Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma
Abstract
:1. Introduction
2. Bromodomain-Containing Protein BAF180 Function
3. PBRM1 Mutations in Clear Cell Renal Cell Carcinoma
4. Prognostic Value of PBRM1 Mutations in Localized and Advanced Disease
4.1. Localized Disease
4.2. Advanced Disease
5. Predictive Value of PBRM1 Mutations
5.1. Targeted Therapy
5.2. Immunotherapy
6. Future Perspectives and Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author [Ref.] | Year | Country | Gender M(%)/F(%) | Age (y) | N | BAP1 MT(%) | PBRM1 MT(%) | Tech | Survival Efficacy Parameters | |
---|---|---|---|---|---|---|---|---|---|---|
RFS (HR/ p) | OS (HR/ p) | |||||||||
Kapur [40] | 2013 | USA | 80(55)/65(45) | 62 | 145 | 21(14) | 78(54) | NGS | NA | BAP1 MT: 4.6; PBRM1 MT: 10.6 (2.7/0.044) |
Gossage [41] | 2014 | UK | 83(63)/49(37) | 62 | 132 | 14(11) | 42(33) | NGS | BAP1 MT: 1.2 a; PBRM1 MT: 4.9 a (n.sp./0.059) | n.sp. (n.sp./NS) |
Disease Type | Author [Ref.] | Year | Country | Gender M(%)/F(%) | Age (y) | N | PBRM1 -/Low (%) | Tech | Ab (Dilution) | PBRM1 Cut-off | Survival Efficacy Parameters | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
RFS/PFS (HR/p) | OS/CSS (HR/p) | |||||||||||
Loc | da Costa [43] | 2013 | Brazil | 66(59)/46(41) | 56 | 112 | 34(30) | IHC | PB1 Ab b (1:25) | Presence | PBRM1 -: 66.7% vs. PBRM1 +: 87.3% d (n.sp./0.048) | PBRM1 -: 70.6 vs. PBRM1 +: 89.7% f (n.sp./0.017) |
Hakimi [46] | 2013 | USA | 408(67)/200(33) | 61 | 609 | 198(33) | NGS | - | - | NA | n.sp. (n.sp./NS) | |
Pawlowski [42] | 2013 | Switzerland | NA | NA | 279 | 175(64) a. | IHC | PB1Ab c (1:25) | >5% | NA | PBRM1 -: 80 vs. PBRM1 +: not reach (n.sp./0.025) | |
Nam [45] | 2015 | Korea | 485(74)/172(26) | NA | 657 | NA | IHC | PB1 Ab c (1:100) | >50% | PBRM1 LE: 109.5 vs. PBRM1 HE: 156.2 (n.sp./<0.001) | PBRM1 LE: 145.5 vs. PBRM1 HE: 171.7 (n.sp./<0.001) | |
Joseph [36] | 2016 | USA | 823(62)/435(33) | 64 | 1330 | 674(51) | IHC | PB1 Ab c | Presence | PBRM1 -: higher mtx. risk (1.46/0.001) | n.sp. (n.sp/NS) | |
Kim [52] | 2017 | Korea | 244(70)/107(30) | 54 | 351 | 208(59) | IHC | PB1 Ab | Score > 2 | n.sp. (0.81/0.64) | n.sp. (1.86/0.1) | |
Loc and Mtx | Jiang [47] | 2017 | USA | 118(74)/42(26) | 60 | 160 | 49(31) | IHC | PB1 Abc (1:50) | >5% | n.sp. (0.79/0.21) | n.sp. (0.42/2.45e–05) |
Carlo [49] | 2017 | USA | 77(73)/28(27) | 57 | 105 | 53(51) | NGS | - | - | PBRM1 MT: 12.0 vs. PBRM1 WT: 6.9 e (n.sp./0.01) | PBRM1 MT: not reach vs. PBRM1 WT: 36.3 (n.sp./0.12) | |
Mtx | Tennenbaum [50] | 2017 | USA | 116(69)/51(31) | 60 | 167 | 64(38) | NGS | - | - | NA | n.sp. (0.87/0.49) |
Kim [48] | 2015 | Korea | 44(83)/9(17) | 62 | 53 | 28(52) | IHC | PB1 Ab c (1:100) | Score >2.5 | NA | PBRM1 LE: 46 vs. PBRM1 HE: 24 (n.sp./0.022) | |
Voss [51] | 2018 | USA | 279(74)/98(26) | 61 | 357 | 160(45) | NGS | - | - | PBRM1 MT: 11.1 vs. PBRM1 WT: 8.2 (0.67/0.004) | PBRM1 MT: 35.5 vs. PBRM1 WT: 23.8 (0.63/0.002) |
Author [Ref.] | Year | Country | Gender M(%)/F(%) | Age (y) | N | BAP1 MT (%) | PBRM1 MT (%) | Tech | Ab(Dilution) | PBRM1 Cut-off | Everolimus PFS | Sunitinib PFS |
---|---|---|---|---|---|---|---|---|---|---|---|---|
PBRM1 MT or LE vs. PBRM1 WT or HE (HR/ p) | PBRM1 MT or LE vs. PBRM1 WT or HE (HR/ p) | |||||||||||
Hsieh [56] | 2016 | USA | 168 (76)/52(24) | 62 | 220 | 42(19) | 101(46) | NGS | - | - | 12.8 vs. 5.5 (0.53/ 0.004) | 11.0 vs. 8.3 (0.79/ 0.4) |
Kim [48] | 2015 | Korea | 44(83)/9(17) | 62 | 53 | NA | 25(47) | IHC | PB1 Ab a (1:100) | 2.5 | 3.0 vs. 1.9 (NA/ 0.1) | 7.3 vs. 9 (NA/ 0.8) |
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Carril-Ajuria, L.; Santos, M.; Roldán-Romero, J.M.; Rodriguez-Antona, C.; de Velasco, G. Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma. Cancers 2020, 12, 16. https://doi.org/10.3390/cancers12010016
Carril-Ajuria L, Santos M, Roldán-Romero JM, Rodriguez-Antona C, de Velasco G. Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma. Cancers. 2020; 12(1):16. https://doi.org/10.3390/cancers12010016
Chicago/Turabian StyleCarril-Ajuria, Lucía, María Santos, Juan María Roldán-Romero, Cristina Rodriguez-Antona, and Guillermo de Velasco. 2020. "Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma" Cancers 12, no. 1: 16. https://doi.org/10.3390/cancers12010016