Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Participants
2.3. Ethical Considerations
2.4. Data Collection
2.5. Analysis of Hematochemical Parameters
2.6. Evaluation of the Antioxidative Effect
2.7. Liquid Chromatography SANIST Mass Spectrometry
2.8. Statistical Analysis
3. Results
3.1. Anthropometric, Hematochemical, Inflammatory and Oxidative Parameters
3.2. Mass Spectrometry Serum Characterization
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Jimenez-Lopez, C.; Carpena, M.; Lourenço-Lopes, C.; Gallardo-Gomez, M.; Lorenzo, J.M.; Barba, F.J.; Prieto, M.A.; Simal-Gandara, J. Bioactive Compounds and Quality of Extra Virgin Olive Oil. Foods 2020, 9, 1014. [Google Scholar] [CrossRef]
- Therdyothin, A.; Prokopidis, K.; Galli, F.; Witard, O.C.; Isanejad, M. The Effects of Omega-3 Polyunsaturated Fatty Acids on Muscle and Whole-Body Protein Synthesis: A Systematic Review and Meta-Analysis. Nutr. Rev. 2024, nuae055. [Google Scholar] [CrossRef] [PubMed]
- Lanza, B.; Ninfali, P. Antioxidants in Extra Virgin Olive Oil and Table Olives: Connections between Agriculture and Processing for Health Choices. Antioxidants 2020, 9, 41. [Google Scholar] [CrossRef] [PubMed]
- Flynn, M.M.; Tierney, A.; Itsiopoulos, C. Is Extra Virgin Olive Oil the Critical Ingredient Driving the Health Benefits of a Mediterranean Diet? A Narrative Review. Nutrients 2023, 15, 2916. [Google Scholar] [CrossRef] [PubMed]
- Rossi, M.; Caruso, F.; Kwok, L.; Lee, G.; Caruso, A.; Gionfra, F.; Candelotti, E.; Belli, S.L.; Molasky, N.; Raley-Susman, K.M.; et al. Protection by Extra Virgin Olive Oil against Oxidative Stress In Vitro and In Vivo. Chemical and Biological Studies on the Health Benefits Due to a Major Component of the Mediterranean Diet. PLoS ONE 2017, 12, e0189341. [Google Scholar] [CrossRef] [PubMed]
- Cuffaro, D.; Bertolini, A.; Bertini, S.; Ricci, C.; Cascone, M.G.; Danti, S.; Saba, A.; Macchia, M.; Digiacomo, M. Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties. Nutrients 2023, 15, 3746. [Google Scholar] [CrossRef]
- Ke, Y.; Fan, H.; Zhao, Y.; Fu, X.; Wang, M.; Gao, Y.; Chen, Y.; Huo, W.; Zhang, W.; Wang, L.; et al. Olive Oil Intake and Cardiovascular Disease, Cancer, and All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. Food Funct. 2024, 15, 4668–4681. [Google Scholar] [CrossRef]
- Zupo, R.; Castellana, F.; Crupi, P.; Desantis, A.; Rondanelli, M.; Corbo, F.; Clodoveo, M.L. Olive Oil Polyphenols Improve HDL Cholesterol and Promote Maintenance of Lipid Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Metabolites 2023, 13, 1187. [Google Scholar] [CrossRef]
- Tsamos, G.; Kalopitas, G.; Evripidou, K.; Vasdeki, D.; Koufakis, T.; Kanavas, V.; Antza, C.; Germanidis, G.; Chourdakis, M. The Effects of Olive Oil Consumption on Biochemical Parameters and Body Mass Index of People with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2024, 16, 857. [Google Scholar] [CrossRef]
