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Micromachines, Volume 9, Issue 3

2018 March - 47 articles

Cover Story: Circulating tumor cells (CTCs) are regarded as a strong biomarker which includes clinically valuable information. However, CTCs are very rare and require precise separation and detection for effective clinical applications. In this paper, we report a flow-restricted microfluidic trap array capable of deterministic single-cell capture of CTCs. The single-CTC capturing ability not only showed cell enumerating ability but also high prospects for application in future automated downstream analysis. View this paper
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Articles (47)

  • Article
  • Open Access
17 Citations
6,864 Views
11 Pages

Dielectrophoretic Microfluidic Device for in Vitro Fertilization

  • Hong-Yuan Huang,
  • Yun-Li Lai and
  • Da-Jeng Yao

20 March 2018

The aim of this work was to create a microfluidic platform that uses in vitro fertilization (IVF) and avoids unnecessary damage to oocytes due to the dielectrophoretic force manipulation of the sperms and oocytes that occurs in a traditional IVF oper...

  • Review
  • Open Access
24 Citations
6,747 Views
10 Pages

Optofluidics Refractometers

  • Cheng Li,
  • Gang Bai,
  • Yunxiao Zhang,
  • Min Zhang and
  • Aoqun Jian

20 March 2018

Refractometry is a classic analytical method in analytical chemistry and biosensing. By integrating advanced micro- and nano-optical systems with well-developed microfluidics technology, optofluidics are shown to be a powerful, smart and universal pl...

  • Article
  • Open Access
14 Citations
4,820 Views
15 Pages

20 March 2018

This paper presents an optimization-based design method of passive micromixers for immiscible fluids, which means that the Peclet number infinitely large. Based on topology optimization method, an optimization model is constructed to find the optimal...

  • Feature Paper
  • Article
  • Open Access
8 Citations
6,212 Views
9 Pages

20 March 2018

Through via holes in fused silica are a key infrastructure element of microwave and millimeter-wave circuits and 3D integration. In this work, etching through via holes in ultra-thin fused silica wafers using deep reactive-ion etching (DRIE) and lase...

  • Article
  • Open Access
27 Citations
7,613 Views
10 Pages

Single-Wall Carbon Nanotube-Coated Cotton Yarn for Electrocardiography Transmission

  • Yuliang Zhao,
  • Yuying Cao,
  • Junshan Liu,
  • Zhikun Zhan,
  • Xiaoli Li and
  • Wen Jung Li

19 March 2018

We fabricated a type of conductive fabric, specifically single-wall carbon nanotube-coated cotton yarns (SWNT-CYs), for electrocardiography (ECG) signal transmission utilizing a “dipping and drying” method. The conductive cotton yarns were prepared b...

  • Article
  • Open Access
12 Citations
4,847 Views
9 Pages

Fabrication and Study of Micro Monolithic Tungsten Ball Tips for Micro/Nano-CMM Probes

  • Ruijun Li,
  • Chen Chen,
  • Kuangchao Fan,
  • Zhiwei Wang,
  • Fangfang Liu and
  • Qiangxian Huang

19 March 2018

Micro ball tips with high precision, small diameter, and high stiffness stems are required to measure microstructures with high aspect ratio. Existing ball tips cannot meet such demands because of their weak qualities. This study used an arc-discharg...

  • Article
  • Open Access
5 Citations
4,918 Views
13 Pages

Modeling and Analysis of an Opto-Fluidic Sensor for Lab-on-a-Chip Applications

  • Venkatesha Muniswamy,
  • Chaya Bangalore Muniraju,
  • Prasant Kumar Pattnaik and
  • Narayan Krishnaswamy

19 March 2018

In this work modeling and analysis of an integrated opto-fluidic sensor, with a focus on achievement of single mode optical confinement and continuous flow of microparticles in the microfluidic channel for lab-on-a-chip (LOC) sensing application is p...

  • Article
  • Open Access
16 Citations
8,612 Views
14 Pages

16 March 2018

Bidirectional neural interfaces for multi-channel, high-density recording and electrical stimulation of neural activity in the central nervous system are fundamental tools for neuroscience and medical applications. Especially for clinical use, these...

