MicroRNA in Papillary Thyroid Carcinoma: A Systematic Review from 2018 to June 2020
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Up- and Downregulated microRNAs in Papillary Thyroid Cancer
3.2. One Gene Can Be Targeted by Several microRNAs
3.3. One MicroRNA Can Target Several mRNAs/Genes
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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miRNA | Sample Sources | Up/Down-Regulated | Targeted Gene | miRNA Effect on PTC Cells | Sponging/Sequestering | Potential Utility | References |
---|---|---|---|---|---|---|---|
miR-520a-3p | tissue | Down | JAK1 | prevented cell proliferation, migration, invasion, promoted apoptosis | TT | Bi. CL et al. [12] | |
miR-139-5p | tissue | Down | LMO4 | suppressed cell proliferation, migration, and tumor growth | circBACH2 | Pr, TT | Cai. X et al. [13] |
miR-128 | tissue | Down | SPHK1 | elevated apoptosis increased G0/G1 arrest, reduced Cyclin D1/ CDK4 expressions | - | TT | Cao. XZ et al. [14] |
miR-2861 | tissue | Up | DGCR5 | promoted cell proliferation and invasion | lncRNA DGCR5 | Pg | Chen. F et al. [15] |
miR-101 | tissue | Down | CXCL12 | repressed cell proliferation, migration, and invasion. Enhanced apoptosis | - | Pg, TT | Chen. F et al. [16] |
miR-135b-5p | tissue | Up | CCNG2 | modulated tumor cells proliferation, apoptosis, migration | lncRNA GAS8-AS1 | TT | Chen. N et al. [17] |
miR-202-3p | tissue | Down | WNT | suppressed the expression of β-catenin, cell migration, and invasion | - | TT | Chen. J et al. [18] |
miR-1271 | tissue | Up | IRS1 | suppressed migration, invasion, and proliferation of PTC cells | - | TT | Chen. Y et al. [19] |
miR-153-3p | tissue | Down | ZNRF2 | regulated cell proliferation, migration, and invasion | lncRNA TTN-AS1 | TT | Cui. Z et al. [20] |
miR-548c-3p | tissue | Down | HIF1α | reducted N-cadherin and vimentin expression | - | Pg, TT | Du. Y et al. [21] |
miR-150 | tissue | Down | MUC4 | suppressed PTC cell proliferation and metastasis | - | Dg, TT | Fa. Z et al. [22] |
Ex-miR-103 | blood | Up | GPER1 | influenced the differentiation of CD4 + T cell into Treg cells | - | TT | Fang. T et al. [23] |
miR-625-3p | tissue | Up | AEG-1 | promoted the proliferation, migration, and invasion of thyroid cancer cells | - | TT | Fang. L et al. [24] |
miR-141-3p | tissue | Down | YY-1 | inhibited cell growth, induced apoptosis, and suppressed invasion | - | Pg, TT | Fang. M et al. [25] |
miR-613 | tissue | Down | SphK2 | inhibited cell proliferation, migration, and invasion | lncRNA LINC00460 | TT | Feng. L et al. [26] |
miR-93-3p-660 | tissue | Up | FOXO1 | inhibited glycolysis that attenuated glucose uptake and lactate production | lncRNA ASMTL-AS1 | TT | Feng. Z et al. [27] |
miR-1266 | tissue | Down | FGFR2 | inhibited PTC cell proliferation, migration, and invasion | - | Dg, TT | Fu. YT et al. [28] |
miR-129 | tissue | Up | MAL2 | suppressed growth and invasion of PTC cells | - | Pv, TT | Gao. X et al. [29] |
miR-791 | tissue | Down | - | inhibited proliferation of PTC cells via blocking the G1 phase | - | Pg, TT | Gao. XB et al. [30] |
miR-429 | tissue | Down | ZEB1 | inhibited cell proliferation, migration, and invasion | lncRNA SNHG22 | Dg, TT | Gao. H et al. [31] |
