Abstract
Plant Extracts (PE) are natural substances extracted from plants, rich in various bioactive components. Exploring the molecular mechanisms and interactions involved in the vascular protective effects of PE is beneficial for the development of further strategies to protect aging blood vessels. For this review, the content was obtained from scientific databases such as PubMed, China National Knowledge Infrastructure (CNKI), and Google Scholar up to July 2024, using the search terms “Plant extracts”, “oxidative stress”, “vascular aging”, “endothelial dysfunction”, “ROS”, and “inflammation”. This review highlighted the effects of PE in protecting aging blood vessels. Through pathways such as scavenging reactive oxygen species, activating antioxidant signaling pathways, enhancing respiratory chain complex activity, inhibiting mitochondrial-reactive oxygen species generation, improving nitric oxide bioavailability, downregulating the secretion of inflammatory factors, and activating sirtuins 1 and Nrf2 signaling pathways, it can improve vascular structural and functional changes caused by age-related oxidative stress, mitochondrial dysfunction, and inflammation due to aging, thereby reducing the incidence of age-related cardiovascular diseases.
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MDPI and ACS Style
Luo, Y.; Zhang, Z.; Zheng, W.; Zeng, Z.; Fan, L.; Zhao, Y.; Huang, Y.; Cao, S.; Yu, S.; Shen, L.
Molecular Mechanisms of Plant Extracts in Protecting Aging Blood Vessels. Nutrients 2024, 16, 2357.
https://doi.org/10.3390/nu16142357
AMA Style
Luo Y, Zhang Z, Zheng W, Zeng Z, Fan L, Zhao Y, Huang Y, Cao S, Yu S, Shen L.
Molecular Mechanisms of Plant Extracts in Protecting Aging Blood Vessels. Nutrients. 2024; 16(14):2357.
https://doi.org/10.3390/nu16142357
Chicago/Turabian Style
Luo, Yuxin, Zeru Zhang, Weijian Zheng, Zhi Zeng, Lei Fan, Yuquan Zhao, Yixin Huang, Suizhong Cao, Shumin Yu, and Liuhong Shen.
2024. "Molecular Mechanisms of Plant Extracts in Protecting Aging Blood Vessels" Nutrients 16, no. 14: 2357.
https://doi.org/10.3390/nu16142357
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