Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review
Round 1
Reviewer 1 Report
Idiopathic intracranial hypertension is a neurological disorder characterized by optic disc swelling secondary to raised intracranial pressure of unknown cause. The manuscript, Micronutrient deficiencies presenting with optic disc swelling associated with or without intracranial hypertension: A systematic review, conducted a systematic search of articles published between 1 January 1980 and 18 December 2020 reporting cases of optic disc swelling associated with micronutrient deficiencies. The results suggest that patients with idiopathic intracranial hypertension or unexplained optic disc swelling ought to be screened, investigated, and treated for associated micronutrient deficiencies in vitamin A, B1 and B12; and weight loss interventions in idiopathic intracranial hypertension patients ought to promote better nutrition in addition to overall calorie restriction. The literature reviewed were comprehensive and systematic. The results could enrich the understanding of idiopathic intracranial hypertension. The overall research design is sound and solid, the results are convincing in general.
Author Response
Thank you for your time in reviewing this manusciript.
Reviewer 2 Report
It must be added and grouped also by clinical parameters
Add the results of CSFs and CTSCANs and MRIs.Improve the data and the statistical survey through more homogeneous groups for clinical data Also consider BMI and degree of obesity and distinguish patient group
Author Response
Please see attached
Author Response File: Author Response.docx