- Marrero, A.D.; Quesada, A.R.; Martínez-Poveda, B.; Medina, M.Á. Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil. Nutrients 2024, 16, 1283. [Google Scholar] [CrossRef]
- Roberts, J.D.; Lillis, J.B.; Pinto, J.M.; Chichger, H.; López-Samanes, Á.; Coso, J.D.; Zacca, R.; Willmott, A.G.B. The Effect of a Hydroxytyrosol-Rich Olive-Derived Phytocomplex on Aerobic Exercise and Acute Recovery. Nutrients 2023, 15, 421. [Google Scholar] [CrossRef] [PubMed]
- Caponio, F.; Piga, A.; Poiana, M. Valorization of Food Processing By-Products. Foods 2022, 11, 3246. [Google Scholar] [CrossRef] [PubMed]
- Dini, I.; Graziani, G.; Fedele, F.L.; Sicari, A.; Vinale, F.; Castaldo, L.; Ritieni, A. An Environmentally Friendly Practice Used in Olive Cultivation Capable of Increasing Commercial Interest in Waste Products from Oil Processing. Antioxidants 2020, 9, 466. [Google Scholar] [CrossRef]
- Bellumori, M.; Cecchi, L.; Romani, A.; Mulinacci, N.; Innocenti, M. Recovery and Stability over Time of Phenolic Fractions by an Industrial Filtration System of Olive Mill Wastewaters: A Three-Year Study. J. Sci. Food Agric. 2018, 98, 2761–2769. [Google Scholar] [CrossRef]
- Krawczyk, M.; Burzynska-Pedziwiatr, I.; Wozniak, L.A.; Bukowiecka-Matusiak, M. Impact of Polyphenols on Inflammatory and Oxidative Stress Factors in Diabetes Mellitus: Nutritional Antioxidants and Their Application in Improving Antidiabetic Therapy. Biomolecules 2023, 13, 1402. [Google Scholar] [CrossRef]
- Williamson, G.; Sheedy, K. Effects of Polyphenols on Insulin Resistance. Nutrients 2020, 12, 3135. [Google Scholar] [CrossRef]
- Cho, A.R.; Kwon, Y.J.; Kim, J.K. Pre-Metabolic Syndrome and Incidence of Type 2 Diabetes and Hypertension: From the Korean Genome and Epidemiology Study. J. Pers. Med. 2021, 11, 700. [Google Scholar] [CrossRef]
- Vona, R.; Gambardella, L.; Cittadini, C.; Straface, E.; Pietraforte, D. Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases. Oxid. Med. Cell. Longev. 2019, 2019, 8267234. [Google Scholar] [CrossRef]
- Cristoni, S.; Rossi Bernardi, L.; Larini, M.; Natale, G.; Didomenico, N.; Varelli, M.; Conti, M.; Dorna, I.; Puccio, G. Predicting and Preventing Intestinal Dysbiosis on the Basis of Pharmacological Gut Microbiota Metabolism. Rapid Commun. Mass Spectrom. 2019, 33, 1221–1225. [Google Scholar] [CrossRef]
- Balashova, E.E.; Maslov, D.L.; Lokhov, P.G. A Metabolomics Approach to Pharmacotherapy Personalization. J. Pers. Med. 2018, 83, 28. [Google Scholar] [CrossRef]
- Maslov, D.; Balashova, E.; Lokhov, P.; Archakov, A.I. Pharmacometabonomics—The Novel Way to Personalized Drug Therapy. Biomeditsinskaya Khimiya 2017, 63, 115–123. [Google Scholar] [CrossRef] [PubMed]
- Ang, M.Y.; Low, T.Y.; Lee, P.Y.; Wan Mohamad Nazarie, W.F.; Guryev, V.; Jamal, R. Proteogenomics: From Next-Generation Sequencing (NGS) and Mass Spectrometry-Based Proteomics to Precision Medicine. Clin. Chim. Acta 2019, 498, 38–46. [Google Scholar] [CrossRef]