  • Article
  • Open Access
20 Citations
5,312 Views
15 Pages

A Label Free Disposable Device for Rapid Isolation of Rare Tumor Cells from Blood by Ultrasounds

  • Itziar González,
  • Julie Earl,
  • Luis J. Fernández,
  • Bruno Sainz,
  • Alberto Pinto,
  • Rosa Monge,
  • Sonia Alcalá,
  • Adela Castillejo,
  • Jose L. Soto and
  • Alfredo Carrato

15 March 2018

The use of blood samples as liquid biopsy is a label-free method for cancer diagnosis that offers benefits over traditional invasive biopsy techniques. Cell sorting by acoustic waves offers a means to separate rare cells from blood samples based on t...

  • Article
  • Open Access
15 Citations
5,424 Views
8 Pages

15 March 2018

For the MEMS capacitive accelerometer, parasitic capacitance is a serious problem. Its mismatch will deteriorate the performance of accelerometer. Obtaining the mismatch of the parasitic capacitance precisely is helpful for improving the performance...

  • Article
  • Open Access
6 Citations
7,494 Views
12 Pages

15 March 2018

This paper reports the analysis of the crack configuration of a stretched metal conductive track that is embedded in a stretchable elastomer. The factor determining the crack configurations is analyzed by modeling as well as experiments. The modeling...

  • Feature Paper
  • Communication
  • Open Access
42 Citations
8,098 Views
10 Pages

14 March 2018

We have developed a sequential stereolithographic co-printing process using two different resins for fabricating porous barriers in microfluidic devices. We 3D-printed microfluidic channels with a resin made of poly(ethylene glycol) diacrylate (MW =...

  • Article
  • Open Access
24 Citations
10,780 Views
19 Pages

Micro-UFO (Untethered Floating Object): A Highly Accurate Microrobot Manipulation Technique

  • Hüseyin Uvet,
  • Ali Anil Demircali,
  • Yusuf Kahraman,
  • Rahmetullah Varol,
  • Tunc Kose and
  • Kadir Erkan

14 March 2018

A new microrobot manipulation technique with high precision (nano level) positional accuracy to move in a liquid environment with diamagnetic levitation is presented. Untethered manipulation of microrobots by means of externally applied magnetic forc...

  • Article
  • Open Access
32 Citations
6,973 Views
16 Pages

14 March 2018

ZrO2 ceramics are currently used in a broad range of industrial applications. However, the machining of post-sintered ZrO2 ceramic is a difficult task, due to its high hardness and brittleness. In this study, micro-milling of ZrO2 with two kinds of d...

  • Article
  • Open Access
3 Citations
5,927 Views
12 Pages

12 March 2018

Polymer microstructures are widely used in optics, flexible electronics, and so forth. We demonstrate a cost-effective bottom-up manner for patterning polymer microstructures by evaporative self-assembly under a flexible geometric confinement at a hi...

  • Article
  • Open Access
25 Citations
5,762 Views
14 Pages

10 March 2018

Selective enrichment of target species is crucial for a wide variety of engineering systems for improved performance of subsequent processes. Dielectrophoresis (DEP) is a powerful electrokinetic method that can be used to focus, trap, concentrate, an...

  • Article
  • Open Access
12 Citations
7,459 Views
15 Pages

Design, Fabrication, and Performance Characterization of LTCC-Based Capacitive Accelerometers

  • Huan Liu,
  • Runiu Fang,
  • Min Miao,
  • Yichuan Zhang,
  • Yingzhan Yan,
  • Xiaoping Tang,
  • Huixiang Lu and
  • Yufeng Jin

9 March 2018

In this paper, two versions of capacitive accelerometers based on low-temperature co-fired ceramic (LTCC) technology are developed, different with respect to the detection technique, as well as the mechanical structure. Fabrication of the key structu...

