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Nutrients
Volume 14
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10.3390/nu14091868
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Article

Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet

by
Yanzhou Hu
1,
Jia Xu
1,
Yao Sheng
1,
Junyu Liu
1,
Haoyu Li
1,
Mingzhang Guo
1,
Wentao Xu
2,3,
Yunbo Luo
1,3,
Kunlun Huang
1,3,* and
Xiaoyun He
1,3,*
1
Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China
3
Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), The Ministry of Agriculture and Rural Affairs of the P.R. China, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Nutrients 2022, 14(9), 1868; https://doi.org/10.3390/nu14091868
Submission received: 21 March 2022 / Revised: 23 April 2022 / Accepted: 24 April 2022 / Published: 29 April 2022
(This article belongs to the Section Lipids)
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Abstract

Pleurotus ostreatus (PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating the gut microbiota, we administered the mice with a low-fat diet or high-fat diet containing different dosages of PO (mass fraction: 0%, 2.5%, 5% and 10%). The body weight, adipose tissue weight, GTT, ITT, blood lipids, serum biomarkers of liver/kidney function, the gut microbiota and function were measured and analyzed after 6 weeks of PO treatment. The results showed PO prevented obesity, maintained glucose homeostasis and beneficially modulated gut microbiota. PO modified the composition and functions of gut microbiota in obese mice and make them similar to those in lean mice, which contributed to weight loss. PO significantly increased the relative abundance of Oscillospira, Lactobacillus group and Bifidobacterium, while decreased the relative abundance of Bacteroides and Roseburia. The prediction of gut microbiota function showed PO upregulated lipid metabolism, carbohydrate metabolism, bile acid biosynthesis, while it downregulated adipocytokine signaling pathway and steroid hormone biosynthesis. Correlation analysis further suggested the potential relationship among obesity, gut microbiota and the function of gut microbiota. In conclusion, all the results indicated that PO ameliorated obesity at least partly by modulating the gut microbiota.
Keywords: Pleurotus Ostreatus; obesity; gut microbiota; 16S rRNA gene; PICRUSt algorithm Pleurotus Ostreatus; obesity; gut microbiota; 16S rRNA gene; PICRUSt algorithm

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MDPI and ACS Style

Hu, Y.; Xu, J.; Sheng, Y.; Liu, J.; Li, H.; Guo, M.; Xu, W.; Luo, Y.; Huang, K.; He, X. Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet. Nutrients 2022, 14, 1868. https://doi.org/10.3390/nu14091868

AMA Style

Hu Y, Xu J, Sheng Y, Liu J, Li H, Guo M, Xu W, Luo Y, Huang K, He X. Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet. Nutrients. 2022; 14(9):1868. https://doi.org/10.3390/nu14091868

Chicago/Turabian Style

Hu, Yanzhou, Jia Xu, Yao Sheng, Junyu Liu, Haoyu Li, Mingzhang Guo, Wentao Xu, Yunbo Luo, Kunlun Huang, and Xiaoyun He. 2022. "Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet" Nutrients 14, no. 9: 1868. https://doi.org/10.3390/nu14091868

APA Style

Hu, Y., Xu, J., Sheng, Y., Liu, J., Li, H., Guo, M., Xu, W., Luo, Y., Huang, K., & He, X. (2022). Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet. Nutrients, 14(9), 1868. https://doi.org/10.3390/nu14091868

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