- Zinellu, E.; Zinellu, A.; Fois, A.G.; Carru, C.; Pirina, P. Circulating Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease: A Systematic Review. Respir. Res. 2016, 17, 150. [Google Scholar] [CrossRef] [PubMed]
- Qiu, S.; Cai, Y.; Yao, H.; Lin, C.; Xie, Y.; Tang, S.; Zhang, A. Small Molecule Metabolites: Discovery of Biomarkers and Therapeutic Targets. Signal Transduct. Target. Ther. 2023, 81, 132. [Google Scholar] [CrossRef]
- Demicheva, E.; Dordiuk, V.; Polanco Espino, F.; Ushenin, K.; Aboushanab, S.; Shevyrin, V.; Buhler, A.; Mukhlynina, E.; Solovyova, O.; Danilova, I.; et al. Advances in Mass Spectrometry-Based Blood Metabolomics Profiling for Non-Cancer Diseases: A Comprehensive Review. Metabolites 2024, 141, 54. [Google Scholar] [CrossRef]
- Albini, A.; Briga, D.; Conti, M.; Bruno, A.; Farioli, D.; Canali, S.; Sogno, I.; D’Ambrosio, G.; Consonni, P.; Noonan, D.M. SANIST: A Rapid Mass Spectrometric SACI/ESI Data Acquisition and Elaboration Platform for Verifying Potential Candidate Biomarkers. Rapid Commun. Mass Spectrom. 2015, 29, 1703–1710. [Google Scholar] [CrossRef]
- Albini, A.; Bruno, A.; Bassani, B.; D’Ambrosio, G.; Pelosi, G.; Consonni, P.; Castellani, L.; Conti, M.; Cristoni, S.; Noonan, D.M. Serum Steroid Ratio Profiles in Prostate Cancer: A New Diagnostic Tool Toward a Personalized Medicine Approach. Front. Endocrinol. 2018, 9, 110. [Google Scholar] [CrossRef] [PubMed]
- Cristoni, S.; Dusi, G.; Brambilla, P.; Albini, A.; Conti, M.; Brambilla, M.; Bruno, A.; Di Gaudio, F.; Ferlin, L.; Tazzari, V.; et al. SANIST: Optimization of a Technology for Compound Identification Based on the European Union Directive with Applications in Forensic Pharmaceutical and Food Analyses. J. Mass Spectrom. 2017, 52, 16–21. [Google Scholar] [CrossRef] [PubMed]
- Cristoni, S.; Molin, L.; Lai, A.; Bernardi, L.R.; Pucciarelli, S.; Agostini, M.; Bedin, C.; Nitti, D.; Seraglia, R.; Repetto, O.; et al. MALDI-MS-NIST Library Approach for Colorectal Cancer Diagnosis. Rapid Commun. Mass Spectrom. 2009, 23, 2839–2845. [Google Scholar] [CrossRef]
- Albini, A.; Albini, F.; Corradino, P.; Dugo, L.; Calabrone, L.; Noonan, D.M. From Antiquity to Contemporary Times: How Olive Oil By-Products and Waste Water Can Contribute to Health. Front. Nutr. 2023, 10, 1254947. [Google Scholar] [CrossRef]
- Peri, S.; Ruzzolini, J.; Urciuoli, S.; Versienti, G.; Biagioni, A.; Andreucci, E.; Peppicelli, S.; Bianchini, F.; Bottari, A.; Calorini, L.; et al. An Oleocanthal-Enriched EVO Oil Extract Induces ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy. Antioxidants 2022, 11, 1762. [Google Scholar] [CrossRef] [PubMed]
- Lăcătușu, C.M.; Grigorescu, E.D.; Floria, M.; Onofriescu, A.; Mihai, B.M. The Mediterranean Diet: From an Environment-Driven Food Culture to an Emerging Medical Prescription. Int. J. Environ. Res. Public Health 2019, 16, 942. [Google Scholar] [CrossRef] [PubMed]
- Santangelo, C.; Vari, R.; Scazzocchio, B.; De Sanctis, P.; Giovannini, C.; D’Archivio, M.; Masella, R. Anti-Inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases? Endocr. Metab. Immune Disord. Drug Targets 2018, 18, 36–50. [Google Scholar] [CrossRef] [PubMed]