  • Article
  • Open Access
28 Citations
9,886 Views
18 Pages

9 March 2018

Micro-electromechanical system (MEMS) magnetic sensors are widely used in the nanosatellites field. We proposed a novel high-precision miniaturized three-axis digital tunneling magnetic resistance-type (TMR) sensor. The design of the three-axis digit...

  • Review
  • Open Access
18 Citations
7,720 Views
14 Pages

9 March 2018

Optofluidic microcavities with high Q factor have made rapid progress in recent years by using various micro-structures. On one hand, they are applied to microfluidic lasers with low excitation thresholds. On the other hand, they inspire the innovati...

  • Article
  • Open Access
58 Citations
10,440 Views
11 Pages

Highly Fluorinated Methacrylates for Optical 3D Printing of Microfluidic Devices

  • Frederik Kotz,
  • Patrick Risch,
  • Dorothea Helmer and
  • Bastian E. Rapp

8 March 2018

Highly fluorinated perfluoropolyether (PFPE) methacrylates are of great interest for transparent and chemically resistant microfluidic chips. However, so far only a few examples of material formulations for three-dimensional (3D) printing of these po...

  • Technical Note
  • Open Access
31 Citations
9,393 Views
11 Pages

Characterization of 3D-Printed Moulds for Soft Lithography of Millifluidic Devices

  • Nurul Mohd Fuad,
  • Megan Carve,
  • Jan Kaslin and
  • Donald Wlodkowic

8 March 2018

Increased demand for inexpensive and rapid prototyping methods for micro- and millifluidic lab-on-a-chip (LOC) devices has stimulated considerable interest in alternative cost-effective fabrication techniques. Additive manufacturing (AM)—also called...

  • Article
  • Open Access
32 Citations
5,174 Views
8 Pages

8 March 2018

Wear debris in hydraulic oil contains important information on the operation of equipment, which is important for condition monitoring and fault diagnosis in mechanical equipment. A micro inductive sensor based on the inductive coulter principle is p...

  • Article
  • Open Access
11 Citations
5,053 Views
15 Pages

8 March 2018

Our group has reported that Melan-A cells and lymphocytes undergo self-rotation in a homogeneous AC electric field, and found that the rotation velocity of these cells is a key indicator to characterize their physical properties. However, the determi...

  • Article
  • Open Access
57 Citations
6,816 Views
18 Pages

8 March 2018

This paper proposes an operation safety early warning system based on LabView (2014, National Instruments Corporation, Austin, TX, USA) for vascular interventional surgery (VIS) robotic system. The system not only provides intuitive visual feedback i...

  • Article
  • Open Access
6 Citations
5,707 Views
11 Pages

7 March 2018

To improve the reference potential stability of on-chip amperometric sensors, we propose a novel integrated Ag/AgCl reference electrode structure. This structure can refresh the saturated potassium chloride filling solution surrounding the Ag/AgCl el...

  • Article
  • Open Access
4 Citations
4,678 Views
25 Pages

6 March 2018

This paper proposes an adaptive absolute ego-motion estimation method using wearable visual-inertial sensors for indoor positioning. We introduce a wearable visual-inertial device to estimate not only the camera ego-motion, but also the 3D motion of...

  • Editorial
  • Open Access
2,832 Views
2 Pages

5 March 2018

Wireless microdevices are getting smaller and smaller, and in this special issue seven papers address a few miniaturization challenges in the biomedical field, which are common across different applications. Kargaran et al. [1] proposes a new ultra-l...

  • Article
  • Open Access
21 Citations
5,104 Views
18 Pages

4 March 2018

In order to maximize the mixing performance of a micromixer with an integrated three-dimensional serpentine and split-and-recombination configuration, multi-objective optimizations were performed at two different Reynolds numbers, 1 and 120, based on...

  • Article
  • Open Access
15 Citations
5,319 Views
22 Pages

Modeling and Closed Loop Flight Testing of a Fixed Wing Micro Air Vehicle

  • Harikumar Kandath,
  • Jinraj V. Pushpangathan,
  • Titas Bera,
  • Sidhant Dhall and
  • M. Seetharama Bhat

4 March 2018

This paper presents the nonlinear six degrees of freedom dynamic modeling of a fixed wing micro air vehicle. The static derivatives of the micro air vehicle are obtained through the wind tunnel testing. The propeller effects on the lift, drag, pitchi...