miR-30a | tissue | Down | E2F7 | inhibited the proliferation, migration, and invasion of PTC cells | - | TT | Guo. H et al. [32] |
miR-9-5p | tissue | Down | BRAF | suppressed the viability of PTC cells by inducing apoptosis | - | TT | Guo. F et al. [33] |
miR-215 | tissue | Down | ARFGEF1 | inhibited proliferation and metastasis | - | Pg | Han. J et al. [34] |
Ex-miR-199 | blood | Down | DLG1-AS1 | suppressed proliferation of PTC cells | - | Dg | He. T et al. [35] |
miR-1252 | tissue | Up | FSTL1 | inhibited viability, proliferation, and stimulated apoptosis in PTC cells. | hsa_circ_ 0011290 | TT | Hu. Z et al. [36] |
miR-486-5p | tissue | Down | KIAA1199 | inhibited cell growth of PTC | - | TT | Jiao. X et al. [37] |
miR-885-5p | tissue | Down | RAC1 | suppressed PTC cell proliferation | hsa_circ_ 0004458 | TT | Jin. X et al. [38] |
miR-15a | tissue | Down | RET/AKT | inhibited PTC cell proliferation and invasion and enhanced the apoptosis | - | TT | Jin. J et al. [39] |
miR-381-3p | tissue | Down | LRP6 | inhibited the proliferation and metastasis of PTC cells | - | TT | Kong. W et al. [40] |
miR-485-5p | tissue | Down | Raf1 | inhibited PTC cell proliferation, migration and invasion | LncRNA LINC00460 | TT | Li. G et al. [41] |
miR-320a | cell culture | Up | HMGB1 | inhibited cell proliferation, migration and invasion rates | lncRNA ANRIL | Pv, TT | Li. M et al. [42] |
miR-369-3p | cell culture | Down | TSPAN13 | suppressed cell proliferation, colony formation, and induced apoptosis in PTC | - | Dg, Pv, TT | Li. P et al. [43] |
miR-205 | tissue | Down | YAP1 | inhibited proliferation and invasion of thyroid cancer cells | - | TT | Li. D et al. [44] |
miR-204-3p | tissue | Down | CDC23 | suppressed PTC proliferation, migration and invasion | lncRNA LINC00514 | TT | Li. X et al. [45] |
miR-361-5p | tissue | Down | ROCK1 | Inhibited proliferation, migration, and invasion | - | TT | Li. R et al. [46] |
miR-4500 | cell culture | Down | PLXNC1 | inhibited cell viability, colony formation, and cell apoptosis | - | Pg, TT | Li. R et al. [47] |
miR-211-5p | tissue | Down | SPARC | suppressed proliferation, migration, and invasion of thyroid tumor cells | lncRNA MCM3AP-AS1 | TT | Liang. M et al. [48] |
miR-101 | tissue | Down | FN1 | promoted the RAI-resistance in PTC | lncRNA-NEAT1 | TT | Liu. C et al. [49] |
miR-214 | tissue | Down | PSMD10 | suppressed proliferation, and induced cell apoptosis and cell cycle arrest in PTC cells | - | TT | Liu. F et al. [50] |
miR-744 | tissue | Down | NOB1 | attenuated the proliferation and invasion of PTC cells | - | TT | Liu. H et al. [51] |
miR-96-5p | tissue | Up | CCDC67 | accelerated the proliferation and metastasis of PTC cells | - | Dg, TT | Liu. ZM et al. [52] |
miR-4728 | cell culture | Down | SOS1 | repressed the PTC cell proliferation through MAPK | - | Dg, TT | Liu. Z et al. [53] |
miR-431 | tissue | Down | Gli1 | inhibited cell migration and invasion of PTC | - | TT | Liu. Y et al. [54] |
miR-524-5p | tissue | Down | FOXE1, ITGA3 | suppressed PTC progression by regulating tumor cell proliferation, migration, and invasion | - | TT | Liu. H et al. [55] |
miR-331-3p | tissue | Down | SLC25A1 | inhibited PTC cells proliferation, migration and invasion | lncRNA-BRM | TT | Liu. S et al. [56] |
