This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessBrief Report
Effectiveness of Combination of Tibolone and Lactobacilli Plus Lactoferrin in Postmenopausal Women with Vulvar Vestibular Pain: A Preliminary Report
by
Vincenzo De Leo
Vincenzo De Leo 1,*,
Laura Governini
Laura Governini 2,*
,
Rosetta Ponchia
Rosetta Ponchia 2,
Dario Recalcati
Dario Recalcati 3 and
Filippo Murina
Filippo Murina 3
1
Medical Office “Colledoro”, 53100 Siena, Italy
2
Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
3
Lower Genital Tract Disease Unit, V. Buzzi Hospital, University of the Study of Milan, 20124 Milan, Italy
*
Authors to whom correspondence should be addressed.
Nutrients 2024, 16(14), 2378; https://doi.org/10.3390/nu16142378 (registering DOI)
Submission received: 5 June 2024
/
Revised: 20 July 2024
/
Accepted: 21 July 2024
/
Published: 22 July 2024
Abstract
Background: Postmenopausal dyspareunia and vulvar pain are common complaints, affecting about 60% of women within a few years after hormone levels begin to decline (such as estrogen and androgen). Atrophic changes mainly located in the vulvar vestibule and vulnerability to vulvovaginal infections in postmenopause could be predisposing factors to the development of vulvar burning/pain and introital dyspareunia (vestibulodynia secondary to atrophy). Tibolone is the most effective and safe alternative for treating menopausal symptoms. The role of Lactobacilli and lactoferrin shows its effectiveness in the treatment of vaginal microbiota dysbiosis. The aim of the present study was to assess the efficacy of the combination of tibolone and an oral-specific Lactobacilli mixture in combination with bovine lactoferrin as synergistic therapy for the treatment of vestibulodynia related to atrophy. Methods: In this study, we included 35 postmenopausal women with at least 1 year of amenorrhea, affected by vulvar burning/pain and introital dyspareunia. All participants received treatment with open-label, oral Tibolone 2.5 mg and Lactobacilli mixture (5 × 109 CFU per capsule) in combination with bovine lactoferrin (Respecta®). Each product was taken once daily for 90 days. Results: After 90 d of therapy with TIB+ Respecta®, in 30 women that completed the treatment, there was a statistically significant decrease from the baseline in the mean of the Visual Analog Scale for vulvar burning/pain and a reduction in scores in the pain evaluation test. Conclusions: This study provides evidence that the combination of TIB+ Respecta® was effective in reducing symptoms related to vestibular pain and hypersensitivity in a postmenopausal setting.
Share and Cite
MDPI and ACS Style
De Leo, V.; Governini, L.; Ponchia, R.; Recalcati, D.; Murina, F.
Effectiveness of Combination of Tibolone and Lactobacilli Plus Lactoferrin in Postmenopausal Women with Vulvar Vestibular Pain: A Preliminary Report. Nutrients 2024, 16, 2378.
https://doi.org/10.3390/nu16142378
AMA Style
De Leo V, Governini L, Ponchia R, Recalcati D, Murina F.
Effectiveness of Combination of Tibolone and Lactobacilli Plus Lactoferrin in Postmenopausal Women with Vulvar Vestibular Pain: A Preliminary Report. Nutrients. 2024; 16(14):2378.
https://doi.org/10.3390/nu16142378
Chicago/Turabian Style
De Leo, Vincenzo, Laura Governini, Rosetta Ponchia, Dario Recalcati, and Filippo Murina.
2024. "Effectiveness of Combination of Tibolone and Lactobacilli Plus Lactoferrin in Postmenopausal Women with Vulvar Vestibular Pain: A Preliminary Report" Nutrients 16, no. 14: 2378.
https://doi.org/10.3390/nu16142378
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article metric data becomes available approximately 24 hours after publication online.