  • Article
  • Open Access
7 Citations
5,687 Views
10 Pages

Deterministic Capture of Individual Circulating Tumor Cells Using a Flow-Restricted Microfluidic Trap Array

  • Yousang Yoon,
  • Jusin Lee,
  • Ki-Chun Yoo,
  • Onejae Sul,
  • Su-Jae Lee and
  • Seung-Beck Lee

2 March 2018

Circulating tumor cells (CTCs) are regarded as a strong biomarker which includes clinically valuable information. However, CTCs are very rare and require precise separation and detection for effective clinical applications. Furthermore, downstream an...

  • Article
  • Open Access
87 Citations
8,853 Views
11 Pages

2 March 2018

In this numerical study, a new type of serpentine micromixer involving mixing units with a non-rectangular cross-section is investigated. Similar to other serpentine/spiral shaped micromixers, the design exploits the formation of transversal vortices...

  • Article
  • Open Access
46 Citations
6,580 Views
18 Pages

2 March 2018

Microgrippers are typical microelectromechanical systems (MEMS) that are widely used for micromanipulation and microassembly in both biological and micromanufacturing fields. This paper presents the design, modelling, fabrication and experimental tes...

  • Article
  • Open Access
11 Citations
5,533 Views
18 Pages

2 March 2018

Four-dimensional (4D) biofabrication techniques aim to dynamically produce and control three-dimensional (3D) biological structures that would transform their shapes or functionalities with time, when a stimulus is imposed or cell post-printing self-...

  • Article
  • Open Access
12 Citations
6,337 Views
8 Pages

An Adaptable Interface Conditioning Circuit Based on Triboelectric Nanogenerators for Self-Powered Sensors

  • Yongshan Hu,
  • Qiuqin Yue,
  • Shan Lu,
  • Dongchen Yang,
  • Shuxin Shi,
  • Xiaokun Zhang and
  • Hua Yu

1 March 2018

In order to solve the limited life problem of typical battery power supply, a self-powered method that is based on the environmental energy harvesting has emerged as an amazing power supply approach. The Tribo-electric-Nano-generator (TENG) has been...

  • Feature Paper
  • Review
  • Open Access
87 Citations
14,436 Views
18 Pages

Liquid Biopsy in Lung Cancer: Clinical Applications of Circulating Biomarkers (CTCs and ctDNA)

  • Minji Lim,
  • Chi-Ju Kim,
  • Vijaya Sunkara,
  • Mi-Hyun Kim and
  • Yoon-Kyoung Cho

28 February 2018

Lung cancer is by far the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Recent advances in the understanding of the biology of tumors and in highly sensitive detection technolog...

  • Article
  • Open Access
7 Citations
5,555 Views
14 Pages

Fabrication of 3D Capillary Vessel Models with Circulatory Connection Ports

  • Mahmoud Gallab,
  • Kyohei Tomita,
  • Seiji Omata and
  • Fumihito Arai

28 February 2018

Bionic microscopic vessel models can contribute to the development of vascular treatment skills and techniques for clinical training. Most microscopic vessel models are limited to two dimensions, but three-dimensional (3D) models are important for su...

  • Article
  • Open Access
35 Citations
5,617 Views
24 Pages

28 February 2018

Induced-charge electroosmosis has attracted lots of attention from the microfluidic community over the past decade. Most previous researches on this subject focused on induced-charge electroosmosis (ICEO) vortex streaming actuated on ideally polariza...

  • Article
  • Open Access
1 Citations
3,859 Views
11 Pages

Experimental Research on Fluid Coupling Flexible Actuator

  • Xiangli Zeng,
  • Yue Wu,
  • Qianjin Tu,
  • Jingshi Dong,
  • Zhigang Yang and
  • Xinbo Li

28 February 2018

In the field of micromechanics, piezoelectric actuator has attracted great attention for its high-frequency response, high displacement resolution, and high output force. However, its prospect of practical application has been largely limited by the...