- Nocella, C.; Cammisotto, V.; Fianchini, L.; D’Amico, A.; Novo, M.; Castellani, V.; Stefanini, L.; Violi, F.; Carnevale, R. Extra Virgin Olive Oil and Cardiovascular Diseases: Benefits for Human Health. Endocr. Metab. Immune Disord. Drug Targets 2018, 18, 4–13. [Google Scholar] [CrossRef] [PubMed]
- Billingsley, H.E.; Carbone, S.; Lavie, C.J. Dietary Fats and Chronic Noncommunicable Diseases. Nutrients 2018, 10, 1385. [Google Scholar] [CrossRef]
- Tsao, R. Chemistry and Biochemistry of Dietary Polyphenols. Nutrients 2010, 2, 1231–1246. [Google Scholar] [CrossRef]
- Stagos, D. Antioxidant Activity of Polyphenolic Plant Extracts. Antioxidants 2019, 9, 19. [Google Scholar] [CrossRef]
- Rudrapal, M.; Khairnar, S.J.; Khan, J.; Dukhyil, A.B.; Ansari, M.A.; Alomary, M.N.; Palai, S.; Deb, P.K.; Devi, R. Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights into Protective Effects, Antioxidant Potentials, and Mechanism(s) of Action. Front. Pharmacol. 2022, 13, 806470. [Google Scholar] [CrossRef]
- Bhuyan, U.; Handique, J.G. Plant Polyphenols as Potent Antioxidants: Highlighting the Mechanism of Antioxidant Activity and Synthesis/Development of Some Polyphenol Conjugates. Stud. Nat. Prod. Chem. 2022, 75, 243–266. [Google Scholar] [CrossRef]
- Selim, S.; Albqmi, M.; Al-Sanea, M.M.; Alnusaire, T.S.; Almuhayawi, M.S.; AbdElgawad, H.; Al Jaouni, S.K.; Elkelish, A.; Hussein, S.; Warrad, M.; et al. Valorizing the Usage of Olive Leaves Bioactive Compounds, Biological Activities, and Food Applications: A Comprehensive Review. Front. Nutr. 2022, 9, 1008349. [Google Scholar] [CrossRef]
- Otero, C.; Miranda-Rojas, S.; Llancalahuén, F.M.; Fuentes, J.A.; Atala, C.; González-Silva, G.; Verdugo, D.; Sierra-Rosales, P.; Moreno, A.; Gordillo-Fuenzalida, F. Biochemical Characterization of Peumus Boldus Fruits: Insights of Its Antioxidant Properties through a Theoretical Approach. Food Chem. 2022, 370, 131012. [Google Scholar] [CrossRef] [PubMed]
- Khwaldia, K.; Attour, N.; Matthes, J.; Beck, L.; Schmid, M. Olive Byproducts and Their Bioactive Compounds as a Valuable Source for Food Packaging Applications. Compr. Rev. Food Sci. Food Saf. 2022, 21, 1218–1253. [Google Scholar] [CrossRef]
- Vauzour, D.; Rodriguez-Mateos, A.; Corona, G.; Oruna-Concha, M.J.; Spencer, J.P. Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action. Nutrients 2010, 2, 1106–1131. [Google Scholar] [CrossRef] [PubMed]
- Bahadoran, Z.; Mirmiran, P.; Azizi, F. Dietary Polyphenols as Potential Nutraceuticals in Management of Diabetes: A Review. J. Diabetes Metab. Disord. 2013, 12, 43. [Google Scholar] [CrossRef]
- Cory, H.; Passarelli, S.; Szeto, J.; Tamez, M.; Mattei, J. The Role of Polyphenols in Human Health and Food Systems: A Mini-Review. Front. Nutr. 2018, 5, 87. [Google Scholar] [CrossRef]