miR-335-5p | tissue | Down | ICAM1 | reduced the proliferation, migration, invasion of PTC | - | TT | Luo. L et al. [57] |
miR-146a | tissue | - | GABPA | suppressed proliferation, migration, and invading capabilities of PTC cells | TT | Long. M et al. [58] | |
miR-29a-3p | tissue | Down | OTUB2 | suppressed growth, proliferation, invasion in PTC cells. | - | Pg, TT | Ma. Y et al. [59] |
miR-199a-5p | tissue | Down | SNAI1 | reduced migration and invasion of PTC cells | - | TT | Ma. S et al. [60] |
miR-363-3p | tissue | Down | ITGA6 | suppressed anoikis resistance in PTC cells | - | TT | Pan. Y et al. [61] |
miR-1231, miR-1304 | tissue | Down | - | inhibited proliferation and invasion of PTC cells | circ_ 0025033 | TT | Pan. Y et al. [62] |
miR-146b-5p | tissue | Up | DNMT3A | accelerated extra-glandular invasion and metastasis of PTC cells | lncRNA-MALAT1 | Dg, TT | Peng. Y et al. [63] |
miR-448 | tissue | Down | KDM5B | inhibited PTC cell progression and tumor growth via TGIF1 | - | TT | Pu. Y et al. [64] |
miR-199b-5p | tissue | Down | STON2 | inhibited PTC cell growth and metastasis | - | TT | Ren. L et al. [65] |
miR-26a-5p | tissue | Down | Wnt5a | inhibited proliferation, colony formation, invasion, and migration of PTC cells. | - | TT | Shi. D et al. [66] |
miR-564 | tissue | Down | AEG-1 | inhibited cell proliferation, migration, and invasion and induced cell apoptosis | - | TT | Song. Z et al. [67] |
miR-214-3p | tissue | Down | PSMD10 | impaired PTC cell proliferation and metastasis | lncRNA-SNHG3 | TT | Sui. G et al. [68] |
miR-144 | tissue | Down | WWTR1 | inhibited of PTC cell proliferation | - | Pg, TT | Sun. W et al. [69] |
miR-106b-5p | tissue | Down | ATAD2 | induced apoptosis and suppressed invasion of PTC cells | lncRNA-NEAT1_2 | TT | Sun. W et al. [70] |
miR-124-3p | cell culture | Down | MAP2K4 | inhibited the proliferation, induced apoptosis and cell cycle arrest in PTC cells | - | TT | Sun. Y et al. [71] |
miR-577 | tissue | Down | Sphk2 | inhibited PTC cell proliferation, migration, and invasion | lncRNA-LINC00520 | Dg, TT | Sun. Y et al. [72] |
miR-486 | tissue | Down | TENM1 | inhibited proliferation, invasion, and migration of PTC cell | - | TT | Sun. YH et al. [73] |
miR-497 | tissue | Down | BDNF | suppressed PTC cell proliferation, migration, and invasion | lncRNA-LINC00152 | TT | Sun. Z et al. [74] |
miR-22 | tissue | Up | - | promoted PTC cell metastasis and BRAFV600E mutation | - | Dg, Pg | Wang. D et al. [75] |
miR-599 | tissue | Down | Hey2 | diminished PTC cell proliferation, migration, invasion, while stimulating apoptosis | - | Pr, TT | Wang. DP et al. [76] |
miR-3619-5p | cell culture | Down | FOXM1 | regulated proliferation and apoptosis in PTC | lncRNA-Linc01410 | TT | Wang. G et al. [77] |
miR-675 | tissue | Down | MAPK1 | suppressed PTC cell proliferation, migration, and invasion | lncRNA-RMRP | TT | Wang. J et al. [78] |
miR-1258 | cell culture | Down | TMPRSS4 | inhibited cell viability, migration, and invasion | - | Dg, TT | Wang. L et al. [79] |
miR-451a | tissue | Down | ZEB1 | suppressed proliferation, mobility, and invasion of PTC cell | - | TT | Wang. Q et al. [80] |