  • Article
  • Open Access
33 Citations
10,855 Views
26 Pages

Design, Fabrication, and Implementation of an Array-Type MEMS Piezoresistive Intelligent Pressure Sensor System

  • Jiahong Zhang,
  • Jianxiang Chen,
  • Min Li,
  • Yixian Ge,
  • Tingting Wang,
  • Peng Shan and
  • Xiaoli Mao

28 February 2018

To meet the radiosonde requirement of high sensitivity and linearity, this study designs and implements a monolithically integrated array-type piezoresistive intelligent pressure sensor system which is made up of two groups of four pressure sensors w...

  • Article
  • Open Access
20 Citations
5,613 Views
13 Pages

27 February 2018

Ultrasonic transducer based on rare-earth giant magnetostrictive materials was designed in accordance with the technical requirements of ultrasonic surface strengthening. The whole structure of the transducer was designed. Modal analysis is made to g...

  • Article
  • Open Access
8 Citations
4,587 Views
12 Pages

Theoretical Studies of the Spin-Dependent Electronic Transport Properties in Ethynyl-Terminated Ferrocene Molecular Junctions

  • Shundong Yuan,
  • Shiyan Wang,
  • Zhaoyang Kong,
  • Zhijie Xu,
  • Long Yang,
  • Diansheng Wang,
  • Qidan Ling and
  • Yudou Wang

26 February 2018

The spin-dependent electron transport in the ferrocene-based molecular junctions, in which the molecules are 1,3-substituted and 1,3′-substituted ethynyl ferrocenes, respectively, is studied by the theoretical simulation with nonequilibrium Green’s f...

  • Article
  • Open Access
35 Citations
7,564 Views
12 Pages

Fabrication of a Micro-Lens Array Mold by Micro Ball End-Milling and Its Hot Embossing

  • Peng Gao,
  • Zhiqiang Liang,
  • Xibin Wang,
  • Tianfeng Zhou,
  • Jiaqing Xie,
  • Shidi Li and
  • Wenhua Shen

26 February 2018

Hot embossing is an efficient technique for manufacturing high-quality micro-lens arrays. The machining quality is significant for hot embossing the micro-lens array mold. This study investigates the effects of micro ball end-milling on the machining...

  • Review
  • Open Access
26 Citations
7,410 Views
16 Pages

Optofluidic Tunable Lenses for In-Plane Light Manipulation

  • Qingming Chen,
  • Tenghao Li,
  • Zhaohui Li,
  • Jinlin Long and
  • Xuming Zhang

26 February 2018

Optofluidics incorporates optics and microfluidics together to construct novel devices for microsystems, providing flexible reconfigurability and high compatibility. Among many novel devices, a prominent one is the in-plane optofluidic lens. It manip...

  • Article
  • Open Access
3 Citations
9,226 Views
12 Pages

Electrowetting Using a Microfluidic Kelvin Water Dropper

  • Elias Yazdanshenas,
  • Qiang Tang and
  • Xiaoyu Zhang

25 February 2018

The Kelvin water dropper is an electrostatic generator that can generate high voltage electricity through water dripping. A conventional Kelvin water dropper converts the gravitational potential energy of water into electricity. Due to its low curren...

  • Article
  • Open Access
21 Citations
6,776 Views
13 Pages

25 February 2018

A radio-frequency micro-electro-mechanical system (RF MEMS) wafer-level packaging (WLP) method using pre-patterned benzo-cyclo-butene (BCB) polymers with a high-resistivity silicon cap is proposed to achieve high bonding quality and excellent RF perf...

  • Article
  • Open Access
82 Citations
7,049 Views
19 Pages

25 February 2018

Microfluidic devices have been widely used for biological and cellular studies. Microbioreactors for three-dimensional (3D) multicellular spheroid culture are now considered as the next generation in in vitro diagnostic tools. The feasibility of usin...

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Micromachines - ISSN 2072-666X