- Castañer, O.; Covas, M.I.; Khymenets, O.; Nyyssonen, K.; Konstantinidou, V.; Zunft, H.F.; de la Torre, R.; Muñoz-Aguayo, D.; Vila, J.; Fitó, M. Protection of LDL from Oxidation by Olive Oil Polyphenols Is Associated with a Downregulation of CD40-Ligand Expression and Its Downstream Products in Vivo in Humans. Am. J. Clin. Nutr. 2012, 95, 1238–1244. [Google Scholar] [CrossRef] [PubMed]
- Mancini, J.G.; Filion, K.B.; Atallah, R.; Eisenberg, M.J. Systematic Review of the Mediterranean Diet for Long-Term Weight Loss. Am. J. Med. 2016, 129, 407–415.e4. [Google Scholar] [CrossRef]
- Flynn, M.M.; Reinert, S.E. Comparing an Olive Oil-Enriched Diet to a Standard Lower-Fat Diet for Weight Loss in Breast Cancer Survivors: A Pilot Study. J. Womens Health 2010, 19, 1155–1161. [Google Scholar] [CrossRef]
- Nishi, S.K.; Babio, N.; Paz-Graniel, I.; Serra-Majem, L.; Vioque, J.; Fitó, M.; Corella, D.; Pintó, X.; Bueno-Cavanillas, A.; Tur, J.A.; et al. Water Intake, Hydration Status, and 2-Year Changes in Cognitive Performance: A Prospective Cohort Study. BMC Med. 2023, 21, 82. [Google Scholar] [CrossRef]
- Li, S.; Xiao, X.; Zhang, X. Hydration Status in Older Adults: Current Knowledge and Future Challenges. Nutrients 2023, 15, 2609. [Google Scholar] [CrossRef]
- Caruso, C.; Accardi, G.; Virruso, C.; Candore, G. Sex, Gender, and Immunosenescence: A Key to Understand the Different Lifespan between Men and Women? Immun. Ageing 2013, 10, 20. [Google Scholar] [CrossRef]
- de Brito Alves, J.L.; de Sousa, V.P.; Cavalcanti Neto, M.P.; Magnani, M.; Braga, V.A.; da Costa-Silva, J.H.; Leandro, C.G.; Vidal, H.; Pirola, L. New Insights on the Use of Dietary Polyphenols or Probiotics for the Management of Arterial Hypertension. Front. Physiol. 2016, 7, 448. [Google Scholar] [CrossRef] [PubMed]
- Barona, J.; Jones, J.J.; Kopec, R.E.; Comperatore, M.; Andersen, C.; Schwartz, S.J.; Lerman, R.H.; Fernandez, M.L. A Mediterranean-Style Low-Glycemic-Load Diet Increases Plasma Carotenoids and Decreases LDL Oxidation in Women with Metabolic Syndrome. J. Nutr. Biochem. 2012, 23, 609–615. [Google Scholar] [CrossRef] [PubMed]
- Sarapis, K.; Thomas, C.J.; Hoskin, J.; George, E.S.; Marx, W.; Mayr, H.L.; Kennedy, G.; Pipingas, A.; Willcox, J.C.; Prendergast, L.A.; et al. The Effect of High Polyphenol Extra Virgin Olive Oil on Blood Pressure and Arterial Stiffness in Healthy Australian Adults: A Randomized Controlled Cross-Over Study. Nutrients 2020, 12, 2272. [Google Scholar] [CrossRef]
- Moreno-Luna, R.; Muñoz-Hernandez, R.; Miranda, M.L.; Costa, A.F.; Jimenez-Jimenez, L.; Vallejo-Vaz, A.J.; Muriana, F.J.; Villar, J.; Stiefel, P. Olive Oil Polyphenols Decrease Blood Pressure and Improve Endothelial Function in Young Women with Mild Hypertension. Am. J. Hypertens. 2012, 25, 1299–1304. [Google Scholar] [CrossRef] [PubMed]
- Violi, F.; Loffredo, L.; Pignatelli, P.; Angelico, F.; Bartimoccia, S.; Nocella, C.; Cangemi, R.; Petruccioli, A.; Monticolo, R.; Pastori, D.; et al. Extra Virgin Olive Oil Use Is Associated with Improved Post-Prandial Blood Glucose and LDL Cholesterol in Healthy Subjects. Nutr. Diabetes 2015, 5, e172. [Google Scholar] [CrossRef]