miR-622 | tissue | Down | VEGFA | inhibited PTC cell proliferation, migration, and invasion | - | TT | Wang. R et al. [81] |
miR-212 | tissue | Down | MIAT | inhibited PTC cell proliferation, migration, and invasion. | (possible) lncRNA-MIAT | TT | Wang. R et al. [82] |
miR-718 | tissue | Down | PDPK1 | inhibited PTC cell growth, reduced cell invasion, repressed glucose metabolism | - | Dg, TT | Wang. X et al. [83] |
miR-31 | tissue | Down | SOX11 | repressed PTC cell proliferation, invasion, and migration | - | TT | Wang. Y et al. [84] |
miR-384 | tissue | Down | PRKACB | suppressed PTC cell proliferation and migration | - | TT | Wang. Y et al. [85] |
miR-873 | tissue | Down | CXCL16 | inhibited proliferation, migration, and invasion of the PTC cells | - | TT | Wang. Z et al. [86] |
miR-143-3p | tissue | Down | MSI2 | induced apoptosis, suppresses invasion and migration of PTC | - | TT | Wang. ZL et al. [87] |
miR-1261 | tissue | Down | C8orf4 | inhibited PTC cell proliferation, migration, and invasion | circZFR | TT | Wei. H et al. [88] |
miR-200a-3p | tissue | Down | YAP1 | inhibited PTC cell proliferation and promoted apoptosis | lncRNA-SNHG15 | TT | Wu. DM et al. [89] |
miR-329 | tissue | Down | WNT1 | decreased PTC cell proliferation, colony formation, suppressed growth | - | TT | Wu. L et al. [90] |
miR-203 | tissue | Down | Bcl-2 | inhibited cell proliferation, induced apoptosis, and suppressed the motility of PTC cells | - | TT | Wu. X et al. [91] |
miR-26a | tissue | Down | ROCK1 | repressed PTC cell viability, invasion, and metastasis | - | Dg, TT | Wu. YC et al. [92] |
miR-222 | tissue | Up | - | correlated with capsular invasion, vascular invasion, tumor size and metastasis | - | Pg | Xiang. D et al. [93] |
miR-150-5p | cell culture | Up | BRAF(V600E) | promoted PTC cell proliferation, suppressed apoptosis | - | TT | Yan. R et al. [94] |
miR-423-5p | cell culture | Down | SOX12 | suppressed PTC cell proliferation and invasion | lncRNA-NR2F1-AS1 | TT | Yang. C et al. [95] |
miR-182 | tissue | Up | CHL1 * | correlated with extrathyroidal invasion, cervical lymph node metastasis, and TNM | - | Pg | Yao. XG et al. [96] |
miR-1179 | tissue | - | HMGB1 | - | circFOXM1 | TT | Ye. M et al. [97] |
miR-1270 | cell culture | Up | SCAI | promoted PTC cell proliferation, migration | - | TT | Yi. T et al. [98] |
miR-761 | tissue | Down | TRIM29 | inhibited cell proliferation, and cell cycle progression in PTC | lncRNA- HOXA11-AS | TT | Yin. X et al. [99] |
miR-23a- | tissue | Down | CCNG1 | decreased proliferation, induced cell cycle arrest, and promoted PTC cell apoptosis | - | Dg, TT | Yin. JJ et al. [100] |
miR-203 | tissue | Down | AKT3 | suppressed cell migration and invasion in the PTC cells and promoted cell apoptosis | - | TT | You. A et al. [101] |
miR-3619-3p | tissue | Up | Wnt | promoted PTC cell migration and invasion | - | TT | Yu. S et al. [102] |
miR-637 | tissue | Down | Akt1 | inhibit inhibited PTC cell proliferation, invasion, and migration | lncRNA HOTTIP | Dg, TT | Yuan. Q et al. [103] |
miR-21 | tissue | Up | VHL | promoted PTC cell proliferation and invasion | - | TT | Zang. C et al. [104] |
miR-224-5p | tissue | Up | EGR2 | promoted PTC cell migration, invasion | - | Dg, TT | Zang. CS et al. [105] |
