 Pages

Quality of Life and Psychological Functioning in Children with PFAPA Syndrome

  • Xosé Ramón García-Soto,
  • Maria Isabel Villanueva-Alameda,
  • Jessica Fernández-Solana,
  • Jerónimo J. González-Bernal,
  • Arancha Bernal-Jiménez,
  • Lara Santos-Martín,
  • Juan García-Mellado,
  • Sara Calvo-Simal and
  • Rodrigo Vélez-Santamaría

Background/Objectives: This study analyzes the impact of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) on health-related quality of life (HRQoL) and the psychological functioning of children and adolescents aged 2 to...

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Pediatr. Rep. - ISSN 2036-7503