- Vigneri, R.; Sciacca, L.; Vigneri, P. Rethinking the Relationship between Insulin and Cancer. Trends Endocrinol. Metab. 2020, 31, 551–560. [Google Scholar] [CrossRef]
- Bertoli, A.; Valentini, A.; Cianfarani, M.A.; Gasbarra, E.; Tarantino, U.; Federici, M. Low FT3: A Possible Marker of Frailty in the Elderly. Clin. Interv. Aging 2017, 12, 335–341. [Google Scholar] [CrossRef]
- Alì, S.; Davinelli, S.; Accardi, G.; Aiello, A.; Caruso, C.; Duro, G.; Ligotti, M.E.; Pojero, F.; Scapagnini, G.; Candore, G. Healthy Ageing and Mediterranean Diet: A Focus on Hormetic Phytochemicals. Mech. Ageing Dev. 2021, 200, 111592. [Google Scholar] [CrossRef]
- Roche, M.; Rondeau, P.; Singh, N.R.; Tarnus, E.; Bourdon, E. The Antioxidant Properties of Serum Albumin. FEBS Lett. 2008, 582, 1783–1787. [Google Scholar] [CrossRef]
- Belinskaia, D.A.; Voronina, P.A.; Shmurak, V.I.; Jenkins, R.O.; Goncharov, N.V. Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting, and Signaling Properties. Int. J. Mol. Sci. 2021, 22, 10318. [Google Scholar] [CrossRef] [PubMed]
- Sitar, M.E.; Aydin, S.; Cakatay, U. Human Serum Albumin and Its Relation with Oxidative Stress. Clin. Lab 2013, 59, 945–952. [Google Scholar] [CrossRef] [PubMed]
- Eckart, A.; Struja, T.; Kutz, A.; Baumgartner, A.; Baumgartner, T.; Zurfluh, S.; Neeser, O.; Huber, A.; Stanga, Z.; Mueller, B.; et al. Relationship of Nutritional Status, Inflammation, and Serum Albumin Levels during Acute Illness: A Prospective Study. Am. J. Med. 2020, 133, 713–722.e7. [Google Scholar] [CrossRef] [PubMed]
- Rozga, J.; Piątek, T.; Małkowski, P. Human Albumin: Old, New, and Emerging Applications. Ann. Transplant. 2013, 18, 205–217. [Google Scholar] [CrossRef] [PubMed]
- Jun, J.E.; Lee, S.E.; Lee, Y.B.; Jee, J.H.; Bae, J.C.; Jin, S.M.; Hur, K.Y.; Lee, M.K.; Kim, J.H. Increase in Serum Albumin Concentration Is Associated with Prediabetes Development and Progression to Overt Diabetes Independently of Metabolic Syndrome. PLoS ONE 2017, 12, e0176209. [Google Scholar] [CrossRef]
- Morris, A.; Krishnan, N.; Kimani, P.K.; Lycett, D. Effect of Dietary Potassium Restriction on Serum Potassium, Disease Progression, and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. J. Ren. Nutr. 2020, 30, 276–285. [Google Scholar] [CrossRef]
- Picard, K.; Barreto Silva, M.I.; Mager, D.; Richard, C. Dietary Potassium Intake and Risk of Chronic Kidney Disease Progression in Predialysis Patients with Chronic Kidney Disease: A Systematic Review. Adv. Nutr. 2020, 11, 1002–1015. [Google Scholar] [CrossRef]
- Pourafshar, S.; Sharma, B.; Kranz, S.; Mallawaarachchi, I.; Kurland, E.; Ma, J.Z.; Scialla, J.J. Patterns of Fruit and Vegetable Intake in Adults with and without Chronic Kidney Disease in the United States. J. Ren. Nutr. 2023, 33, 88–96. [Google Scholar] [CrossRef]
- Berridge, M.J. Vitamin D, Reactive Oxygen Species, and Calcium Signalling in Ageing and Disease. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2016, 371, 20150434. [Google Scholar] [CrossRef]