miR-509 | tissue | Down | PAX9 | inhibited cell proliferation and invasion in papillary thyroid carcinoma | - | TT | Zhang. S et al. [106] |
miR-766 | tissue | Down | IRS2 | inhibited proliferation of PTC cells | - | TT | Zhao. J et al. [107] |
miR-96-3p | tissue | Up | SDHB | increased the invasion and migration of PTC cells | TT | Zhao. X et al. [108] | |
miR-138-5p | tissue | Down | LRRK2 | inhibited PTC cell proliferation, apoptosis | lncRNA RP11-476D10.1 | TT | Zhao. Y et al. [109] |
miR-409-3p | tissue | Down | CCND2 | negatively regulated PTC cell proliferation and cell cycle progression | - | Pr, TT | Zhao. Z et al. [110] |
miR-200b/c | tissue | Down | Rap1b | inhibited PTC cell invasion, migration and growth | - | TT | Zhou. B et al. [111] |
miR-188-5p | tissue | Down | FGF-5 * | suppressed PTC cells growth | - | TT | Zhou. P et al. [112] |
miR-506 | tissue | Down | IL17RD | inhibited the proliferation, invasion, and migration capacities of PTC cells | - | Pg, TT | Zhu. J et al. [113] |
miR-146 | tissue | Up * | KIT | promoted PTC cell proliferation and invasion * | lncRNA CTC | TT | Liao. B et al. [114] |
miR-1178 | tissue | Up | TLR4 | promoted cell proliferation and suppressed cell apoptosis | circ_FNDC3B | TT | Wu. G et al. [115] |
miR-106a | tissue | Up | PTEN/ SFR4 | enhanced PTC cell proliferative, migratory and invasive abilities | lncRNA-HULC | TT | Yang. Z et al. [116] |
miR-335 | tissue | Down | SOX2 | suppressed the proliferation, migration, and invasion of PTC cells | lncRNA-LINC01510 | TT | Li. Q et al. [117] |
miR-199a-5p | tissue | Down | SLC1A5 | attenuated proliferation, induced apoptosis, and arrested cells in the G0/G1 phase | ABHD11-AS1 | Dg, TT | Zhuang. X et al. [118] |
miR-145-5p | tissue | Down | AKT3 | inhibited proliferation, migration and invasion | lncRNA-n384546 | Dg, TT | Feng. J et al. [119] |
miR-211 | tissue | Up | RECK | promoted tumor growth and increased tumor volume in PTC cells | - | Dg, Pg | Wei. ZL et al. [120] |
miR-206 | tissue | Down | MAP4K3 | enhanced Euthyrox sensitivity in Euthyrox-resistant PTC cells | - | TT | Liu. F et al. [121] |
miR-21-5p | cell culture | Up | TGFBI, COL4A1 | secreted by hypoxic PTC cells is a potent pro-angiogenic factor | - | Dg, TT | Wu. F et al. [122] |
Ex-miR-423-5p | blood | Up | - | promoted PTC cell migration and invasion | - | Dg, TT | Ye. W et al. [123] |
miR-422a | tissue | Down | SP1 | suppressed PTC cells proliferation and metastasis | lncRNA-LINC00313 | TT | Yan. D et al. [124] |
miR-1301-3p | tissue | Down | STAT3 | inhibited PTC cell proliferation, cell apoptosis -accelerated | lncRNA-ABDH11-AS1 | TT | Wen. J et al. [125] |
miR-let-7a | tissue | Down | c-Myc | suppressed PTC cell proliferation, migration, and invasion | - | TT | Huang. J et al. [126] |
miR-let-7e | tissue | Down | HMGB1 | inhibited of PTC cell growth and metastasis | - | TT | Ding. C et al. [127] |
miR-146b-5p | tissue | Up | CCDC6 | promoted proliferation, migration, invasion, and cell cycle progression of PTC cells | - | Dg, TT | Jia. M et al. [128] |
miR-145 | tissue | Down | ZEB2 | inhibited the migration, invasion, and tumorigenesis of PTC cells | circ_NUP214 | TT | Li. X et al. [129] |
miR-520c-3p | tissue | Down | S100A4 | inhibited PTC cells proliferation | lncRNA-HOXA-AS2 | TT | Xia. F et al. [130] |
miR-15a-5p | tissue | Down | - | inhibited PTC cells growth | lncRNA-HOXA-AS2 | TT | Jiang. L et al. [131] |
miR-146b-3p | tissue | Up | NF2 | increased PTC cell migration and invasion | - | TT | Yu. C et al. [132] |
miR-22a-3p | tissue | Up | CBL | promoted PTC cell proliferation and invasion | circ_ITCH | TT | Wang. M et al. [133] |
miR-21 | cell culture | - | PTEN | matrine- induced apoptosis and G1 cell cycle arrest | - | TT | Zhao. L et al. [134] |
miR-204 | tissue | Down | BRD4 | inhibited of PTC cell proliferation | lncRNA-UCA1 | TT | Li. D et al. [135] |
miR-4429 | tissue | Down | Bcl-2 | suppressed PTC cell proliferation, promoted apoptosis, and induced cell cycle arrest in G2/M phase | lncRNA-LINC00313 | TT | Wu. JW et al. [136] |
miR-222 | tissue | Up * | PPP2R2A | promoted PTC cell migration and invasion | - | Dg, TT | Huang. Y et al. [137] |
miR-21-5p | tissue | Down | Bcl-2 | inhibited TPC cell proliferation and invasion | lncRNA-BISPR | Dg, TT | Zhang. H et al. [138] |
miR-30a | tissue | Down | IGF1R | inhibited PTC cell proliferation, cycle progression, invasion, migration | lncRNA-PVT1 | TT | Feng. K et al. [139] |
miR-129-5p | tissue | Down | KLK7 | inhibited proliferation, cell survival, invasion, and migration | lncRNA-NEAT1 | TT | Zhang. H et al. [140] |
Ex-miR-146b-5p, Ex-miR-222-5p | blood | Down | - | enhanced the migration and invasion activity of PTC cells | - | Pg | Jiang. K et al. [141] |
miR-539 | tissue | Down | SLPI | inhibited PTC cell EMT and tumor growth | - | TT | Xu. CB et al. [142] |
miR-24-3p | tissue | Up | p27kip1 | regulated PTC cell proliferation, apoptosis migration and invasion | ncRNA-MIR22HG | TT | Chen. ZB et al. [143] |
miR-26a | cell culture | Down | ARPP19 | promoted proliferation of PTC cells | - | TT | Gong. Y et al. [144] |
Ex-miR-98-5p | blood | Down | HMGA2 | promoted PTC cell growth, inhibited apoptosis | - | Dg, Pg | Qiu. K et al. [145] |
miR-296-5p | tissue | Down | PLK1 | suppressed cell proliferation, inhibited cell clone formation, arrested the cell cycle in G2/M phase, and induced apoptosis | - | TT | Zhou. SL et al. [146] |
miR-451a | cell culture | Down * | PSMB8 | inhibited proliferation, EMT and induced apoptosis of PTC cells | - | TT | Fan. X et al. [147] |
miR-630 | tissue | Down | JAK2/ STAT3 | suppressed migration and invasion of PTC cells | - | TT | Pan. XM et al. [148] |
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Hitu, L.; Gabora, K.; Bonci, E.-A.; Piciu, A.; Hitu, A.-C.; Ștefan, P.-A.; Piciu, D. MicroRNA in Papillary Thyroid Carcinoma: A Systematic Review from 2018 to June 2020. Cancers 2020, 12, 3118. https://doi.org/10.3390/cancers12113118
Hitu L, Gabora K, Bonci E-A, Piciu A, Hitu A-C, Ștefan P-A, Piciu D. MicroRNA in Papillary Thyroid Carcinoma: A Systematic Review from 2018 to June 2020. Cancers. 2020; 12(11):3118. https://doi.org/10.3390/cancers12113118
Chicago/Turabian StyleHitu, Liviu, Katalin Gabora, Eduard-Alexandru Bonci, Andra Piciu, Adriana-Cezara Hitu, Paul-Andrei Ștefan, and Doina Piciu. 2020. "MicroRNA in Papillary Thyroid Carcinoma: A Systematic Review from 2018 to June 2020" Cancers 12, no. 11: 3118. https://doi.org/10.3390/cancers12113118