- Della Nera, G.; Sabatino, L.; Gaggini, M.; Gorini, F.; Vassalle, C. Vitamin D Determinants, Status, and Antioxidant/Anti-Inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy. Antioxidants 2023, 12, 948. [Google Scholar] [CrossRef]
- Masjedi, F.; Keshtgar, S.; Zal, F.; Talaei-Khozani, T.; Sameti, S.; Fallahi, S.; Kazeroni, M. Effects of Vitamin D on Steroidogenesis, Reactive Oxygen Species Production, and Enzymatic Antioxidant Defense in Human Granulosa Cells of Normal and Polycystic Ovaries. J. Steroid Biochem. Mol. Biol. 2020, 197, 105521. [Google Scholar] [CrossRef] [PubMed]
- Quigley, M.; Rieger, S.; Capobianco, E.; Wang, Z.; Zhao, H.; Hewison, M.; Lisse, T.S. Vitamin D Modulation of Mitochondrial Oxidative Metabolism and mTOR Enforces Stress Adaptations and Anticancer Responses. JBMR Plus 2021, 6, e10572. [Google Scholar] [CrossRef]
- McCourt, A.F.; O’Sullivan, A.M. Using Food Fortification to Improve Vitamin D Bioaccessibility and Intakes. Proc. Nutr. Soc. 2022, 81, 99–107. [Google Scholar] [CrossRef] [PubMed]
- Pu, F.; Chen, N.; Xue, S. Calcium Intake, Calcium Homeostasis, and Health. Food Sci. Hum. Wellness 2016, 5, 8–16. [Google Scholar] [CrossRef]
- Beto, J.A. The Role of Calcium in Human Aging. Clin. Nutr. Res. 2015, 4, 1–8. [Google Scholar] [CrossRef]
- Veldurthy, V.; Wei, R.; Oz, L.; Dhawan, P.; Jeon, Y.H.; Christakos, S. Vitamin D, Calcium Homeostasis, and Aging. Bone Res. 2016, 4, 16041. [Google Scholar] [CrossRef]
- Wicher, S.A.; Roos, B.B.; Teske, J.J.; Fang, Y.H.; Pabelick, C.; Prakash, Y.S. Aging Increases Senescence, Calcium Signaling, and Extracellular Matrix Deposition in Human Airway Smooth Muscle. PLoS ONE 2021, 16, e0254710. [Google Scholar] [CrossRef]
- Shen, W.; Gao, C.; Cueto, R.; Liu, L.; Fu, H.; Shao, Y.; Yang, W.Y.; Fang, P.; Choi, E.T.; Wu, Q.; et al. Homocysteine-Methionine Cycle Is a Metabolic Sensor System Controlling Methylation-Regulated Pathological Signaling. Redox Biol. 2020, 28, 101322. [Google Scholar] [CrossRef] [PubMed]
- Cristoni, S.; Bernardi, L.R.; Malvandi, A.M.; Larini, M.; Longhi, E.; Sortino, F.; Conti, M.; Pantano, N.; Puccio, G. A Case of Personalized and Precision Medicine: Pharmacometabolomic Applications to Rare Cancer, Microbiological Investigation, and Therapy. Rapid Commun. Mass Spectrom. 2021, 35, e8976. [Google Scholar] [CrossRef]
- Brattström, L.; Wilcken, D.E. Homocysteine and Cardiovascular Disease: Cause or Effect? Am. J. Clin. Nutr. 2000, 72, 315–323. [Google Scholar] [CrossRef]
- Dinavahi, R.; Falkner, B. Relationship of Homocysteine with Cardiovascular Disease and Blood Pressure. J. Clin. Hypertens. 2004, 6, 494–498. [Google Scholar] [CrossRef] [PubMed]
- Yuan, S.; Mason, A.M.; Carter, P.; Burgess, S.; Larsson, S.C. Homocysteine, B Vitamins, and Cardiovascular Disease: A Mendelian Randomization Study. BMC Med. 2021, 19, 97. [Google Scholar] [CrossRef]
- Guieu, R.; Ruf, J.; Mottola, G. Hyperhomocysteinemia and Cardiovascular Diseases. Ann. Biol. Clin. 2022, 80, 7–14. [Google Scholar] [CrossRef]
- Kumar, A.; Palfrey, H.A.; Pathak, R.; Kadowitz, P.J.; Gettys, T.W.; Murthy, S.N. The Metabolism and Significance of Homocysteine in Nutrition and Health. Nutr. Metab. 2017, 14, 78. [Google Scholar] [CrossRef] [PubMed]
- Nagayama, D.; Watanabe, Y.; Yamaguchi, T.; Suzuki, K.; Saiki, A.; Fujishiro, K.; Shirai, K. Issue of Waist Circumference for the Diagnosis of Metabolic Syndrome Regarding Arterial Stiffness: Possible Utility of a Body Shape Index in Middle-Aged Nonobese Japanese Urban Residents Receiving Health Screening. Obes. Facts 2022, 15, 160–169. [Google Scholar] [CrossRef]
- Mehmood, A.; Usman, M.; Patil, P.; Zhao, L.; Wang, C. A Review on Management of Cardiovascular Diseases by Olive Polyphenols. Food Sci. Nutr. 2020, 8, 4639–4655. [Google Scholar] [CrossRef]
- Branco, A.C.C.C.; Yoshikawa, F.S.Y.; Pietrobon, A.J.; Sato, M.N. Role of Histamine in Modulating the Immune Response and Inflammation. Mediators Inflamm. 2018, 2018, 9524075. [Google Scholar] [CrossRef]
- Thangam, E.B.; Jemima, E.A.; Singh, H.; Baig, M.S.; Khan, M.; Mathias, C.B.; Church, M.K.; Saluja, R. The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets. Front. Immunol. 2018, 9, 1873. [Google Scholar] [CrossRef]
- Carthy, E.; Ellender, T. Histamine, Neuroinflammation, and Neurodevelopment: A Review. Front. Neurosci. 2021, 15, 680214. [Google Scholar] [CrossRef]
- Murdaca, G.; Allegra, A.; Tonacci, A.; Musolino, C.; Ricciardi, L.; Gangemi, S. Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases. Biomedicines 2022, 10, 1877. [Google Scholar] [CrossRef]
- Mehrani, Y.; Morovati, S.; Tieu, S.; Karimi, N.; Javadi, H.; Vanderkamp, S.; Sarmadi, S.; Tajik, T.; Kakish, J.E.; Bridle, B.W.; et al. Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens. Cells 2023, 12, 2271. [Google Scholar] [CrossRef] [PubMed]
- Caruso, C.; Passarino, G.; Puca, A.; Scapagnini, G. “Positive biology”: The centenarian lesson. Immun. Ageing 2012, 9, 5. [Google Scholar] [CrossRef] [PubMed]
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Aiello, A.; Calabrone, L.; Noonan, D.M.; Corradino, P.; Nofri, S.; Cristoni, S.; Accardi, G.; Candore, G.; Caruso, C.; Zinellu, A.; et al. Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters. Nutrients 2024, 16, 3068. https://doi.org/10.3390/nu16183068
Aiello A, Calabrone L, Noonan DM, Corradino P, Nofri S, Cristoni S, Accardi G, Candore G, Caruso C, Zinellu A, et al. Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters. Nutrients. 2024; 16(18):3068. https://doi.org/10.3390/nu16183068
Chicago/Turabian StyleAiello, Anna, Luana Calabrone, Douglas M. Noonan, Paola Corradino, Sara Nofri, Simone Cristoni, Giulia Accardi, Giuseppina Candore, Calogero Caruso, Angelo Zinellu, and et al. 2024. "Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters" Nutrients 16, no. 18: 3068. https://doi.org/10.3390/nu16183068